The distinct role of IL-34 and IL-35 in gastric cancer [PDF]
Frontiers in ImmunologyGastric cancer (GC) remains a major challenge due to its high mortality and morbidity, despite extensive research. Dysregulated host immunity plays a critical role in carcinogenesis, particularly among susceptible cohorts.
Zhiyun He +6 more
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IL-35, IL-37, and IL-38 in acute pancreatitis: proposed immunopathogenic mechanisms and therapeutic potential [PDF]
Frontiers in ImmunologyAcute pancreatitis (AP) is driven by premature enzyme activation, pancreatic tissue injury, and dysregulated immune responses. IL-35 and IL-37 are key anti-inflammatory mediators whose dynamic regulation influences disease severity.
Hailong Yan +6 more
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Divergent roles of IL-35 and IL-39 in rheumatoid arthritis: restoring cytokine balance within the IL-12 family [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic autoimmune disease characterised by persistent synovial inflammation, progressive cartilage destruction, and irreversible bone erosion.
Xingyan Ling +4 more
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Expression and significance of IL-27 and IL-35 in orbital fat in patients with severe TAO [PDF]
Diagnostic PathologyTo detect the expression of Interleukin-27 (IL-27) and Interleukin-35 (IL-35) in orbital fat in patients with severe TAO (thyroid-related eye disease) exophthalmos, and to investigate its potential role and significance in the development of TAO. A study
Bing Wang +4 more
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The Shared IL‐12/IL‐35 p35 Subunit Is Associated With Heightened Atherogenic Risk in African Patients With Type 2 Diabetes [PDF]
Endocrinology, Diabetes & MetabolismIntroduction Interleukin (IL)‐12 and IL‐35 are heterodimeric cytokines that share the p35 subunit and have opposing inflammatory roles. Dysregulated IL‐12/IL‐35 p35 may reflect an imbalance between pro‐ and anti‐inflammatory pathways linking metabolic ...
Tawanda M. Nyambuya +3 more
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The role of IL-35 and IL-37 in breast cancer – potential therapeutic targets for precision medicine [PDF]
Frontiers in Oncology, 2022 Breast cancer is still a major concern due to its relatively poor prognosis in women, although there are many approaches being developed for the management of breast cancer.
Yuntao Ma +7 more
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Role of serum IL-35 levels in patients with benign and malignant primary ovarian tumors: a case-control study [PDF]
Scientific ReportsIL-35 is known to enhance tumor progression by promoting angiogenesis, increasing cancer cell proliferation, and facilitating immune suppression. Elevated levels of IL-35 have been correlated with the severity of malignancy and clinical stage in various ...
Leila Kiani +8 more
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The circulating IL‐35+ regulatory B cells are associated with thyroid associated opthalmopathy [PDF]
Immunity, Inflammation and DiseaseBackground Thyroid‐associated ophthalmopathy (TAO) is the most common orbital disease in adults, potentially leading to disfigurement and visual impairment. However, the causes of TAO are not fully understood.
Qian Li +8 more
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Decreased Expression of IL‐35 and Its Receptor Contributes to Impaired Megakaryopoiesis in the Pathogenesis of Immune Thrombocytopenia [PDF]
Advanced ScienceRecent findings have shown that the level of interleukin‐35 (IL‐35) is abnormal in several autoimmune diseases. Nonetheless, whether IL‐35 participates in the pathogenesis of immune thrombocytopenia (ITP) remains unclear.
Xuan Cai +6 more
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Association between IL-35 Gene Single Nucleotide Polymorphisms and Systemic Lupus Erythematosus in Egypt [PDF]
Al-Azhar International Medical Journal, 2022 Background: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease characterised by a reduced immune tolerance of the body's immune system and an enormous production of autoantibodies, which ultimately cause damage to most of body ...
Hasan Awaad +3 more
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