Results 41 to 50 of about 15,466,885 (336)

Differential Effects of Alarmins on Human and Mouse Basophils

Frontiers in Immunology, 2022
Epithelial-derived alarmins (IL-33, TSLP, and IL-25) play an upstream role in the pathogenesis of asthma. Basophil-derived cytokines are a pivotal component of allergic inflammation.
Adriana R. Gambardella, Adriana R. Gambardella, Remo Poto, Remo Poto, Remo Poto, Remo Poto, Valentina Tirelli, John T. Schroeder, Gianni Marone, Gianni Marone, Gianni Marone, Gianni Marone, Fabrizio Mattei, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Gilda Varricchi, Giovanna Schiavoni   +17 more
doaj   +1 more source

Leishmania promastigotes evade interleukin 12 (IL-12) induction by macrophages and stimulate a broad range of cytokines from CD4+ T cells during initiation of infection. [PDF]

, 1994
Leishmania major are intramacrophage parasites whose eradication requires the induction of T helper 1 (Th1) effector cells capable of activating macrophages to a microbicidal state.
Locksley, RM, Reiner, SL, Stowring, L, Wang, ZE, Zheng, S   +4 more
core   +1 more source

Role of gene polymorphism of IL-4 and IL-17 in recurrent miscarriage, came in art cycles

Репродуктивная эндокринология, 2017
Most researchers suggest that more than 50% of pregnant women after use of assisted reproductive technologies (ART) are faced with the problem of miscarriage, especially in the first trimester.
K. P. Golovatyuk
doaj   +1 more source

Combined therapy with GABA and proinsulin/alum acts synergistically to restore long-term normoglycemia by modulating T-cell autoimmunity and promoting β-cell replication in newly diabetic NOD mice. [PDF]

, 2014
Antigen-based therapies (ABTs) fail to restore normoglycemia in newly diabetic NOD mice, perhaps because too few β-cells remain by the time that ABT-induced regulatory responses arise and spread.
Chen, Zheying, Dang, Hoa, Kaufman, Daniel L, Nguyen, An Viet, Tian, Jide   +4 more
core   +1 more source

The Possible Roles of IL-4/IL-13 in the Development of Eosinophil-Predominant Severe Asthma

Biomolecules
Bronchial asthma is characterized by airway inflammation, airway hyperresponsiveness, and reversible airway obstruction. Eosinophils contribute to the pathogenesis of airway disease mainly by releasing eosinophil-specific granules, lipid mediators ...
Kazuyuki Nakagome, Makoto Nagata
doaj   +1 more source

Single-Chain Soluble Receptor Fusion Proteins as Versatile Cytokine Inhibitors

Frontiers in Immunology, 2020
Cytokines are small secreted proteins that among many functions also play key roles in the orchestration of inflammation in host defense and disease.
Aurora Holgado, Aurora Holgado, Harald Braun, Harald Braun, Kenneth Verstraete, Kenneth Verstraete, Domien Vanneste, Domien Vanneste, Nico Callewaert, Nico Callewaert, Savvas N. Savvides, Savvas N. Savvides, Inna S. Afonina, Inna S. Afonina, Rudi Beyaert, Rudi Beyaert   +15 more
doaj   +1 more source

Natural killer cell stimulatory factor (interleukin 12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells

Journal of Experimental Medicine, 1993
The effects exerted on the in vitro development of antigen-specific T cell lines and T cell clones by addition or neutralization of interleukin 12 (IL-12) in lymphocyte bulk culture were examined.
R. Manetti, P. Parronchi, M. Giudizi, M. Piccinni, E. Maggi, G. Trinchieri, S. Romagnani   +6 more
semanticscholar   +1 more source

Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells

Virulence, 2019
Citrobacter rodentium infection is a murine model for pathogenic intestinal Escherichia coli infection. C. rodentium infection causes an initial decrease in mucus layer thickness, followed by an increase during clearance.
S. Sharba, N. Navabi, M. Padra, J. A. Persson, M. P. Quintana-Hayashi, J. K. Gustafsson, L. Szeponik, V. Venkatakrishnan, Å. Sjöling, S. Nilsson, M. Quiding-Järbrink, M. E. V. Johansson, S. K. Linden   +12 more
doaj   +1 more source

A Quality Improvement Initiative to Standardize Pneumocystis jirovecii Pneumonia Prophylaxis in Pediatric Patients With Solid Tumors

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric patients with extracranial solid tumors (ST) receiving chemotherapy are at an increased risk for Pneumocystis jirovecii pneumonia (PJP). However, evidence guiding prophylaxis practices in this population is limited. A PJP‐related fatality at our institution highlighted inconsistent prescribing approaches and concerns about
Kriti Kumar, Denise M. Connolly, Ellen Kellington, Elyse Zelunka, Karla Kerrigan, Furqan Shaikh, Paul C. Nathan, Meredith S. Irwin, Sarah Cohen‐Gogo   +8 more
wiley   +1 more source

Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis, Okeleji Olayinka, Mariam Z. Quraishi, Lakshmi V. Srivaths, Deborah L. Brown, Neethu M. Menon, Ricardo A. Mosquera, Ashwin P. Patel, James M. Stark, Aravind Yadav   +9 more
wiley   +1 more source