Results 61 to 70 of about 65,138,242 (275)

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source

IL-21 induces IL-22 production in CD4+ T-cells [PDF]

, 2014
IL-22 produced by innate lymphoid cells (ILCs) and CD4+ T cells plays an important role in host defense and mucosal homeostasis, thus it is important to investigate the mechanisms that regulate IL-22 production.
Nadeau, Meghan, Wu, Chuan, Burns, Evan J., Yeste, Ada, Mascanfroni, Ivan D., Tukpah, Ann-Marcia, Santiago, Andrezza, Patel, Bonny, Kumar, Deepak, Quintana, Francisco   +9 more
core   +1 more source

Characterisation of IL-21 and IL-21Rα in grass carp: IL-21-producing cells are upregulated during Flavobacterium columnare infection

Aquaculture and Fisheries
Interleukin-21 (IL-21) is produced mainly by activated CD4+ T cells and promotes the proliferation, survival and differentiation of immune cells.
Jiawen Xu, Junya Wang, Qingyu Min, Wei Wang, Yuting Qin, Lina Lei, Qian Gao, Jun Zou   +7 more
doaj   +1 more source

The correlation between Th17/Treg immune dysregulation and the disease severity in chronic spontaneous urticaria patients

Immunity, Inflammation and Disease, 2023
Objective Chronic spontaneous urticaria (CSU) has a profound impact on the sleep quality, productivity and overall quality of life of affected individuals.
Xiaojing Yang, Leigang Chen, Shining Wang, Yuanhui Wu, Xiangzhao Zhou, Zhaoying Meng   +5 more
doaj   +1 more source

Interleukins 4 and 21 Protect Anti-IgM Induced Cell Death in Ramos B Cells: Implication for Autoimmune Diseases

Frontiers in Immunology, 2022
Interleukins 4 (IL-4) and 21 (IL-21) belong to the common gamma chain cytokine family which are highly involved in the progression of autoimmune diseases.
Chin Wai Hui, Wai Chung Wu, Shui On Leung   +2 more
doaj   +1 more source

Language, Culture, and Cancer: Qualitative Insights Into Communication Disparities Among Spanish‐Speaking Caregivers of Children With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Latino children are projected to make up nearly one‐third of United States (US) children by 2060, and many of their caregivers speak Spanish. Prior survey research has documented communication difficulties for Spanish‐speaking caregivers of children with cancer, but contemporary qualitative data are limited.
Jenny Ruiz, Alejandra Curbelo‐Paz, Sonia Morales, Elizabeth Contreras, Amy Houtrow, Scott H. Maurer, Judy C. Chang   +6 more
wiley   +1 more source

The Association of the Altered Interleukin-17 and Interleukin-21 Serum Levels with the Occurrence of Autoimmune Thyroid Diseases

Medical Journal of Babylon
Background: Autoimmunity denotes the abnormal attitude where an individual defenses act against its tissues. Objectives: The aim of the current study was to investigate the role of interleukin-17 (IL-17) and interleukin-21 (IL-21) in the occurrence of ...
Hadi Hussein Hamad, Amir Hani Raziq
doaj   +1 more source

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Development and Characterization of IL-21–producing CD4+ T Cells [PDF]

, 2008
It has recently been shown that interleukin (IL)-21 is produced by Th17 cells, functions as an autocrine growth factor for Th17 cells, and plays critical roles in autoimmune diseases. In this study, we investigated the differentiation and characteristics
Nakajima, Hiroshi, Shin-ichiro Kagami, Iwamoto, Itsuo, Hirose, Koichi, Watanabe, Norihiko, Saito, Yasushi, Yokote, Kotaro, Toshinori Nakayama, Yasushi Saito, Itsuo Iwamoto, Kagami, Shin-ichiro, Norihiko Watanabe, Kotaro Yokote, Suto, Akira, Michael J. Grusby, Kashiwakuma, Daisuke, Hiroshi Nakajima, Koichi Hirose, Nakayama, Toshinori, Grusby, Michael, Akira Suto, Daisuke Kashiwakuma   +21 more
core   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source