Results 101 to 110 of about 2,851 (168)
Advanced Science, Volume 11, Issue 43, November 20, 2024.Anti‐TGF‐β/PD‐L1 bispecific antibody YM101 enhances the anti‐tumor immune response but mediates the recruitment of immunosuppressive CCR5+ T cells through neutrophils. These cells highly express immunosuppressive molecules and undermine the immunotherapy efficacy.
Ming Yi +14 more
wiley +1 more source
Cell Proliferation, Volume 57, Issue 11, November 2024.Clustered network map displaying the frequency of hotspot words related to IL‐18. VOSviewer software was used to conduct co‐occurrence cluster analysis on keywords, with a minimum occurrence frequency of five times per keyword. A total of 3279 keywords were cleaned, meaningless words were removed, synonyms were merged, and 171 keywords were selected ...
Zhongzhi Wang
wiley +1 more source
Interleukin-18 as a Therapeutic Target in Western-diet Induced Cardiomyopathy [PDF]
, 2017 Background: Heart Failure (HF) is characterized by impaired cardiac function with symptoms of dyspnea, fatigue and exercise intolerance. Western diet (WD), a diet high in saturated fats and sugars, causes systemic increase in IL-18, a cytokine elevated ...
Narayan, Pratyush
core +1 more source
Interleukin-18 Binding Protein (IL-18BP): A Long Journey From Discovery to Clinical Application
Immune NetworkIL-18 binding protein (IL-18BP) was originally discovered in 1999 while attempting to identify an IL-18 receptor ligand binding chain (also known as IL-18Rα) by subjecting concentrated human urine to an IL-18 ligand affinity column. The IL-18 ligand chromatography purified molecule was analyzed by protein microsequencing. The result revealed a novel 40
Soohyun Kim +3 more
openaire +2 more sources
Effects of statins on T H [PDF]
, 2015 Background. Activation of the innate immune system by cholesterol accelerates atherosclerosis. High levels or modified forms of cholesterol stimulate release of the inflammatory cytokines IL-12 and IL-18 that synergistically stimulate T lymphocytes to ...
Berneis +29 more
core +2 more sources
Untersuchungen über die Regulation der Genexpression von Interleukin-18-Bindungsprotein und Interleukin-18 [PDF]
, 2009 Interleukin-18-Bindungsprotein (IL-18BP) ist ein erst kürzlich entdeckter Gegenspieler von Interleukin-18 (IL-18). Aufgrund der Eigenschaft von IL-18BP mit hoher Affinität an IL-18 zu binden, wird IL-18 neutralisiert und seine biologischen Wirkungen ...
Bosmann, Markus
core
Decoys and regulatory "receptors" of the IL-1/Toll Like Receptor superfamily
Frontiers in Immunology, 2013 Members of the IL-1 family play a key role in innate and adaptive immunity and in the pathogenesis of diverse diseases. Members of IL-1R like receptor (ILR) family include signalling molecules and negative regulators.
Cecilia eGarlanda +5 more
doaj +1 more source
Generation and engineering of potent single domain antibody-based bispecific IL-18 mimetics resistant to IL-18BP decoy receptor inhibition. [PDF]
MAbs, 2023 Lipinski B +16 more
europepmc +1 more source
Interleukin-18 Expression Increases in the Aorta and Plasma of Patients with Acute Aortic Dissection
Mediators of Inflammation, 2019 Background. Interleukin- (IL-) 18 is a proinflammatory cytokine related to cardiovascular diseases, including hypertension and atherosclerosis. This study is aimed at determining whether IL-18 is related to aortic dissection (AD) and identifying the ...
Haiying Hu +10 more
doaj +1 more source
Медицинская иммунология, 2014 . Cytokine-producing potential of peripheral blood cells was determined as a stimulation index with polyclonal activators (i.e., a cytokine production ratio of stimulated versus resting cells), as well as concentrations of cytokines were investigated in ...
A. V. Sosnina +7 more
doaj +1 more source