Results 41 to 50 of about 66,774,926 (220)

CD3+CD4+gp130+ T Cells Are Associated With Worse Disease Activity in Systemic Lupus Erythematosus Patients

Frontiers in Immunology, 2021
The receptors for IL-35, IL-12Rβ2 and gp130, have been implicated in the inflammatory pathophysiology of autoimmune diseases. In this study, we set out to investigate the serum IL-35 levels and the surface levels of IL-12Rβ2 and gp130 in CD3+CD4+, CD3 ...
Nur Diyana Mohd Shukri, Nur Diyana Mohd Shukri, Aziz Farah Izati, Aziz Farah Izati, Wan Syamimee Wan Ghazali, Wan Syamimee Wan Ghazali, Che Maraina Che Hussin, Che Maraina Che Hussin, Kah Keng Wong, Kah Keng Wong   +9 more
doaj   +1 more source

Early Body Mass Index z‐Score Change and Resolution of Severe Malnutrition in Children With Sickle Cell Anemia in a Low‐Income Setting: A Prospective Single‐Arm Extension Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Children with sickle cell anemia (SCA) in low‐income settings are at risk of severe malnutrition, but optimal nutritional management has not been established. We evaluated an intensified ready‐to‐use therapeutic food (RUTF) regimen in children with persistent severe malnutrition after initial treatment and assessed whether early ...
Safiya Gambo, Shehu Umar Abdullahi, Hassan Adam Murtala, Halima Kabir, Khadija A. Shamsu, Sari A. Acra, Virginia A. Stallings, Mark Rodeghier, Michael R. DeBaun, Lauren J. Klein   +9 more
wiley   +1 more source

Mathematical modeling of Interleukin-35 promoting tumor growth and angiogenesis.

, 2014
Interleukin-35 (IL-35), a cytokine from the Interleukin-12 cytokine family, has been considered as an anti-inflammatory cytokine which promotes tumor progression and tumor immune evasion. It has also been demonstrated that IL-35 is secreted by regulatory
Kang-Ling Liao, Xue-Feng Bai, and Avner Friedman, Kang-Ling Liao, Avner Friedman, Bai Xue-Feng, Liao Kang-Ling, Xue-Feng Bai, Friedman Avner   +6 more
core   +1 more source

IL-12 family cytokines and autoimmune diseases: A potential therapeutic target?

Journal of Translational Autoimmunity
In recent years, the discovery of IL-12 family cytokines, which includes IL-12, IL-23, IL-27, IL-35, and IL-39, whose biological functions directly or indirectly affect various autoimmune diseases.
Xiaoyu Cui, Wu Liu, Hanxue Jiang, Qihan Zhao, Yuehong Hu, Xinyue Tang, Xianli Liu, Haoran Dai, Hongliang Rui, Baoli Liu   +9 more
doaj   +1 more source

Decreased serum levels of IL-27and IL-35 in patients with Graves disease

Archives of Endocrinology and Metabolism, 2020
Objectives Graves’ disease (GD) is an autoimmune disease causing the overproduction of the thyroid hormone from thyroid gland. This disease is mainly the result of the production of antibodies against TSH receptors.
Malek-Hosseini Saeed, Kalantar Kurosh, Amirghofran Zahra, Dabbaghmanesh Mohamad Hossein, Rostamzadeh Davood, Mohammad Reza Ataollahi   +5 more
doaj   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

IL-35: a new immunomodulator in autoimmune rheumatic diseases

, 2018
IL-35 is a relatively new cytokine that emerges as an important immunomodulator. IL-35 belongs to IL-12 cytokine family that includes IL-12, IL-23, IL-27, and IL-35.
Mavropoulos A., Perricone C., Sakkas L. I., Bogdanos D. P.   +3 more
core   +2 more sources

Pathogenesis and Function of Interleukin-35 in Rheumatoid Arthritis

Frontiers in Pharmacology, 2021
It is well known that RA (Rheumatoid arthritis) is an autoimmune disease characterized by multiple and symmetric arthropathy. The main pathological features of RA are synovial hyperplasia, angiogenesis, pannus formation, inflammatory cell infiltration ...
Pan Lin Xin, Li Fan Jie, Qian Cheng, Du Yi Bin, Cheng Wen Dan   +4 more
doaj   +1 more source

Social Functioning Within the First Years After Pediatric Brain Tumor Diagnosis and the Relationship With Family Psychosocial Risk

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Survivors of pediatric brain tumors (PBTs) can experience long‐term social difficulties, impacting quality of life. Beyond medical and environmental factors, family psychosocial risk may play a role in social outcomes by shaping the caregiving environment and may provide intervention options.
Renske H. Houben, Marisa H. Huisman, Martha A. Grootenhuis, Femke K. Aarsen, Marita Partanen   +4 more
wiley   +1 more source

Recombinant p35 from bacteria can form Interleukin (IL-)12, but Not IL-35. [PDF]

, 2014
The Interleukin (IL)-12 family contains several heterodimeric composite cytokines which share subunits among each other. IL-12 consists of the subunits p40 (shared with IL-23) and p35.
Samadhi Aparicio-Siegmund, Joachim Grötzinger, Philipp A Lang, Juliane Lokau, Melanie Grusdat, Jutta Schröder, Svenja Plöhn, Jürgen Scheller, Christoph Garbers, Stefan Rose-John, Jens M Moll   +10 more
core   +1 more source