Results 251 to 260 of about 1,863,297 (279)
Some of the next articles are maybe not open access.
Delineation of IL-5 domains predicted to engage the IL-5 receptor complex
The Journal of Immunology, 1996Abstract IL-5 is an interdigitating homodimeric glycoprotein and a member of the helical bundle family of cytokines. IL-5 is a potent activator of eosinophils and a specific promoter of their differentiation. This activity has implicated IL-5 in the pathogenesis of asthma and allergic disease.
R R, Dickason, M M, Huston, D P, Huston
openaire +2 more sources
Development of IL-5 Receptor Antagonists
Current Pharmaceutical Design, 2002A wealth of both clinical and pre-clinical data has strongly implicated the eosinophil in the pathogenesis of asthma, highlighting this cell type as a potential target for novel anti-inflammatory approaches to asthma therapy. The Th2 lymphocyte derived cytokine Interleukin-5 (IL-5) has emerged as the key regulator of eosinophil production, thus ...
Iain, Uings, Murray, McKinnon
openaire +2 more sources
Anti-IL-5 and hypereosinophilic syndromes
Clinical Immunology, 2005Hypereosinophilic syndromes represent a heterogeneous group of disorders characterized by peripheral eosinophilia and end-organ damage associated with eosinophil infiltrations. In many instances, the eosinophilia is refractory to standard therapies and clinicians rely on potentially toxic alternatives.
Steven A, Sutton +2 more
openaire +2 more sources
IL‐5 and IL‐5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans
Allergy, 2007Background: Eosinophils are recruited into the affected tissue of asthma and atopic dermatitis (AD) patients. IL‐5 and IL‐5R are highly expressed in the AD skin lesions, yet the reported levels of IL‐8 are controversial.Method: We genotyped 17 singlenucleotide polymorphisms (SNPs) from five genes of the 1120 case‐control samples (646 AD and 474 ...
J-H, Namkung +7 more
openaire +2 more sources
2016
Because of the central role played by interleukin-5 (IL-5) in maturation, activation, proliferation and survival of eosinophils, this cytokine is a key target for treatment of eosinophilic asthma [1–4]. In this regard it is noteworthy that, among the pleiotropic effects of corticosteroids, inhibition of IL-5 synthesis is one of the most important ...
Pelaia, Girolamo +2 more
openaire +1 more source
Because of the central role played by interleukin-5 (IL-5) in maturation, activation, proliferation and survival of eosinophils, this cytokine is a key target for treatment of eosinophilic asthma [1–4]. In this regard it is noteworthy that, among the pleiotropic effects of corticosteroids, inhibition of IL-5 synthesis is one of the most important ...
Pelaia, Girolamo +2 more
openaire +1 more source
1995
Abstract The cDNA sequence for human and mouse (GenBank accession numbers X04688 and X06270) predict proteins of 134 and 133 amino acids, respectively. Sequence information is available for both the human and mouse genomic genes (GenBank accession numbers J02971 and XO6271).The coding sequence of the IL-5 gene forms four exons.
openaire +1 more source
Abstract The cDNA sequence for human and mouse (GenBank accession numbers X04688 and X06270) predict proteins of 134 and 133 amino acids, respectively. Sequence information is available for both the human and mouse genomic genes (GenBank accession numbers J02971 and XO6271).The coding sequence of the IL-5 gene forms four exons.
openaire +1 more source
Regulation of IL-5 expression.
Archivum immunologiae et therapiae experimentalis, 2002Interleukin 5 (IL-5) is a cytokine primarily involved in the pathogenesis of atopic diseases. It specifically controls the production, activation and localization of eosinophils, the major cause of tissue damage in atopic diseases. IL-5 belongs to a gene family shared by IL-3, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF) and is ...
V A, Mordvinov, C J, Sanderson
openaire +1 more source