Roles of IL-25 in Type 2 Inflammation and Autoimmune Pathogenesis [PDF]
Frontiers in Immunology, 2021 Interleukin-17E (IL-25) is a member of the IL-17 cytokine family that includes IL-17A to IL-17F. IL-17 family cytokines play a key role in host defense responses and inflammatory diseases.
Chong Deng +9 more
doaj +3 more sources
The potential role of interleukin (IL)‐25/IL‐33/thymic stromal lymphopoietin (TSLP) on the pathogenesis of idiopathic pulmonary fibrosis [PDF]
The Clinical Respiratory Journal, 2022 Objectives Interleukin (IL)‐25, IL‐33, and thymic stromal lymphopoietin (TSLP) are the important drivers for excessive type‐2 immunity. It has been well elucidated that IL‐25/IL‐33/TSLP plays an important role in allergic airway inflammation and ...
Xuefeng Xu, Huaping Dai, Jinglan Zhang
doaj +3 more sources
Emerging roles for IL-25 and IL-33 in colorectal cancer tumorigenesis [PDF]
Frontiers in Immunology, 2022 Colorectal cancer (CRC) is the second leading cause of cancer-related death worldwide, and is largely refractory to current immunotherapeutic interventions. The lack of efficacy of existing cancer immunotherapies in CRC reflects the complex nature of the
Eric Jou +2 more
doaj +3 more sources
IL-25 blockade augments antiviral immunity during respiratory virus infection. [PDF]
Commun Biol, 2022 AbstractIL-25 is implicated in the pathogenesis of viral asthma exacerbations. However, the effect of IL-25 on antiviral immunity has yet to be elucidated. We observed abundant expression and colocalization of IL-25 and IL-25 receptor at the apical surface of uninfected airway epithelial cells and rhinovirus infection increased IL-25 expression ...
Williams TC +14 more
europepmc +5 more sources
Assessment of TSLP, IL 25 and IL 33 in patients with shrimp allergy [PDF]
Allergy, Asthma & Clinical Immunology, 2021 Background Shrimp allergy is a growing problem among the European population. TSLP, IL-25 and IL-33 are involved in the pathophysiology of allergic diseases, including asthma and atopic dermatitis, as they activate the Th2-dependent immune response ...
Natalia Ukleja-Sokołowska +4 more
doaj +3 more sources
Interleukin 25 (IL-25) expression in cholangiocarcinoma. [PDF]
Mol Clin Oncol, 2020 Various cytokines are involved in carcinogenesis and tumor progression. Some tumor cells produce cytokines by themselves. Using secretome analysis, a high expression of APEX-1 was found in cholangiocarcinoma (CCA) cell lines. During this secretome analysis, it was found that CCA cell lines overexpressed some cytokines and related molecules, including ...
Kaewsarabhumi S +7 more
europepmc +5 more sources
IL-25 induces airway remodeling in asthma by orchestrating the phenotypic changes of epithelial cell and fibrocyte. [PDF]
Respir Res, 2023 Background Previous studies have shown that IL-25 levels are increased in patients with asthma with fixed airflow limitation (FAL). However, the mechanism by which IL-25 contributes to airway remodeling and FAL remains unclear. Here, we hypothesized that
Yao X, Chen Q, Wang X, Liu X, Zhang L.
europepmc +2 more sources
Exogenous IL-25 ameliorates airway neutrophilia via suppressing macrophage M1 polarization and the expression of IL-12 and IL-23 in asthma. [PDF]
Respir Res, 2023 Background Severe asthma is associated with substantial mortality and has unmet therapeutic need. A subset of severe asthma is characterized by neutrophilic airway inflammation.
Chang C +7 more
europepmc +2 more sources
The IL-25/ILC2 axis promotes lung cancer with a concomitant accumulation of immune-suppressive cells in tumors in humans and mice. [PDF]
Front Immunol, 2023 Background Group 2 innate lymphoid cells (ILC2) can be activated by interleukin (IL)-33 or IL-25. IL-25-activated ILC2 cells help protect the host against helminth infection while exacerbating allergic-like inflammation and tissue damage in the lung.
Bahhar I +7 more
europepmc +2 more sources
Role of IL-25 on Eosinophils in the Initiation of Th2 Responses in Allergic Asthma. [PDF]
Front Immunol, 2022 Background Eosinophils act as a secondary antigen-presenting cell (APC) to stimulate Th cell responses against antigens. IL-25 plays a significant role in eosinophil activation in allergic asthma.
Peng B +7 more
europepmc +2 more sources