Results 81 to 90 of about 2,851 (168)

Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]

, 2020
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima, Al-Herz, Waleed, Bousfiha, Aziz, Casanova, Jean-Laurent, Chatila, Talal, Cunningham-Rundles, Charlotte, Etzioni, Amos, Franco, Jose Luis, Holland, Steven M, Jeddane, Leila, Klein, Christoph, Morio, Tomohiro, Ochs, Hans D, Oksenhendler, Eric, Picard, Capucine, Puck, Jennifer, Sullivan, Kathleen E, Tangye, Stuart G, Torgerson, Troy R   +18 more
core  

Elevated free interleukin-18 associated with severity and mortality in prospective cohort study of 206 hospitalised COVID-19 patients [PDF]

, 2022
Background Divergence between deterioration to life-threatening COVID-19 or clinical improvement occurs for most within the first 14 days of symptoms. Life-threatening COVID-19 shares clinical similarities with Macrophage Activation Syndrome, which can ...
Doffinger, Rainer, Kafizas, Andreas, Khan, Tauseef A., Nasser, Shuaib, Nasser, Syed M. T., Rana, Anas   +5 more
core   +1 more source

Anti‐Neuroinflammatory and Anti‐Inflammatory Effects of the NLRP3 Inhibitor NT‐0796 in Subjects with Parkinson's Disease

Movement Disorders, Volume 40, Issue 10, Page 2199-2208, October 2025.
Abstract Background Inhibition of Nod‐like receptor protein 3 (NLRP3) inflammasome within the central nervous system (CNS) is a promising therapeutic target for the treatment of Parkinson's disease (PD). Objectives This phase 1b open‐label study was conducted in elderly healthy volunteers (HV) and PD patients.
Nicholas Clarke, Peter Thornton, Valérie Reader, Nicola Lindsay, Zsofia Digby, Bianca Mullen, Michelle Gorman, Eric Jacobson, Grant Langdon, Hilary Johnstone, Alistair Wheeler, Alan P. Watt   +11 more
wiley   +1 more source

Macrophage activation syndrome triggered by coeliac disease: a unique case report [PDF]

, 2016
Background: Macrophage activation syndrome is described as a “clinical syndrome of hyperinflammation resulting in an uncontrolled and ineffective immune response” in the context of an autoinflammatory or rheumatic disease.
May, J, Palman, J, Pilkington, C
core   +1 more source

Natural Killer Cell‐Mediated Antitumor Immunity: Molecular Mechanisms and Clinical Applications

MedComm, Volume 6, Issue 9, September 2025.
NK cells eliminate tumors via cytotoxicity and cytokine secretion. Tumor microenvironment‐driven immunosuppression and metabolic reprogramming subvert NK cells’ cytotoxicity. The current clinical strategies to restore NK activity include ex vivo expansion for adoptive transfer, CAR‐NK engineering, TME‐remodeling agents, immune checkpoint blockade ...
Nanzhi Luo, Cong Chen, Wenjing Zhou, Jianqi Hao, Song He, Yu Liu, Yin Ku, Linhua Huang, Chuanfen Zhang, Yueli Shu, Xiaoqing Wu, Yaojia Zhou, Jian Zhang   +12 more
wiley   +1 more source

Upregulation of circulating microRNA-134 in adult-onset Still’s disease and its use as potential biomarker

Scientific Reports, 2017
Adult-onset Still’s disease (AOSD) is a multi-systemic inflammatory disorder of unknown etiology. To date, no single diagnostic test is available for AOSD. Herein, we investigated the pathogenic role of microRNAs in AOSD. MicroRNA profiles in plasma from
Tsai-Ling Liao, Yi-Ming Chen, Chia-Wei Hsieh, Hsin-Hua Chen, Hsiu-Chin Lee, Wei-Ting Hung, Kuo-Tung Tang, Der-Yuan Chen   +7 more
doaj   +1 more source

The Presence of Interleukin 18 Binding Protein Isoforms in Chinese Patients with Rheumatoid Arthritis

AIMS Medical Science, 2016
 Objective: Human IL-18BP gene encodes at least four distinct isoforms (IL18BPa-d) derived by alternative splicing. Their presence in RA local inflammation is not yet examined.
K.E. Khalid, Hamdi Nouri Nsairat, Jingwu Z. Zhang   +2 more
doaj   +1 more source

Genetic basis for variation in plasma IL-18 levels in persons with chronic hepatitis C virus and human immunodeficiency virus-1 infections [PDF]

, 2017
Inflammasomes are multi-protein complexes integrating pathogen-triggered signaling leading to the generation of pro-inflammatory cytokines including interleukin-18 (IL-18).
A Auton, A Iannello, A L Cox, A L French, A Sharma, A Y Kim, AJ Puren, AL Cox, AM Matteini, AY Kim, B Aouizerat, BN Howie, C D Lahiri, C Thio, C Vergara, CA Dinarello, D Gustafson, D L Thomas, D Melzer, D Vlahov, E Golub, E L Murphy, G D Kirk, G Lauer, H Guo, H Jia, J Eron, JZ Liu, K Anastos, K Xia, L Franchi, L Tiret, LH Tobler, LJ Carithers, M Busch, M C Villacres, M G Peters, M He, M Lamkanfi, M Tone, M Young, MA Chattergoon, MA Chattergoon, MG Netea, MH Kuniholm, N Bouzgarrou, N Patterson, NR Roshyara, P Duggal, P Duggal, R Latanich, S H Mehta, S Samarani, S Shrestha, S Wawrocki, SL Normand, SR Thompson, T Strowig, T Zeller, TD Kanneganti, TM Frayling, Y Gu, ZL Niu   +62 more
core   +1 more source

Histologic and molecular features shared between antibody‐mediated rejection of kidney allografts and chronic histiocytic intervillositis support common pathogenesis

The Journal of Pathology, Volume 266, Issue 2, Page 177-191, June 2025.
Abstract Chronic histiocytic intervillositis (CHI) is an inflammatory condition of the placenta, characterised by an abnormal, mainly macrophagic infiltrate within the intervillous space. Recent research suggests that CHI results from a ‘maternal‐foetal rejection’ mechanism, because at least some CHI cases fulfil the criteria for antibody‐mediated ...
Léonie Albersammer, Juliette Leon, Jelena Martinovic, Jessy Dagobert, Emilie Lebraud, Bettina Bessières, Laurence Loeuillet, Maëva Eloudzeri, Alexandre J. Vivanti, Grégoire Dumery, Valérie Marchaudon, Cristina Antal, Anne‐Sophie Korganow, Thibaud Quibel, Nathalie Costedoat‐Chalumeau, Vassilis Tsatsaris, Alexandra Benachi, Julien Zuber, Marion Rabant   +18 more
wiley   +1 more source

Albumin-binding recombinant human IL-18BP ameliorates macrophage activation syndrome and atopic dermatitis via direct IL-18 inactivation

Cytokine, 2023
AbstractGiven the clinical success of cytokine blockade in managing diverse inflammatory human conditions, this approach could be exploited for numerous refractory or uncontrolled inflammatory conditions by identifying novel targets for functional blockade.
Young-Saeng, Jang, Kyungsun, Lee, Mihyun, Park, Jin, Joo Park, Ga Min, Choi, Chohee, Kim, Shima Barati, Dehkohneh, Susan, Chi, Jaekyu, Han, Moo Young, Song, Yong-Hyun, Han, Sang-Hoon, Cha, Seung, Goo Kang   +12 more
openaire   +2 more sources