Results 31 to 40 of about 1,073,186 (289)

Orthopoxvirus IL-18 Binding Proteins: Affinities and Antagonist Activities

Virology, 2001
The affinities of purified recombinant human IL-18 binding protein (BP) and ectromelia and cowpox virus homologs for human and murine IL-18 were compared by plasmon resonance. The dissociation constants of human IL-18BP were similar for murine and human IL-18. By contrast, the dissociation constants of the viral proteins for murine IL-18 were 12- to 50-
Calderara, Silvio, Xiang, Yan, Moss, Bernard   +2 more
openaire   +2 more sources

Predicted IL-18/IL-18R Binding Improvement Through Protein Interface Modification with Computer-Aided Design. [PDF]

Biomolecules
Cytokine-mediated immunotherapy has rapidly emerged as an effective alternative approach for cancer treatment by modulating the anti-tumor response.
Prompat N, Peeyatu C, Saetang J, Roongsawang N, Sangkhathat S, Tipmanee V.   +5 more
europepmc   +2 more sources

Autoinflammatory periodic fever, immunodeficiency, and thrombocytopenia (PFIT) caused by mutation in actinregulatory gene WDR1 [PDF]

, 2017
The importance of actin dynamics in the activation of the inflammasome is becoming increasingly apparent. IL-1β, which is activated by the inflammasome, is known to be central to the pathogenesis of many monogenic autoinflammatory diseases.
Anderson, G, Blundell, MP, Brogan, PA, Eleftheriou, D, Gilmour, KC, Gomes, SM, Hong, Y, Jones, H, Klein, N, Kleta, R, Malinova, D, Medlar, A, Moulding, D, Nanthapisal, S, Nowak, K, Omoyinmi, E, Record, J, Standing, ASI, Stanescu, H, Thrasher, AJ   +19 more
core   +2 more sources

IL-18BP Improves Early Graft Function and Survival in Lewis–Brown Norway Rat Orthotopic Liver Transplantation Model

Biomolecules, 2022
Interleukin-18 (IL-18) can effectively activate natural killer (NK) cells and induce large concentrations of interferon-γ (IFN-γ). In healthy humans, IL-18 binding protein (IL-18BP) can inhibit the binding of IL-18 to IL-18R and counteract the biological
Qiang Meng, Weikang Wu, Wenjie Zhang, Juzheng Yuan, Long Yang, Xuan Zhang, Kaishan Tao   +6 more
doaj   +1 more source

Structural requirements of six naturally occurring isoforms of the IL-18 binding protein to inhibit IL-18 [PDF]

Proceedings of the National Academy of Sciences, 2000
A novel, constitutively expressed and secreted IL-18 binding protein (IL-18BP) neutralizes IL-18 and thereby suppresses the production of IFN-γ, resulting in reduced T-helper type 1 immune responses. In the present study, four human and two mouse isoforms, resulting from mRNA splicing and found in various cDNA libraries, were expressed, purified, and ...
S H, Kim, M, Eisenstein, L, Reznikov, G, Fantuzzi, D, Novick, M, Rubinstein, C A, Dinarello   +6 more
openaire   +2 more sources

Glucocorticoids for human skin: New aspects of the mechanism of action [PDF]

, 2005
Topical glucocorticoids have always been considered first-line drugs for inflammatory diseases of the skin and bronchial system. Applied systemically, glucocorticoids are used for severe inflammatory and immunological diseases and the inhibition of ...
Ahmed, M., Holtje, H. D., Kleuser, B., Korting, Hans Christian, Schäfer-Korting, Monika   +4 more
core   +1 more source

Surface cysteine to serine substitutions in IL-18 reduce aggregation and enhance activity [PDF]

PeerJ, 2022
Background Interleukin-18 (IL-18) is prone to form multimers resulting in inactive aggregates, making this cytokine unstable for clinical use. Therefore, mutations have been introduced into recombinant IL-18 to overcome this issue. Methods To prevent the
Jirakrit Saetang, Niran Roongsawang, Surasak Sangkhathat, Supayang Piyawan Voravuthikunchai, Natnaree Sangkaew, Napat Prompat, Teerapol Srichana, Varomyalin Tipmanee   +7 more
doaj   +2 more sources

Inflammatory responses in primary muscle cell cultures in Atlantic salmon (Salmo salar) [PDF]

, 2013
Peer reviewedPublisher ...
Martin, Samuel A.M., Pooley, Nicholas J., Secombes, Christopher J., Tacchi, Luca   +3 more
core   +2 more sources

IL–18 and IL–18 binding protein levels in patients with dengue virus infection

Asian Pacific Journal of Tropical Medicine, 2010
AbstractObjectiveTo determine the levels of IL-18 and IL-18 binding protein (BP) in patients with dengue virus infection.MethodsAcute and convalescent sera were collected from each patient. Control group was sera from blood donors. The levels of both IL-18 and IL-18BP were measured by ELISA assays.ResultsIt was shown that IL-18 and IL-18BP levels were ...
Chirathaworn, Chintana, Poovorawan, Yong, Vuthitanachot, Viboonsak   +2 more
openaire   +1 more source

Persistent systemic microbial translocation, inflammation, and intestinal damage during Clostridioides difficile infection [PDF]

, 2020
Background. Clostridioides difficile infection (CDI) might be complicated by the development of nosocomial bloodstream infection (n-BSI). Based on the hypothesis that alteration of the normal gut integrity is present during CDI, we evaluated markers of ...
Aversano, L., Battaglia, R., Bruno, G., Ciardi, M. R., Corazziari, E. S., de Angelis, M., Iera, J., Mascellino, M. T., Mastroianni, C. M., Miele, M. C., Morelli, S., Oliva, A., Venditti, M., Vullo, V.   +13 more
core   +1 more source