Results 11 to 20 of about 1,155,232 (268)

New mechanism underlying IL-31-induced atopic dermatitis [PDF]

Journal of Allergy and Clinical Immunology, 2018
LBK
Buddenkotte, Joerg, Buhl, Timo, Feld, Micha, Fischer, Michael, Ghetti, Andre, Meng, Jianghui, Miller, Paul, Moriyama, Masaki, Reeh, Peter W., Shan, Chunxu, Steinhoff, Martin, Szöllősi, Attila Gábor, Wang, Jiafu, Zhang, Jingming   +13 more
core   +5 more sources

IL-33/IL-31 Axis: A Potential Inflammatory Pathway [PDF]

Mediators of Inflammation, 2018
Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases.
Eleonora Di Salvo, Elvira Ventura-Spagnolo, Marco Casciaro, Michele Navarra, Sebastiano Gangemi   +4 more
doaj   +7 more sources

IL-31 and IL-33 in rheumatoid arthritis patients

Научно-практическая ревматология, 2022
Objective – to investigate clinical and diagnostic significance of IL-31 and IL-33 determination in patients with rheumatoid arthritis (RA).Material and methods. 154 patients with a reliable diagnosis of RA were examined.
N. A. Lapkina, A. A. Baranov, N. E. Abaytova, N. Yu. Levshin, O. P. Rechkina, E. A. Leontyeva, A. S. Avdeyeva, A. S. Artyukhov, E. L. Nasonov   +8 more
doaj   +2 more sources

IL-31, itch and hematological malignancies. [PDF]

Clin Mol Allergy, 2021
AbstractPruritus is one of the most common symptoms experienced by neoplastic patients. The pathogenesis of neoplastic itch is complex and multifactorial and could be due to an unbalanced production of humoral mediators by altered immune effector cells. IL-31 is a pro-inflammatory cytokine produced by CD4 + T helper cells. The aim of this review was to
Di Salvo E, Allegra A, Casciaro M, Gangemi S.   +3 more
europepmc   +5 more sources

The molecular basis for IL-31 production and IL-31-mediated itch transmission: from biology to drug development. [PDF]

Int Immunol, 2021
Abstract Atopic dermatitis (AD) is one of the most prevalent chronic inflammatory skin diseases in the world. It is characterized by recurrent eczematous lesions and intense itch, and many cytokines are involved in the pathogenesis of AD. Among them, much attention has been paid to interleukin 31 (IL-31) as an AD-associated itch mediator.
Kunimura K, Fukui Y.
europepmc   +4 more sources

IL-31/33 Axis in Atopic Dermatitis. [PDF]

Int J Mol Sci
Atopic dermatitis (AD) is a chronic inflammatory skin disorder characterized by impaired epidermal barrier function, immune dysregulation (e.g., Th2 polarization), genetic factors (e.g., filaggrin mutations), environmental triggers and microbial dysbiosis, leading to pruritus and eczematous lesions.
Łacwik J, Kraik K, Laska J, Tota M, Sędek Ł, Gomułka K.   +5 more
europepmc   +4 more sources

Significance of interleukin-31 (IL-31) gene polymorphisms and IL-31 serum level in psoriasis in correlation with pruritus. [PDF]

Postepy Dermatol Alergol, 2021
Interleukin-31 (IL-31) impact on the development and clinical presentation of psoriasis as well as pruritus has not been widely investigated so far.To analyse IL-31 -1066G/A and -2057G/A promoter gene polymorphisms as well as serum IL-31 level and their correlation with severity of psoriasis and pruritus in the population of northern Poland.The study ...
Purzycka-Bohdan D, Gleñ J, Zabłotna M, Nedoszytko B, Szczerkowska-Dobosz A, Sokołowska-Wojdyło M, Rêbała K, Nowicki RJ.   +7 more
europepmc   +4 more sources

Regulation of myeloid progenitor cell proliferation/survival by IL-31 receptor and IL-31 [PDF]

Experimental Hematology, 2007
Interleukin (IL)-31 is a recently discovered helical cytokine. Its receptor consists of a ligand-specific IL-31 receptor (IL-31R) subunit and a receptor chain that is shared with Oncostatin M (OSM), called OSM-Rbeta. Because OSM-Rbeta-deficient animals have reduced hematopoietic progenitor cells (HPC) and OSM has effects on and is involved in ...
Hal E, Broxmeyer, Ji, Li, Giao, Hangoc, Scott, Cooper, Wen, Tao, Charlie, Mantel, Barbara, Graham-Evans, Nico, Ghilardi, Frederic J, de Sauvage   +8 more
  +7 more sources

IL‐31 and IL‐31 receptor expression in acute experimental canine atopic dermatitis skin lesions [PDF]

Veterinary Dermatology, 2021
BackgroundTo optimise the interleukin (IL)‐31‐blocking therapy in atopic dermatitis (AD), an understanding of the chronology in the expression of IL‐31 and its receptor (IL‐31RA) is needed.Hypothesis/Objectives(i) To assess the chronological expression of IL‐31 in canine AD skin lesions, (ii) to compare it with serum IL‐31 levels and macroscopic skin ...
Chie Tamamoto‐Mochizuki, Thierry Olivry   +1 more
openaire   +2 more sources

IL-33/IL-31 Axis in Osteoporosis. [PDF]

Int J Mol Sci, 2020
The study of the immunoskeletal interface has led to the discovery of numerous cytokines involved in the regulation of bone remodeling, providing valuable information on the pathogenesis of osteoporosis. The role of inflammatory cytokines of the Th1 and Th17 profile in osteoporosis is well known.
De Martinis M, Sirufo MM, Suppa M, Ginaldi L.   +3 more
europepmc   +5 more sources