Results 131 to 140 of about 1,087,614 (283)

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

IL-33/IL-31 Axis: A Potential Inflammatory Pathway

Mediators of Inflammation, 2018
Cytokines play an important role in the regulation of the immune system (adaptive and innate). Given their importance in proinflammatory processes, cytokines have been used for understanding the pathogenesis and as biomarkers in many diseases.
Eleonora Di Salvo, Elvira Ventura-Spagnolo, Marco Casciaro, Michele Navarra, Sebastiano Gangemi   +4 more
doaj   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Behçet hastalığında serum IL-33 düzeyi ve IL-33 gen polimorfizmleri

, 2020
Tekrarlayıcı mukokutanöz, oküler, kas-iskelet, gastrointestinal ve santral sinir sistem tutulumları ile karakterize, inflamatuar bir hastalık olan Behçet hastalığı (BH), ülkemizin de içinde bulunduğu bazı coğrafik alanlarda sık görülmektedir. Etiyopatogenezi tam olarak aydınlatılamamış olsa da immün aktivasyon, IL-1ß düzeyinde artış ve IL-1 gen ...
openaire   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

CREB regulates Foxp3+ST-2+ TREGS with enhanced IL-10 production

Frontiers in Immunology
IntroductionRegulatory T-cells (Tregs) are characterized by the expression of Foxp3, a master regulator involved in the development and function of Tregs.
Sudheendra Hebbar Subramanyam, Judit Turyne Hriczko, Saskia Schulz, Thomas Look, Thomas Look, Tannaz Goodarzi, Tim Clarner, Miriam Scheld, Markus Kipp, Eva Verjans, Svenja Böll, Christopher Neullens, Ivan Costa, Zhijian Li, Lin Gan, Bernd Denecke, Angela Schippers, Stefan Floess, Jochen Huehn, Edgar Schmitt, Tobias Bopp, Hermann Wasmuth, Ron Winograd, Rudi Beyaert, Rudi Beyaert, Bart Lambrecht, Bart Lambrecht, Martin Zenke, Martin Zenke, Martin Zenke, Martin Zenke, Norbert Wagner, Kim Ohl, Klaus Tenbrock, Klaus Tenbrock   +34 more
doaj   +1 more source

Longitudinal changes in the expression of IL-33 and IL-33 regulated genes in relapsing remitting MS.

PLoS ONE, 2018
OBJECTIVE:We tested the hypothesis that the expression of IL-33 in MS is dynamic and is likely to reflect the clinical and radiological changes during the course of RRMS.
Subramaniam Sriram, Guzel Shaginurova, John T Tossberg, Chandramohan Natarajan, Charles F Spurlock, Thomas M Aune   +5 more
doaj   +1 more source

Interleukin-33 regulates tissue remodelling and inhibits angiogenesis in the eye [PDF]

, 2017
Age-related macular degeneration (AMD) is the leading cause of central vision loss worldwide. Loss of retinal pigment epithelium (RPE) is a major pathological hallmark in AMD with or without pathological neovascularization.
Campbell, M, Copland, DA, Dick, AD, Doyle, SL, Gardner, PJ, Liu, J, Ozaki, E, Theodoropoulou, S, Wu, J   +8 more
core  

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source