Innate lymphoid cells exhibited IL-17-expressing phenotype in active tuberculosis disease
BMC Pulmonary Medicine, 2021 Background Innate lymphoid cells (ILCs), as an important group of innate immunity, could respond rapidly to Mycobacterium tuberculosis (Mtb) infection.
Linyue Pan +11 more
doaj +1 more source
Induction of pathogenic Th17 cells by inducible salt sensing kinase SGK1 [PDF]
, 2014 Th17 cells are highly proinflammatory cells critical for clearing extracellular pathogens and for induction of multiple autoimmune diseases1. IL-23 plays a critical role in stabilizing and reinforcing the Th17 phenotype by increasing expression of IL-23 ...
Kishi, Yasuhiro +7 more
core +1 more source
Immunogenicity to biological drugs in psoriasis and psoriatic arthritis
Clinics, 2021 Monoclonal antibodies or fusion proteins, defined as biological drugs, have modified the natural history of numerous immune-mediated disorders, allowing the development of therapies aimed at blocking the pathophysiological pathways of the disease ...
Fernando Valenzuela, Rodrigo Flores
doaj +1 more source
The effect of periodontal therapy on IL-17 and IL-23 in Gingival Crevicular Fluid (GCF) of patients with severe periodontitis [PDF]
Caspian journal of dental research, 2013 Introduction: Cytokines are the important factors in the progression of periodontal diseases. The aim of this study was to find out the effect of the first phase of the periodontal therapy on the amount of existing IL-17 and IL-23 in gingival crevicular ...
Marzieh Rohaninasab +3 more
doaj +2 more sources
The role of IL-23 receptor signaling in inflammation-mediated erosive autoimmune arthritis and bone remodeling [PDF]
, 2017 The IL-23/Th17 axis has been implicated in the development of autoimmune diseases, such as rheumatoid arthritis (RA) and psoriatic arthritis (PsA). RA and PsA are heterogeneous diseases with substantial burden on patients.
Driel, M. (Marjolein) van +2 more
core +2 more sources
IL-17 polarization of MAIT cells is derived from the activation of two different pathways [PDF]
, 2017 MAIT cells are expanded in salivary glands of patients with Sjogren's syndrome and are IL-17 polarized. IL-7 and IL-23 induce IL-17 production activating two different pathways: IL-7 stimulation induces in fact a significant STAT3 and HIF1alpha ...
Alessandro, R. +7 more
core +1 more source
Frontiers in Immunology, 2017 Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis.
Fabrine Sales Massafera Tristão +6 more
doaj +1 more source
INTERLEUKIN (IL) 12, IL-23 AND IL-23 RECEPTOR IN ANKYLOSING SPONDYLITIS PATHOPHYSIOLOGY
Romanian Journal of Rheumatology, 2015 Ankylosing spondylitis (AS) is a chronic inflammatory arthritis which involves mainly the spine and the sacroiliac joints, but also the peripheral joints and non-articular structures. IL-12 and IL-23 are heterodimeric cytokines sharing a common p40 subunit. Studies showed than IL-12 is essential for Th1 differentiation while IL-23 promotes a particular
Marius Cherciu +5 more
openaire +1 more source
IL-23 blockade in a patient with psoriasis and Toxoplasma gondii reactivation history: Case report and review. [PDF]
SAGE Open Med Case RepDagher J, Ringuet J.
europepmc +2 more sources
Evidence that autophagy, but not the unfolded protein response, regulates the expression of IL-23 in the gut of patients with ankylosing spondylitis and subclinical gut inflammation. [PDF]
, 2014 OBJECTIVES: Interleukin (IL)-23 has been implicated in the pathogenesis of ankylosing spondylitis (AS). The aim of the study was to clarify the mechanisms underlying the increased IL-23 expression in the gut of AS patients.
Accardo Palumbo,A +9 more
core +1 more source