Results 251 to 260 of about 1,904,009 (281)
Some of the next articles are maybe not open access.
Delineation of IL-5 domains predicted to engage the IL-5 receptor complex
The Journal of Immunology, 1996Abstract IL-5 is an interdigitating homodimeric glycoprotein and a member of the helical bundle family of cytokines. IL-5 is a potent activator of eosinophils and a specific promoter of their differentiation. This activity has implicated IL-5 in the pathogenesis of asthma and allergic disease.
R R, Dickason, M M, Huston, D P, Huston
openaire +2 more sources
Regulation of IL–5 and IL–5 Receptor Expression in the Bone Marrow of Allergic Asthmatics
International Archives of Allergy and Immunology, 1999<b>Background: </b>Following consistent demonstrations of the clinical relevance of fluctuations in eosinophil–basophil (Eo–B) progenitors in the blood of patients with a variety of allergic airway disorders, we have turned our attention recently to hemopoietic events occurring in the bone marrow of allergic asthmatic subjects, utilizing a ...
Denburg, Judah A. +5 more
openaire +3 more sources
The Journal of Immunology, 1990
Abstract IL-5 is a T cell-derived lymphokine that induces B cell growth and differentiation in murine systems. In this study, we examined the role of carbohydrate moiety of IL-5 in the expression of biological function. IL-5 polypeptides translated in Xenopus oocytes were heterogeneous in terms of isoelectric point (pI 4.7 to 8.0) and m ...
A, Tominaga +7 more
openaire +2 more sources
Abstract IL-5 is a T cell-derived lymphokine that induces B cell growth and differentiation in murine systems. In this study, we examined the role of carbohydrate moiety of IL-5 in the expression of biological function. IL-5 polypeptides translated in Xenopus oocytes were heterogeneous in terms of isoelectric point (pI 4.7 to 8.0) and m ...
A, Tominaga +7 more
openaire +2 more sources
Effect of Anti-IL-5 and IL-5 on Airway Hyperreactivity and Eosinophils in Guinea Pigs
American Review of Respiratory Disease, 1993Abstract Chronic ovalbumin challenge of sensitized guinea pigs induces bronchoalveolar lavage (BAL) eosinophilia, neutrophilia, and tracheal hyperreactivity. In the present study, the influence of monoclonal antibody to murine interleukin-5 (anti-IL-5) on these phenomena is examined.
A J, Van Oosterhout +5 more
openaire +2 more sources
IL‐5 and IL‐5 receptor alpha polymorphisms are associated with atopic dermatitis in Koreans
Allergy, 2007Background: Eosinophils are recruited into the affected tissue of asthma and atopic dermatitis (AD) patients. IL‐5 and IL‐5R are highly expressed in the AD skin lesions, yet the reported levels of IL‐8 are controversial.Method: We genotyped 17 singlenucleotide polymorphisms (SNPs) from five genes of the 1120 case‐control samples (646 AD and 474 ...
J-H, Namkung +7 more
openaire +2 more sources
Development of IL-5 Receptor Antagonists
Current Pharmaceutical Design, 2002A wealth of both clinical and pre-clinical data has strongly implicated the eosinophil in the pathogenesis of asthma, highlighting this cell type as a potential target for novel anti-inflammatory approaches to asthma therapy. The Th2 lymphocyte derived cytokine Interleukin-5 (IL-5) has emerged as the key regulator of eosinophil production, thus ...
Iain, Uings, Murray, McKinnon
openaire +2 more sources
The mechanism of IL-5 signal transduction
American Journal of Physiology-Cell Physiology, 1998Cytokines are important regulators of hematopoiesis. They exert their actions by binding to specific receptors on the cell surface. Interleukin-5 (IL-5) is a critical cytokine that regulates the growth, activation, and survival of eosinophils. Because eosinophils play a seminal role in the pathogenesis of asthma and allergic diseases, an understanding
T, Adachi, R, Alam
openaire +2 more sources
Biology of IL-5 in health and disease
Annals of Allergy, Asthma & Immunology, 1999Reading this article will increase the readers' knowledge of the biology of interleukin-5 (IL-5), an important cytokine. The immune and inflammatory responses of any organism are the basis of the defense mechanism ensuring its survival. The role of IL-5 in these processes, as well as in the pathogenesis of various diseases has been discussed along with
T, Lalani, R K, Simmons, A R, Ahmed
openaire +2 more sources
Anti-IL-5 and hypereosinophilic syndromes
Clinical Immunology, 2005Hypereosinophilic syndromes represent a heterogeneous group of disorders characterized by peripheral eosinophilia and end-organ damage associated with eosinophil infiltrations. In many instances, the eosinophilia is refractory to standard therapies and clinicians rely on potentially toxic alternatives.
Steven A, Sutton +2 more
openaire +2 more sources
2016
Because of the central role played by interleukin-5 (IL-5) in maturation, activation, proliferation and survival of eosinophils, this cytokine is a key target for treatment of eosinophilic asthma [1–4]. In this regard it is noteworthy that, among the pleiotropic effects of corticosteroids, inhibition of IL-5 synthesis is one of the most important ...
Pelaia, Girolamo +2 more
openaire +1 more source
Because of the central role played by interleukin-5 (IL-5) in maturation, activation, proliferation and survival of eosinophils, this cytokine is a key target for treatment of eosinophilic asthma [1–4]. In this regard it is noteworthy that, among the pleiotropic effects of corticosteroids, inhibition of IL-5 synthesis is one of the most important ...
Pelaia, Girolamo +2 more
openaire +1 more source