Results 11 to 20 of about 1,179,733 (270)

New mechanism underlying IL-31–induced atopic dermatitis [PDF]

Journal of Allergy and Clinical Immunology, 2018
TH2 cell-released IL-31 is a critical mediator in patients with atopic dermatitis (AD), a prevalent and debilitating chronic skin disorder. Brain-derived natriuretic peptide (BNP) has been described as a central itch mediator. The importance of BNP in peripheral (skin-derived) itch and its functional link to IL-31 within the neuroimmune axis of the ...
Jianghui Meng, Masaki Moriyama, Micha Feld, Joerg Buddenkotte, Timo Buhl, Attila Szöllösi, Jingming Zhang, Paul Miller, Andre Ghetti, Michael Fischer, Peter W. Reeh, Chunxu Shan, Jiafu Wang, Martin Steinhoff   +13 more
openaire   +6 more sources

IL-33/IL-31 Axis in Osteoporosis. [PDF]

Int J Mol Sci, 2020
The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known.
De Martinis M, Sirufo MM, Suppa M, Ginaldi L.   +3 more
europepmc   +5 more sources

IL-31 and IL-33 in rheumatoid arthritis patients

Научно-практическая ревматология, 2022
Objective – to investigate clinical and diagnostic significance of IL-31 and IL-33 determination in patients with rheumatoid arthritis (RA).Material and methods. 154 patients with a reliable diagnosis of RA were examined.
N. A. Lapkina, A. A. Baranov, N. E. Abaytova, N. Yu. Levshin, O. P. Rechkina, E. A. Leontyeva, A. S. Avdeyeva, A. S. Artyukhov, E. L. Nasonov   +8 more
doaj   +2 more sources

IL-5, IL-31 and systemic immune-inflammation index as biomarkers predicting severity and progression in bullous pemphigoid [PDF]

Frontiers in Medicine
IntroductionInflammatory mechanisms assume a pivotal role in bullous pemphigoid (BP). IL-31, IL-5, and the systemic immunoinflammatory index (SII) are emerging markers of inflammatory activity, but their associations with BP severity remain unclear. This
Yanyu Zhang, Xia Liu, Lili Hou, Yan Zhao, Jiaxuan Hao, Na Zhang, Jing Tian, Xiaoqing Li, Zhiyu Liu, Hongwei Zhou, Chunyang Xu, Yuan Ren, Haizhou Zhou   +12 more
doaj   +2 more sources

IL-31 transgenic mice show reduced allergen-induced lung inflammation. [PDF]

Eur J Immunol, 2021
Abstract Interleukin‐31 (IL‐31) is a Th2 cell–derived cytokine that has been closely linked to pruritic skin inflammation. More recently, enhanced IL‐31 serum levels have also been observed in patients with allergic rhinitis and allergic asthma. Therefore, the main aim of this study was to unravel the contribution
Neuper T, Neureiter D, Sarajlic M, Strandt H, Bauer R, Schwarz H, Suchanek P, Korotchenko E, Dillon SR, Hammerl P, Stoecklinger A, Weiss R, Horejs-Hoeck J.   +12 more
europepmc   +5 more sources

Increased serum IL-31 levels in chronic spontaneous urticaria and psoriasis with pruritic symptoms [PDF]

Heliyon, 2020
Background: Chronic spontaneous urticaria (CSU) is a common pruritic skin condition, the pathogenesis of which remains unclear. Interleukin-31 (IL-31) is a major pruritogenic cytokine that plays a role in inducing pruritus in various skin diseases. Aim.:
Suteeraporn Chaowattanapanit, Charoen Choonhakarn, Kanin Salao, Kengkart Winaikosol, Narachai Julanon, Rachot Wongjirattikarn, Chingching Foocharoen, Mongkhon Sompornrattanaphan   +7 more
doaj   +2 more sources

IL-33/IL-31 Axis in Immune-Mediated and Allergic Diseases. [PDF]

Int J Mol Sci, 2019
Several allergic and immunologic diseases including asthma, food allergy (FA), chronic spontaneous urticaria (CSU), atopic dermatitis (AD), systemic lupus erythematosus (SLE), systemic sclerosis (SSc), rheumatoid arthritis (RA), and Behçet’s disease (BD) are characterized by the involvement of Th2 immunity.
Murdaca G, Greco M, Tonacci A, Negrini S, Borro M, Puppo F, Gangemi S.   +6 more
europepmc   +6 more sources

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31 [PDF]

Experimental Hematology, 2007
Interleukin (IL)-31 is a recently discovered helical cytokine. Its receptor consists of a ligand-specific IL-31 receptor (IL-31R) subunit and a receptor chain that is shared with Oncostatin M (OSM), called OSM-Rbeta. Because OSM-Rbeta-deficient animals have reduced hematopoietic progenitor cells (HPC) and OSM has effects on and is involved in ...
Hal E, Broxmeyer, Ji, Li, Giao, Hangoc, Scott, Cooper, Wen, Tao, Charlie, Mantel, Barbara, Graham-Evans, Nico, Ghilardi, Frederic J, de Sauvage   +8 more
  +7 more sources

IL‐31 and IL‐31 receptor expression in acute experimental canine atopic dermatitis skin lesions [PDF]

Veterinary Dermatology, 2021
BackgroundTo optimise the interleukin (IL)‐31‐blocking therapy in atopic dermatitis (AD), an understanding of the chronology in the expression of IL‐31 and its receptor (IL‐31RA) is needed.Hypothesis/Objectives(i) To assess the chronological expression of IL‐31 in canine AD skin lesions, (ii) to compare it with serum IL‐31 levels and macroscopic skin ...
Chie Tamamoto‐Mochizuki, Thierry Olivry   +1 more
openaire   +2 more sources

Interleukin-31 as a Clinical Target for Pruritus Treatment

Frontiers in Medicine, 2021
In recent years, the published literature has suggested the key involvement of the cytokine interleukin-31 (IL-31) in the symptomatology of pruritus, and both IL-31 and its receptor have become potential therapeutic targets for a range of pruritic ...
Kenji Kabashima, Hiroyuki Irie
doaj   +1 more source