Elevated serum IL-35 and increased expression of IL-35-p35 or -EBI3 in CD4(+)CD25(+) T cells in patients with active tuberculosis. [PDF]
, 2016 Despite the recent appreciation of interleukin 35 (IL-35) function in inflammatory diseases, little is known for IL-35 response in patients with active tuberculosis (ATB).
JX Zhong (7947023) +13 more
core +4 more sources
Decreased Expression of IL‐35 and Its Receptor Contributes to Impaired Megakaryopoiesis in the Pathogenesis of Immune Thrombocytopenia [PDF]
Advanced ScienceRecent findings have shown that the level of interleukin‐35 (IL‐35) is abnormal in several autoimmune diseases. Nonetheless, whether IL‐35 participates in the pathogenesis of immune thrombocytopenia (ITP) remains unclear.
Xuan Cai +6 more
doaj +2 more sources
The effects of IL-27 and IL-35 gene variation and expression levels on the susceptibility and clinical manifestations of pulmonary tuberculosis [PDF]
Frontiers in ImmunologyInflammatory cytokines have crucial roles in the pathogenesis of tuberculosis (TB), and interleukin (IL)-27 and IL-35 have a pro-inflammatory and anti-inflammatory effect on many diseases, including infectious diseases.
Lei Gao +9 more
doaj +2 more sources
At Embryo Implantation Site IL-35 Secreted by Trophoblast, Polarizing T Cells towards IL-35+ IL-10+ IL-4+ Th2-Type Cells, Could Favour Fetal Allograft Tolerance and Pregnancy Success [PDF]
, 2022 We investigated the role of rhIL-35, at low concentrations compatible with those produced by human trophoblast cells (less than 1 ng/mL), on human T helper (Th) cell functions and the presence of decidual IL-35-producing Th cells in human pregnancy.
Kullolli, O. +19 more
core +1 more source
The role of IL-27 and IL-35 in inflammatory diseases [PDF]
, 2008 Rheumatoid arthritis (RA) is an inflammatory autoimmune disease characterized by chronic inflammation within the synovial tissues in multiple joints leading to progressive, erosive destruction of cartilage and underlying joints.
Cai, BeiLei
core +6 more sources
The role of IL-35 and IL-37 in breast cancer – potential therapeutic targets for precision medicine
Frontiers in Oncology, 2022 Breast cancer is still a major concern due to its relatively poor prognosis in women, although there are many approaches being developed for the management of breast cancer.
Yuntao Ma +7 more
doaj +1 more source
Delivery of IL-35 by Lactococcus lactis Ameliorates Collagen-Induced Arthritis in Mice
Frontiers in Immunology, 2018 IL-35, a relatively newly discovered cytokine belonging to the larger IL-12 family, shows unique anti-inflammatory properties, believed to be associated with dedicated receptors and signaling pathways.
Massimo Maddaloni +3 more
doaj +1 more source
Abnormal expression of CXCL13, MIF and IL-35 in patients with primary Sjögren’s syndrome and its relationship with disease severity [PDF]
Central European Journal of Immunology, 2023 Ronghua Wang +4 more
doaj +2 more sources
Interleukin-35 Expression in Non-Small Cell Lung Cancer is Associated with Tumor Progression
Cellular Physiology and Biochemistry, 2018 Background/Aims: Lung cancer continues to be the leading cause of cancer related deaths worldwide due to its high incidence, malignant behavior and lack of major advancements in treatment strategy. The occurrence and development of lung cancer is closely
Mingfei Sun +9 more
doaj +1 more source
Interleukin (IL)-35 is raising our expectations [PDF]
, 2010 Purpose: To elucidate and discuss the role of IL-35 in immunity to parasitic and bacterial infections as well as in autoimmunity in terms of its anti-infammatory properties, we highlight significant findings on this novel member of the IL-12 family ...
NING-WEI,ZHAO +2 more
core +1 more source