IL-31 induces antitumor immunity in breast carcinoma [PDF]
Journal for ImmunoTherapy of Cancer, 2020 Background Immunomodulatory agents that induce antitumor immunity have great potential for treatment of cancer. We have previously shown that interleukin (IL)-31, a proinflammatory cytokine from the IL-6 family, acts as an antiangiogenic agent.
Tal Kan +6 more
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Blockage of the IL-31 Pathway as a Potential Target Therapy for Atopic Dermatitis [PDF]
Pharmaceutics, 2023 Atopic dermatitis (AD), a pruritic, inflammatory chronic disease with multifactorial pathogenesis, has been a therapeutic challenge. Novel target treatments aim to reduce not only the immunologic dysfunction and microbiome dysbiosis but also the recovery
Raquel Leao Orfali, Valeria Aoki
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The role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis [PDF]
Open Life Sciences, 2023 This study was devoted to demonstrating the role of IL-31 and IL-34 in the diagnosis and treatment of chronic periodontitis (CP). From the results, we found that the IL-31 and IL-34 levels were significantly increased in GCF and serum of CP patients ...
Luo Ying, Ding Yi, Chen Yaduo
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The Novel Role of MIF in the Secretion of IL-25, IL-31, and IL-33 from PBMC of Patients with Rheumatoid Arthritis [PDF]
Molecules, 2021 Rheumatoid arthritis (RA) is an autoimmune inflammatory joint disease with complex pathogenesis associated with cytokine dysregulation. Macrophage migration inhibitory factor (MIF) plays a role in systemic inflammation and joint destruction in RA and ...
Samuel García-Arellano +5 more
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Anti-atopic dermatitis effect of fraxinellone via inhibiting IL-31 in vivo and in vitro [PDF]
HeliyonChronic recurrent itch and skin inflammation are prominent features of atopic dermatitis (AD), which is closely related to the immune response driven by T-helper type 2 (Th2) cells.
Niuniu Yang +6 more
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IL-5, IL-31 and systemic immune-inflammation index as biomarkers predicting severity and progression in bullous pemphigoid [PDF]
Frontiers in MedicineIntroductionInflammatory mechanisms assume a pivotal role in bullous pemphigoid (BP). IL-31, IL-5, and the systemic immunoinflammatory index (SII) are emerging markers of inflammatory activity, but their associations with BP severity remain unclear. This
Yanyu Zhang +12 more
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Increased serum IL-31 levels in chronic spontaneous urticaria and psoriasis with pruritic symptoms [PDF]
Heliyon, 2020 Background: Chronic spontaneous urticaria (CSU) is a common pruritic skin condition, the pathogenesis of which remains unclear. Interleukin-31 (IL-31) is a major pruritogenic cytokine that plays a role in inducing pruritus in various skin diseases. Aim.:
Suteeraporn Chaowattanapanit +7 more
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Role of the Pruritic Cytokine IL-31 in Autoimmune Skin Diseases [PDF]
Frontiers in Immunology, 2019 Many autoimmune skin diseases, such as bullous pemphigoid (BP), psoriasis and certain types of chronic urticaria, are associated with intensive pruritus.
Bernhard F. Gibbs +2 more
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Interleukin-31 as a Clinical Target for Pruritus Treatment
Frontiers in Medicine, 2021 In recent years, the published literature has suggested the key involvement of the cytokine interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have become potential therapeutic targets for a range of pruritic ...
Kenji Kabashima, Hiroyuki Irie
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Neurobiology of Pain, 2022 To elucidate the mechanisms underlying the antipruritic effect of capsaicin, we investigated how topical application of capsaicin (0.01, 0.1 and 1.0% w/v) affects spontaneous scratching in NC/Nga mice, inerleukin-31 (IL-31) induced in BALB/c mice, and IL-
Iwao Arai +4 more
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