Results 11 to 20 of about 1,863,297 (279)

Activation of the STAT3/Acute Phase Response Factor Transcription Factor by Interleukin-5 [PDF]

, 1995
The receptor for interleukin-5 (IL-5R) is composed of a unique a chain (IL-5Ra) expressed on eosinophils and basophils, associated with a bc subunit, which is shared by the receptors for IL-3 and granulocyte macrophagecolony stimulating factor.
Caldenhoven, Eric, Dijk, Thamar B. van, Groot, Rolf P. de, Koenderman, L., Lammers, J.W.J., Raaijmakers, J.A.M.   +5 more
core   +14 more sources

Study of immunological parameters associated with asthma with and without bacterial infection in Thi-Qar Province [PDF]

Romanian Journal of Medical Practice
Background. Asthma is a prevalent and persistent respiratory condition that impacts more than 300 million individuals globally, leading to substantial illness and death. Objective.
Huda Kareem ABBAS, Huda Kareem ABBAS
doaj   +1 more source

Anti–IL-5 (mepolizumab) therapy reduces eosinophil activation ex vivo and increases IL-5 and IL-5 receptor levels [PDF]

Journal of Allergy and Clinical Immunology, 2008
Anti-IL-5 might be a useful therapeutic agent for eosinophilic disorders, yet its immunologic consequences have not been well characterized.We sought to characterize the hematologic and immunologic effects of anti-IL-5 in human subjects.The effects of 3-month infusions of mepolizumab were assessed in 25 patients with a variety of eosinophilic syndromes.
Miguel L, Stein, Joyce M, Villanueva, Bridget K, Buckmeier, Yoshiyuki, Yamada, Alexandra H, Filipovich, Amal H, Assa'ad, Marc E, Rothenberg   +6 more
openaire   +2 more sources

Cooperation between interleukin-5 and the chemokine eotaxin to induce eosinophil accumulation in vivo. [PDF]

, 1995
Experiments were designed to study the effect of systemically administered IL-5 on local eosinophil accumulation induced by the intradermal injection of the chemokine eotaxin in the guinea pig.
Collins, PD, Griffiths-Johnson, DA, Jose, PJ, Marleau, S, Williams, TJ   +4 more
core   +2 more sources

Dietary supplementation with fructooligosaccharides ameliorates allergy development following DEHP exposure in mice

Food and Agricultural Immunology, 2021
Fructooligosaccharides (FOS), a prebiotic supplement, can enhance immunological responses, probably through regulation of gastrointestinal microflora. On the other hand, some environmental pollutants have adjuvanticity against allergic reactions/diseases.
Akiko Yasuda, Ken-ichiro Inoue, Chiaki Sanbongi, Wakako Suzuki, Hirohisa Takano   +4 more
doaj   +1 more source

MicroRNA regulation of type 2 innate lymphoid cell homeostasis and function in allergic inflammation. [PDF]

, 2017
MicroRNAs (miRNAs) exert powerful effects on immunity through coordinate regulation of multiple target genes in a wide variety of cells. Type 2 innate lymphoid cells (ILC2s) are tissue sentinel mediators of allergic inflammation.
Ansel, K Mark, Baumjohann, Dirk, Happ, Hannah C, Locksley, Richard M, Pua, Heather H, Schneider, Christoph, Singh, Priti B, von Moltke, Jakob   +7 more
core   +2 more sources

Natural variation in immune responses to neonatal mycobacterium bovis bacillus calmette-guerin (BCG) vaccination in a cohort of Gambian infants [PDF]

, 2008
Background There is a need for new vaccines for tuberculosis (TB) that protect against adult pulmonary disease in regions where BCG is not effective.
A Lalvani, A Marchant, AM Cooper, AP Soares, Arnaud Marchant, AS Pym, AV Hill, B Wu, Ben Marais, Chris Finan, D Elias, D O'Donovan, E Jouanguy, G Dai, G Sirugo, GA Colditz, GA Poland, GF Black, GF Black, H Fletcher, H Mahomed, I Malhotra, J Vekemans, JJ Ellner, LB Reichman, LC Rodrigues, M Bonecini-Almeida, M Ota, MA Behr, MA Horwitz, Martin O. C. Ota, Melanie J. Newport, MJ Newport, MJ Newport, MOC Ota, NE Beveridge, PC Hill, PEM Fine, RE Weir, RE Weir, RH Brookes, S Dupuis, S Mallal, SE Dorman, ST Bennett, TB Stop, V Davids   +46 more
core   +3 more sources

The Role of Eosinophil-Derived Neurotoxin and Vascular Endothelial Growth Factor in the Pathogenesis of Eosinophilic Asthma

Cells, 2023
Asthma is a chronic complex pulmonary disease characterized by airway inflammation, remodeling, and hyperresponsiveness. Vascular endothelial growth factor (VEGF) and eosinophil-derived neurotoxin (EDN) are two significant mediators involved in the ...
Maciej Tota, Julia Łacwik, Julia Laska, Łukasz Sędek, Krzysztof Gomułka   +4 more
doaj   +1 more source

Bifidobacterium longum and Lactobacillus plantarum alleviate house dust mite allergen-induced allergic rhinitis by regulating IL-4, IL-5, and IL-10 expression

Food and Agricultural Immunology, 2019
We examined the effects of Bifidobacterium longum IM55, Lactobacillus plantarum IM76, and their (1:1 and 1:9) mixtures (PMs) on house dust mite allergen extract (HDMA)-induced allergic rhinitis (AR) in mice.
Jeon-Kyung Kim, Jae-Young Kim, Hye In Kim, Myung Joo Han, Dong-Hyun Kim   +4 more
doaj   +1 more source

Enrichment of innate lymphoid cell populations in gingival tissue [PDF]

, 2018
Innate lymphoid cells (ILCs) are a population of lymphocytes that act as the first line of immunologic defense at mucosal surfaces. The ILC family in the skin, lungs, and gastrointestinal tissues has been investigated, and there are reports of individual
Adrados Planell, A., Brown, J.L., Butcher, J.P., Campbell, L., Culshaw, S., Malcolm, J.   +5 more
core   +2 more sources