IL-5 and IL-5 receptor in asthma [PDF]
Memorias do Instituto Oswaldo Cruz, 1997 Eosinophils, along with mast cells are key cells involved in the innate immune response against parasitic infection whereas the adaptive immune response is largely dependent on lymphocytes. In chronic parasitic disease and in chronic allergic disease, IL-
ATC Kotsimbos, Q Hamid
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Eosinophils, beyond IL-5 [PDF]
Cells, 2021 New therapeutic monoclonal antibodies targeting the IL-5/IL-5 receptor pathway are extremely efficient in depleting blood eosinophils from subjects with asthma [...]
Stephane Esnault +2 more
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Improving patient outcomes: Mepolizumab’s impact in IL-5-mediated diseases [PDF]
Lung IndiaThe Interleukin-5 (IL-5)-mediated pathogenic role of eosinophils in airway disorders including severe eosinophilic asthma (SEA), chronic rhinosinusitis with nasal polyps (CRSwNP), eosinophilic granulomatosis with polyangiitis (EGPA), and rare hyper ...
Dipti Gothi +5 more
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Anti-IL-5 therapies for asthma [PDF]
Cochrane Database of Systematic Reviews, 2022 This is the second update of previously published reviews in the Cochrane Library (2015, first update 2017). Interleukin-5 (IL-5) is the main cytokine involved in the proliferation, maturation, activation and survival of eosinophils, which cause airway inflammation and are a classic feature of asthma.
Farne, Hugo A +5 more
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The role of interleukin-5 (IL-5 ) in vivo: studies with IL-5 deficient mice [PDF]
Memorias do Instituto Oswaldo Cruz, 1997 Eosinophil recruitment is a characteristic feature of a number of pathological conditions and was the topic of the recent International Symposium on allergic inflammation, asthma, parasitic and infectious diseases (Rio de Janeiro, June 3-5, 1996).
Klaus I Matthaei +2 more
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IL-5 signaling in asthmatic derived fibroblasts exacerbates airway remodeling through ECM dysregulation and apoptosis resistance [PDF]
Respiratory ResearchBackground Airway remodelling, a critical feature of severe asthma, involves fibroblast-driven extracellular matrix (ECM) dysregulation. While IL-5 is pivotal in eosinophilic inflammation, its direct role in fibroblast-mediated fibrosis remains undefined.
Rola Abujabal +10 more
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German Asthma Net: Characterisation of responders to anti-IL-5 and anti-IL-5(R) therapy
PulmonologyIntroduction Previous studies of anti-IL-5/IL-5(R) therapies in severe asthma found that response was mainly predicted by indicators of good baseline disease control.
Christina Bal +14 more
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Interleukin-5, Interleukin-6 and Eosinophils in COVID-19 Egyptian Patients: Potential Clues for Prognosis and Immunotherapy [PDF]
International Journal of Medical Arts, 2022 Background: A decrease in eosinophil levels was found in Corona Virus Disease-19 [COVID-19] patients [eosinopenia]. However, recent research on eosinopenia and disease severity has yielded conflicting results.Objectives: To investigate the relationship ...
Sara Taha +6 more
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Pollinosis in children and adolescents: modern aspects of pathogenesis and tendencies in therapy
Аллергология и Иммунология в Педиатрии, 2023 The development of pollinosis in children and adolescents is determined by the influence of genetic and environmental factors. The pathogenetic basis of pollinosis in children and adolescents is the differentiation of Th0 to Th2, activation of Th2cells ...
I. I. Balabolkin
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Evaluation of Serum IL-33, IL-5 and Trace Elements Levels among Asthmatic Patients
Journal of Pure and Applied Microbiology, 2022 The precise relationship between interleukins-33 and IL-5, as well as some trace elements and asthma, is unknown. The target of research was to compare and link the above-mentioned serological parameters in asthmatic patients and healthy controls.
Mayada Noori Iqbal +3 more
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