Results 71 to 80 of about 2,851 (168)

Cytokine Pathways Driving Diverse Tissue Pathologies in Rheumatoid Arthritis

Arthritis &Rheumatology, EarlyView.
Rheumatoid arthritis (RA) is a complex systemic disorder characterized primarily by articular inflammation and destruction with associated functional loss and reduced quality of life. RA is also associated with extra‐articular disease, such as that of the lung, with potentially devastating clinical consequences. The critical importance of comorbidities,
Aurelie Najm, Lyn D. Ferguson, Iain B. McInnes   +2 more
wiley   +1 more source

Paving the way for precision medicine v2.0 in intensive care by profiling necroinflammation in biofluids [PDF]

, 2019
Current clinical diagnosis is typically based on a combination of approaches including clinical examination of the patient, clinical experience, physiologic and/or genetic parameters, high-tech diagnostic medical imaging, and an extended list of ...
Hoste, Eric, Vanden Berghe, Tom
core   +2 more sources

Interleukin‐18 levels are associated with disease course in patients with Still's disease treated with IL‐1 inhibitors

Arthritis &Rheumatology, Accepted Article.
Objective To evaluate the prognostic utility of circulating Interleukin‐18 (IL‐18) levels in predicting disease activity, macrophage activation syndrome (MAS), and disease course in Still's disease (SD) patients receiving first‐line IL‐1 inhibitors (IL‐1i).
Matteo Trevisan, Manuela Pardeo, Ivan Caiello, Claudia Bracaglia, Arianna de Matteis, Valentina Matteo, Elena Loricchio, Fabrizio De Benedetti, Giusi Prencipe   +8 more
wiley   +1 more source

Vaccinia virus immune evasion: mechanisms, virulence and immunogenicity [PDF]

, 2013
Virus infection of mammalian cells is sensed by pattern recognition receptors and leads to an innate immune response that restricts virus replication and induces adaptive immunity.
Benfield, C T O, De Motes, C M, Ember, S W J, Ferguson, B J, Mazzon, M, Smith, G L, Sumner, R P   +6 more
core   +1 more source

IL-1 family cytokines and soluble receptors in systemic lupus erythematosus

Arthritis Research & Therapy, 2018
Background Dysregulated production of cytokines has a critical role in systemic lupus. The aim of this work is to identify, by a comprehensive analysis of IL-1 family cytokines and receptors in serum, correlation between cytokines/receptors’ levels and ...
Paola Italiani, Maria Laura Manca, Francesca Angelotti, Daniela Melillo, Federico Pratesi, Ilaria Puxeddu, Diana Boraschi, Paola Migliorini   +7 more
doaj   +1 more source

Serum Biomarkers of Disease Activity in Longitudinal Assessment of Patients with ANCA‐Associated Vasculitis

ACR Open Rheumatology, 2022
Objective Improved biomarkers of current disease activity and prediction of relapse are needed in antineutrophil cytoplasmic antibody–associated vasculitis (AAV).
Paul A. Monach, Roscoe L. Warner, Robert Lew, Gunnar Tómasson, Ulrich Specks, John H. Stone, Fernando C. Fervenza, Gary S. Hoffman, Cees G. M. Kallenberg, Carol A. Langford, Philip Seo, E. William St. Clair, Robert Spiera, Kent J. Johnson, Peter A. Merkel   +14 more
doaj   +1 more source

A Comprehensive Review of AIM2 in Cancer: Functional Roles, Molecular Pathways, and Clinical Relevance

Journal of Immunology Research, Volume 2026, Issue 1, 2026.
Inflammation has been recognized as a component of cancer progression, and inflammasome receptor components also regulate various biological processes, including cell proliferation, gene transcription, and tumorigenesis. Accumulating evidence indicates that the AIM2 inflammasome influences tumor progression via multiple concurrent mechanisms, one of ...
Nuo Wang, Shaoxian Wu, Zhang Fang, Lujun Chen, Xiao Zheng, Poorani Gurumallesh   +5 more
wiley   +1 more source

Bidirectional Regulation of NLRP3 Inflammasome and Mitochondrial Quality Control in Sepsis: Mechanisms and Therapeutic Implications

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Characterized by its capacity to induce organ failure, sepsis constitutes a life‐threatening pathological state with high incidence and mortality rates. Current treatments primarily focus on antimicrobial therapy and organ support, lacking direct interventions targeting the restoration of cellular or organelle function.
Xiangxin Liao, Yixun Wang, Zhaohui Zhang, Xingguang Qu, Gaosheng Zhou, Laurent L′homme   +5 more
wiley   +1 more source

Efficacy of Fowlpox Virus Vector Vaccine Expressing VP2 and Chicken Interleukin-18 in the Protection against Infectious Bursal Disease Virus

Vaccines, 2023
In mammals, the role of interleukin-18 (IL-18) in the immune response is to drive inflammatory and, normally therefore, anti-viral responses. IL-18 also shows promise as a vaccine adjuvant in mammals. Chicken IL-18 (chIL-18) has been cloned.
Ibrahim Eldaghayes, Lisa Rothwell, Michael Skinner, Abdunaser Dayhum, Pete Kaiser   +4 more
doaj   +1 more source

Milligram‐Scale Enzymatic Synthesis of Base‐Modified DNA through Primer Extension: Polymerase Synthesis and NMR Structures of DNA Containing Phenyl‐Substituted Nucleobases

ChemistryEurope, Volume 3, Issue 6, November 11, 2025.
Larger‐scale enzymatic synthesis of base‐modified DNA is developed using primer extension with KOD(exo‐) DNA polymerase allowing preparation of milligram amounts of the modified DNA sufficient for NMR structural analysis. Milligram (≈200 nmol) scale enzymatic synthesis of base‐modified DNA is developed based on primer extension using easily accessible ...
Veronika Raindlová, Klára Viktorinová, Michal Tichý, Lucie Bednárová, Pavel Srb, Miguel Riopedre‐Fernandez, Michal Hocek   +6 more
wiley   +1 more source