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Biology of IL-5 in health and disease
Annals of Allergy, Asthma & Immunology, 1999Reading this article will increase the readers' knowledge of the biology of interleukin-5 (IL-5), an important cytokine. The immune and inflammatory responses of any organism are the basis of the defense mechanism ensuring its survival. The role of IL-5 in these processes, as well as in the pathogenesis of various diseases has been discussed along with
T, Lalani, R K, Simmons, A R, Ahmed
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Development of IL-5 Receptor Antagonists
Current Pharmaceutical Design, 2002A wealth of both clinical and pre-clinical data has strongly implicated the eosinophil in the pathogenesis of asthma, highlighting this cell type as a potential target for novel anti-inflammatory approaches to asthma therapy. The Th2 lymphocyte derived cytokine Interleukin-5 (IL-5) has emerged as the key regulator of eosinophil production, thus ...
Iain, Uings, Murray, McKinnon
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Regulation of IL-5 expression.
Archivum immunologiae et therapiae experimentalis, 2002Interleukin 5 (IL-5) is a cytokine primarily involved in the pathogenesis of atopic diseases. It specifically controls the production, activation and localization of eosinophils, the major cause of tissue damage in atopic diseases. IL-5 belongs to a gene family shared by IL-3, IL-4 and granulocyte-macrophage colony-stimulating factor (GM-CSF) and is ...
V A, Mordvinov, C J, Sanderson
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Sputum IL-5 predicts the response to anti-IL-5/IL-5R therapy
Revue des Maladies Respiratoires, 2023C. Moermans +9 more
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1995
Abstract The cDNA sequence for human and mouse (GenBank accession numbers X04688 and X06270) predict proteins of 134 and 133 amino acids, respectively. Sequence information is available for both the human and mouse genomic genes (GenBank accession numbers J02971 and XO6271).The coding sequence of the IL-5 gene forms four exons.
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Abstract The cDNA sequence for human and mouse (GenBank accession numbers X04688 and X06270) predict proteins of 134 and 133 amino acids, respectively. Sequence information is available for both the human and mouse genomic genes (GenBank accession numbers J02971 and XO6271).The coding sequence of the IL-5 gene forms four exons.
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