Results 41 to 50 of about 1,034,039 (274)

Role of interleukin-36 in kidney disease

Linchuang shenzangbing zazhi, 2023
As an important member of IL-1 family, interleukin 36 (IL-36) is a key regulator of inflammation. Its proinflammatory agonists are composed of IL-36α, IL-36β and IL-36γ while its antagonists include IL-36Ra and IL-38.
Bi-xia Yang, Hua Zhou, Min Yang
doaj   +1 more source

A step towards testing general relativity using weak gravitational lensing and redshift surveys [PDF]

, 2009
Using the linear theory of perturbations in General Relativity, we express a set of consistency relations that can be observationally tested with current and future large scale structure surveys.
A. Cooney, A.J. Albrecht ., C. Quercellini, E. Bertschinger, G.-B. Zhao, G.M. Bernstein, J.B. Dent, L. Amendola, L. Fu ., L.P. Gamberg, M. Kilbinger ., M. White, N. Benitez ., N. Kaiser, O. Dore ., O. Doré, Olivier Doré, P. Zhang, R. Durrer, R. Gannouji, S. Nojiri, S.A. Thomas, SDSS collaboration, Supernova Search Team collaboration, WMAP collaboration, Y.-S. Song, Y.-S. Song, Y.-S. Song, Y.-S. Song, Yong-Seon Song, Z.-M. Ma   +30 more
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Review of the “Routledge Handbook of Philosophy of Sex and Sexuality”

Philosophies, 2023
This paper is a review essay of the recently published Routledge Handbook of Philosophy of Sex and Sexuality, edited by Brian D. Earp, Clare Chambers, and Lori Watson (2022). The anthology consists of an introduction and 40 essays, and it has eight parts:
Raja Halwani
doaj   +1 more source

Comparative Analysis of Single-Cell Transcriptome Data Reveals a Novel Role of Keratinocyte-Derived IL-23 in Psoriasis

Frontiers in Immunology, 2022
Psoriasis, a common inflammatory skin disease, is critically dependent on the IL-23/IL-17 cytokine axis. Although immune cell-derived IL-23 is generally associated with the disease pathogenesis, there have been reports of IL-23 production in ...
Young Joon Park, Yul Hee Kim, Eun-So Lee, You Chan Kim   +3 more
doaj   +1 more source

Differential interaction of glimepiride and glibenclamide with the β-cell sulfonylurea receptor II [PDF]

, 1994
Glimepiride is a novel sulfonylurea for the treatment of type II-diabetic patients exhibiting different receptor binding kinetics to β-cell membranes with 8–9-fold higher koff rate and 2.5–3-fold higher kon rate compared to glibenclamide (see ...
Aguilar-Bryan, Aguilar-Bryan, Ashcroft, Bayley, De Weille, Ehle, Galizzi, Geisen, Geisen, Glossmann, Glossmann, Hogg, Hollemans, Kramer, Kramer, Kramer, Kramer, Martyr, Müller, Nelson, Nelson, Niki, Ozanne, Panten, Pomerantz, Repke, Schmid-Antomarchi, Schwanstecher, Skeer, Wessel   +29 more
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Highlighting Interleukin-36 Signalling in Plaque Psoriasis and Pustular Psoriasis

Acta Dermato-Venereologica, 2017
Plaque psoriasis and pustular psoriasis are overlapping, but distinct, disorders. The therapeutic response to biologics supports the pivotal role of the tumour necrosis alpha (TNF-?)/ interleukin (IL)-23/IL-17/IL-22 axis in the pathogenesis of these ...
Kazuhisa Furue, Kazuhiko Yamamura, Gaku Tsuji, Chikage Mitoma, Hiroshi Uchi, Takeshi Nakahara, Makiko Kido-Nakahara, Takafumi Kadono, Masutaka Furue   +8 more
doaj   +1 more source

Designed DNA-Encoded IL-36 Gamma Acts as a Potent Molecular Adjuvant Enhancing Zika Synthetic DNA Vaccine-Induced Immunity and Protection in a Lethal Challenge Model

Vaccines, 2019
Identification of novel molecular adjuvants which can boost and enhance vaccine-mediated immunity and provide dose-sparing potential against complex infectious diseases and for immunotherapy in cancer is likely to play a critical role in the next ...
Lumena Louis, Megan C. Wise, Hyeree Choi, Daniel O. Villarreal, Kar Muthumani, David B. Weiner   +5 more
doaj   +1 more source

The Origin and Development of Prison Fellowship International: Pluralism, Ecumenism and American Leadership in the Evangelical World 1974–2006 [PDF]

, 2017
Established in 1979 by Watergate felon Charles Colson, Prison Fellowship International (PFI) is now one of the largest para-church organizations in world evangelicalism.
Kendrick Oliver
core   +2 more sources

Cutting Edge: IL-36 Receptor Promotes Resolution of Intestinal Damage [PDF]

The Journal of Immunology, 2016
Abstract IL-1 family members are central mediators of host defense. In this article, we show that the novel IL-1 family member IL-36γ was expressed during experimental colitis and human inflammatory bowel disease. Germ-free mice failed to induce IL-36γ in response to dextran sodium sulfate (DSS)-induced damage, suggesting that gut ...
Oscar Medina-Contreras, Akihito Harusato, Hikaru Nishio, Kyle L Flannigan, Vu Ngo, Giovanna Leoni, Philipp-Alexander Neumann, Duke Geem, Loukia N Lili, Ravisankar A Ramadas, Benoit Chassaing, Andrew T Gewirtz, Jacob E Kohlmeier, Charles A Parkos, Jennifer E Towne, Asma Nusrat, Timothy L Denning   +16 more
openaire   +2 more sources

IL-36 Promotes Systemic IFN-I Responses in Severe Forms of Psoriasis [PDF]

Journal of Investigative Dermatology, 2020
Psoriasis is an immune-mediated skin disorder associated with severe systemic co-morbidities. While IL-36 is a key disease driver, the pathogenic role of this cytokine has mainly been investigated in skin. Thus, its effects on systemic immunity and extra-cutaneous disease manifestations remain poorly understood.
Marika Catapano, Marta Vergnano, Marco Romano, Satveer K. Mahil, Siew-Eng Choon, A. David Burden, Helen S. Young, Ian M. Carr, Helen J. Lachmann, Giovanna Lombardi, Catherine H. Smith, Francesca D. Ciccarelli, Jonathan N. Barker, Francesca Capon   +13 more
openaire   +8 more sources