Results 121 to 130 of about 1,106,140 (286)

Group 2 innate lymphoid cells exhibit a dynamic phenotype in allergic airway inflammation [PDF]

, 2017
Group 2 innate lymphoid cells (ILC2) are implicated in allergic asthma as an early innate source of the type 2 cytokines IL-5 and IL-13. However, their induction in house dust mite (HDM)-mediated airway inflammation additionally requires T cell ...
Beerens, D.M.J.M. (Dior), Bergen, I.M. (Ingrid), Brem, M.D. (Maarten), Bruijn, M.J.W. (Marjolein) de, Fehling, H.J. (Hans Jörg), Hendriks, R.W. (Rudi), IJcken, W.F.J. (Wilfred) van, Kleinjan, A. (Alex), Kool, M. (Mirjam), Li, B.W.S. (Bobby), Lukkes, M. (Melanie), Rao, T.N. (Tata Nageswara), Stadhouders, R. (Ralph), Vroman, H. (Heleen)   +13 more
core   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

INFLAMMASOME NLRP1 DISTINCTIVE FEATURES IN ATOPIC CONDITIONS

Медицина в Кузбассе, 2023
The review article focuses on the NLRP1 inflammasome, which was discovered before the others but has been the least investigated. The emergence of the inflammasome in innate immunity container cells is an early event that precedes the development of any ...
Денис Сергеевич Загрешенко, Андрей Владимирович Климов, Владимир Васильевич Климов, Наталья Сергеевна Кошкарова, Оксана Анатольевна Найдина, Екатерина Юрьевна Цыплина   +5 more
doaj  

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Inception of early-life allergen–induced airway hyperresponsiveness is reliant on IL-13+CD4+ T cells [PDF]

, 2018
Airway hyperresponsiveness (AHR) is a critical feature of wheezing and asthma in children, but the initiating immune mechanisms remain unconfirmed.
Branchett, WJ, Buckley, JS, Bush, A, Byrne, A, Denney, L, Entwhistle, LJ, Fainardi, V, Gregory, LG, Grychtol, R, Lloyd, CM, Lui, S, Manghera, AK, Oliver, RA, Puttur, F, Saglani, S, Sherburn, R, Uwadiae, F, Vasiliou, JE, von Mutius, E, Vöhringer, D, Walker, SA   +20 more
core   +2 more sources

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Interleukins IL33/ST2 and IL1-β in Intrauterine Growth Restriction and Seropositivity of Anti-Toxoplasma gondii Antibodies

Microorganisms
Toxoplasma gondii (T. gondii) is the causal agent of toxoplasmosis. It may produce severe damage in immunocompromised individuals, as well as congenital infection and intrauterine growth restriction (IUGR). Previous reports have associated interleukin IL-
Karen Franco-De León, Eva Elizabeth Camarena, Ana Laura Pereira-Suárez, Ernesto Barrios-Prieto, Andrea Soto-Venegas, Zamira Helena Hernández-Nazara, Yithzel Guadalupe Luna Rojas, María de la Luz Galván-Ramírez   +7 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye [PDF]

, 2017
Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization.
Campbell, M, Copland, DA, Dick, AD, Doyle, SL, Gardner, PJ, Liu, J, Ozaki, E, Theodoropoulou, S, Wu, J   +8 more
core  

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source