Potential Role of IL-37 in Atopic Dermatitis [PDF]
Cells, 2023 Interleukin 37 (IL-37) is a recently discovered member of the IL-1 cytokine family that appears to have anti-inflammatory and immunosuppressive effects in various diseases.
Alicja Mesjasz +3 more
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The role of IL-37 in gastrointestinal diseases [PDF]
Frontiers in ImmunologyGastrointestinal mucosal surface is frequently under challenge due to it’s the large surface area and most common entry of microbes. IL-37, an anti-inflammatory cytokine, regulates local and systemic host immunity. H.
Qiang Wang +5 more
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IL-37/IL-1R8 axis: a novel major mechanism of control at the interface between tumor and immune cells [PDF]
OncoImmunologyInterleukin (IL)-37 is one of the “youngest” IL-1 family members and one of the few molecules exerting anti-inflammatory activity. Upon inflammasome activation, the cytokine precursor is converted into its mature form, which acts intracellularly as a ...
Nadine Landolina +7 more
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The role of IL-37 and IL-38 in rheumatoid arthritis, the potential clinical applications in precision medicine [PDF]
Frontiers in ImmunologyRheumatoid arthritis (RA) is a chronic, autoimmune inflammatory disorder that primarily affects the joints, and in severe cases, can damage other major organs, particularly in susceptible individuals.
Haifeng Zhang +6 more
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The distinct roles of IL-37 and IL-38 in non-small cell lung carcinoma and their clinical implications [PDF]
Frontiers in ImmunologyLung cancer, a significant global health challenge, is primarily classified into non-small cell lung cancer (NSCLC) and small cell lung cancer. Despite advancements in targeted therapies and immunotherapies, NSCLC outcomes remain poor, with low five-year
Jiwei Zhang +4 more
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The Role of IL-37 and IL-38 in Colorectal Cancer [PDF]
Frontiers in Medicine, 2022 Colorectal cancer (CRC) is a major killer. Dysregulation of IL-37 and IL-38, both anti-inflammatory cytokines, is observed in auto-immune diseases.
Jie Dang +8 more
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High-dose IL-37 promotes inflammatory activity of macrophage via Preferential ligation of the IL-18Rα [PDF]
Scientific ReportsInterleukin-37 (IL-37) exists in various human tissues and organs and exhibits extensive anti-inflammatory activity. Recombinant IL-37 ameliorates the insulin resistance and inflammation associated with obesity and type 2 diabetes (T2DM).
Yu Zhang +9 more
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Role of IL-1 Family Cytokines IL-36, IL-37, IL-38 in Osteoarthritis and Rheumatoid Arthritis: A Comprehensive Review [PDF]
Journal of Inflammation ResearchYuan Xu, Jing-Yan Wang, Yang Zou, Xue-Wei Ma, Tian Meng College of Health Industry, Sichuan Tourism University, Chengdu, Sichuan, 610100, People’s Republic of ChinaCorrespondence: Yuan Xu, Email 230973159@qq.comAbstract: Inflammatory cytokines ...
Xu Y, Wang JY, Zou Y, Ma XW, Meng T
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The role of IL-35 and IL-37 in breast cancer – potential therapeutic targets for precision medicine [PDF]
Frontiers in Oncology, 2022 Breast cancer is still a major concern due to its relatively poor prognosis in women, although there are many approaches being developed for the management of breast cancer.
Yuntao Ma +7 more
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The anti-inflammatory cytokine IL-37 improves the NK cell-mediated anti-tumor response [PDF]
OncoImmunologyIL-37 is a member of the IL-1 superfamily exerting anti-inflammatory functions in a number of diseases. Extracellular IL-37 triggers the inhibitory receptor IL-1R8 that is known to regulate different NK cell pathways and functional activities including ...
Nadine Landolina +8 more
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