IL-35 enhances IL-10⁺ breg-mediated immunoregulation and attenuates inflammation and fibrosis in systemic sclerosis [PDF]
Arthritis Res TherObjective This study aimed to explore the role of interleukin-35 (IL-35)-mediated regulatory B cells (Bregs) in modulating inflammation and fibrosis in systemic sclerosis (SSc).
Wang, Xu +17 more
core +2 more sources
The distinct role of IL-34 and IL-35 in gastric cancer [PDF]
Frontiers in ImmunologyGastric cancer (GC) remains a major challenge due to its high mortality and morbidity, despite extensive research. Dysregulated host immunity plays a critical role in carcinogenesis, particularly among susceptible cohorts.
Zhiyun He +6 more
doaj +2 more sources
Impaired Regulation by IL-35 in Systemic Sclerosis [PDF]
Int J Mol Sci, 2023 This study investigated the role of IL-35 in systemic sclerosis (SSc) patients, focusing on CD4+ T cell response and immunomodulatory cytokine production.
Osuna Gómez, Rubén +19 more
core +3 more sources
IL-35, IL-37, and IL-38 in acute pancreatitis: proposed immunopathogenic mechanisms and therapeutic potential [PDF]
Frontiers in ImmunologyAcute pancreatitis (AP) is driven by premature enzyme activation, pancreatic tissue injury, and dysregulated immune responses. IL-35 and IL-37 are key anti-inflammatory mediators whose dynamic regulation influences disease severity.
Hailong Yan +6 more
doaj +2 more sources
Divergent roles of IL-35 and IL-39 in rheumatoid arthritis: restoring cytokine balance within the IL-12 family [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic autoimmune disease characterised by persistent synovial inflammation, progressive cartilage destruction, and irreversible bone erosion.
Xingyan Ling +4 more
doaj +2 more sources
Expression and significance of IL-27 and IL-35 in orbital fat in patients with severe TAO [PDF]
Diagnostic PathologyTo detect the expression of Interleukin-27 (IL-27) and Interleukin-35 (IL-35) in orbital fat in patients with severe TAO (thyroid-related eye disease) exophthalmos, and to investigate its potential role and significance in the development of TAO. A study
Bing Wang +4 more
doaj +2 more sources
The Shared IL‐12/IL‐35 p35 Subunit Is Associated With Heightened Atherogenic Risk in African Patients With Type 2 Diabetes [PDF]
Endocrinology, Diabetes & MetabolismIntroduction Interleukin (IL)‐12 and IL‐35 are heterodimeric cytokines that share the p35 subunit and have opposing inflammatory roles. Dysregulated IL‐12/IL‐35 p35 may reflect an imbalance between pro‐ and anti‐inflammatory pathways linking metabolic ...
Tawanda M. Nyambuya +3 more
doaj +2 more sources
IL-35 Ameliorates Myocardial Strain in Mice with T2DM-Induced Cardiac Injury: Assessment by Layer-Specific Strain [PDF]
Diabetes Metab Syndr ObesZiying Wang,1,* Leilei Han,2,* Mingyi Dong,3 Yunman Liu,2 Xiangsui Hu,1 Long Huang,4 Chunquan Zhang,1 Liangyun Guo,1 Shengbo Liu,5 Lingmin Liao1 1Department of Ultrasound, The Second Affiliated Hospital, Jiangxi Medical College, Nanchang ...
Liu Y +9 more
core +2 more sources
Role of serum IL-35 levels in patients with benign and malignant primary ovarian tumors: a case-control study [PDF]
Scientific ReportsIL-35 is known to enhance tumor progression by promoting angiogenesis, increasing cancer cell proliferation, and facilitating immune suppression. Elevated levels of IL-35 have been correlated with the severity of malignancy and clinical stage in various ...
Leila Kiani +8 more
doaj +2 more sources
The circulating IL‐35+ regulatory B cells are associated with thyroid associated opthalmopathy [PDF]
Immunity, Inflammation and DiseaseBackground Thyroid‐associated ophthalmopathy (TAO) is the most common orbital disease in adults, potentially leading to disfigurement and visual impairment. However, the causes of TAO are not fully understood.
Qian Li +8 more
doaj +2 more sources