Results 91 to 100 of about 2,851 (168)
Advanced Science, Volume 12, Issue 18, May 15, 2025.This study identifies TREM2+ macrophages as key contributors to pathological bone formation in ankylosing spondylitis (AS). These macrophages mediate pathological new bone formation via the CREG1‐IGF2R‐PI3K‐AKT pathway and are regulated by IL‐33 through STAT6 phosphorylation.
Wenjun Hao +16 more
wiley +1 more source
HIV induces production of IL-18 from intestinal epithelial cells that increases intestinal permeability and microbial translocation. [PDF]
PLoS ONE, 2018 Interleukin-18 (IL-18) is a pleiotropic cytokine of the IL-1 family with multiple context dependent functions. We and others have shown that HIV infection is accompanied by increased circulating levels of IL-18 along with decreased levels of its ...
Ossama Allam +7 more
doaj +1 more source
Polymyositis And Dermatomyositis - Inflammation, Muscle Structure & Immunosuppressive Treatment [PDF]
, 2012 Polymyositis and dermatomyositis are chronic, inflammatory disorders characterized by muscle weakness, low muscle endurance and by inflammation in skeletal muscle tissues.
Loell, Ingela
core +1 more source
Molecular Genetics &Genomic Medicine, Volume 13, Issue 3, March 2025.We report a family with dentinogenesis imperfecta III. The proband and her mother showed rapid attrition and opalescent discoloration of teeth. The primary teeth showed “shell teeth” radiographically. We performed WES and Sanger sequencing on them and revealed a novel variant (c.38C>A: p.A13E) in the signal peptide region of the DSPP gene.
Yan Wang +3 more
wiley +1 more source
Role of inflammasomes and neuroinflammation in epilepsy
Immunological Reviews, Volume 329, Issue 1, January 2025.Summary Epilepsy is a brain disorder characterized by recurrent seizures, which are brief episodes of abnormal electrical activity in the brain and involuntary movement that can lead to physical injury and loss of consciousness. Seizures are canonically accompanied by increased inflammatory cytokine production that promotes neuroinflammation, brain ...
Ava Hollis, John R. Lukens
wiley +1 more source
Niveles de citocinas pro Th1 en orina de pacientes con lupus eritematoso sistémico [PDF]
, 2013 72 Páginas.Los estudios han sugerido que hay un imbalance en la producción de células T helper, (Th1 y Th2) que juega un papel importante en la patogénesis del LES. Además, se ha demostrado el predominio de genes de expresión de las citocinas Th1 y MCP-1
Rosero Revelo, Ricardo Javier +1 more
core
BioMed Research International, Volume 2025, Issue 1, 2025.Background: Immune‐related genes (IRGs) have been increasingly recognized as critical determinants in the multistage processes of cancer development and progression. However, the functional roles of IRGs in the incidence and progression of LGG remain to be studied.
Liubing Hou +7 more
wiley +1 more source
The nuclear receptor LXR modulates interleukin-18 levels through multiple mechanisms [PDF]
, 2016 IL-18 is a member of the IL-1 family involved in innate immunity and inflammation. Deregulated levels of IL-18 are involved in the pathogenesis of multiple disorders including inflammatory and metabolic diseases, yet relatively little is known regarding ...
A Druilhe +59 more
core +2 more sources
Embryo‐Derived Cathepsin B Promotes Implantation and Decidualization by Activating Pyroptosis
Advanced Science, Volume 11, Issue 43, November 20, 2024.The schematic view shows that embryo‐derived CTSB promotes implantation and decidualization by activating pyroptosis. Blastocyst‐derived CTSB activates NLRP3‐Caspase 1 to cleave GSDMD and cut pro‐IL‐1β/pro‐IL18 to form mature IL‐1β/IL‐18. The cleaved GSDMD‐N perforates the plasma membrane to release mature IL‐1β/IL‐18.
Meng‐Yuan Li +7 more
wiley +1 more source
mBioInterleukin-18 binding protein (IL-18BP), a natural regulator molecule of the pro-inflammatory cytokine interleukin-18 (IL-18), plays an important role in regulating the expression of the cellular immunity factor interferon-γ (IFN-γ).
Hong-zhe Zhao +5 more
doaj +1 more source