Results 61 to 70 of about 7,173,757 (221)

High interleukin-35 expression is associated with the severity of rheumatic mitral stenosis

Frontiers in Immunology
BackgroundRheumatic mitral stenosis (RMS) is the most common manifestation of rheumatic heart disease, with high morbidity and mortality. Interleukin-35 (IL-35) is a novel anti-inflammatory cytokine associated with many autoimmune diseases.
Ping Wang, Yaxiong Li, Li Zhao, Bin Liu, Zhibin Cai, Peng Zhang, Peng Li, Xuezhen Gao, Yong Zhan   +8 more
doaj   +1 more source

Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.

, 2014
Interleukin-35 (IL-35), a cytokine from the Interleukin-12 cytokine family, has been considered as an anti-inflammatory cytokine which promotes tumor progression and tumor immune evasion. It has also been demonstrated that IL-35 is secreted by regulatory
Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman, Kang-Ling Liao, Avner Friedman, Bai Xue-Feng, Liao Kang-Ling, Xue-Feng Bai, Friedman Avner   +6 more
core   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

IL-35: a new immunomodulator in autoimmune rheumatic diseases

, 2018
IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35.
Mavropoulos A., Perricone C., Sakkas L. I., Bogdanos D. P.   +3 more
core   +2 more sources

CD27 and IL-35 as diagnostic biomarkers in alopecia areata: First evidence of association with pathogenic scalp bacterial infections

Babcock University Medical Journal
Objective: This study aimed to investigate the diagnostic and prognostic potential of CD27 and interleukin-35 (IL-35) in patients with Alopecia Areata (AA), with and without pathogenic bacterial infections.
Sura Mohammed Shakir, Layla Saleh Abdul-Hassan   +1 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Breast cancer cell-derived IL-35 promotes tumor progression via induction of IL-35-producing induced regulatory T cells

, 2018
Interleukin 35 (IL-35) is a potent immunosuppressive cytokine, consisting of an Epstein-Barr virus-induced gene 3 (EBI3) subunit and a p35 subunit.
Wang, Fang, Liu, Jia, Yuan, Chao, Hao, Shengnan, Shao, Qianqian, Chen, Xi, Zhao, Hui, Ren, Hanxiao, Mao, Haiting   +8 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Determination of Interleukin-35 in Sera of Male Patients with Chronic Renal Failure on Hemodialysis

Diyala Journal of Medicine, 2019
Background:- Renal failure may lead to increased inflammatory responses through a number of mechanisms which include decreased clearance of proinflammatory cytokines, decreased levels of antioxidant , that lead to increase of oxidative stress , nephrons
Salma Abdul Rudha Abbas
doaj   +2 more sources