Results 41 to 50 of about 13,521,848 (335)
Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling [PDF]
Journal of Biological Chemistry, 2013 Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) is coordinated by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-signaling, respectively. The soluble IL-6R is mainly generated by ADAM10- and ADAM17-mediated ectodomain shedding.
Paul, Baran +4 more
openaire +2 more sources
Translating IL-6 biology into effective treatments
Nature Reviews Rheumatology, 2020 In 1973, IL-6 was identified as a soluble factor that is secreted by T cells and is important for antibody production by B cells. Since its discovery more than 40 years ago, the IL-6 pathway has emerged as a pivotal pathway involved in immune regulation ...
E. Choy +5 more
semanticscholar +1 more source
Repopulating Microglia Promote Brain Repair in an IL-6-Dependent Manner.
Cell, 2020 Cognitive dysfunction and reactive microglia are hallmarks of traumatic brain injury (TBI), yet whether these cells contribute to cognitive deficits and secondary inflammatory pathology remains poorly understood.
Emily F. Willis +12 more
semanticscholar +1 more source
Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α [PDF]
Avicenna Journal of PhytomedicineObjective: Carvacrol has anti-inflammatory effects. According to the links between inflammatory processes and seizures, this study was designed to investigate the potential effect of carvacrol in reducing seizure severity and involvement of hippocampal ...
Hesamodin Bagheripoor +2 more
doaj +1 more source
Heliyon, 2022 Interleukins are assumed to be closely related to the occurrence and development of human malignant tumors, while a few of them were commonly used as diagnostic markers in clinical cancer, including lung cancer.
Xi Yan +5 more
doaj +1 more source
Genetic partitioning of interleukin-6 signalling in mice dissociates Stat3 from Smad3-mediated lung fibrosis [PDF]
, 2012 Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis.
Anderson, G.P. +19 more
core +2 more sources
The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing
Biomedicines, 2020 The timely resolution of wound healing is critical for restoring the skin as a protective barrier. The switch from a proinflammatory to a reparative microenvironment must be tightly regulated. Interleukin (IL)-6 is a key modulator of the inflammatory and
B. Z. Johnson +4 more
semanticscholar +1 more source
Frontiers in Immunology, 2017 Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis.
Fabrine Sales Massafera Tristão +6 more
doaj +1 more source
Interleukin 6 plays a role in the migration of magnetically levitated mesenchymal stem cells spheroids [PDF]
, 2018 Mesenchymal stem cells (MSCs) reside quiescently within a specialised ‘niche’ environment in the bone marrow. However, following appropriate signalling cues, MSCs mobilise and migrate out from the niche, typically toward either sites of injury (a ...
Berry, Catherine Cecilia +4 more
core +2 more sources
IL-6 and diabetic kidney disease
Frontiers in ImmunologyDiabetic kidney disease (DKD) is a severe microvascular complication of diabetes associated with high mortality and disability rates. Inflammation has emerged as a key pathological mechanism in DKD, prompting interest in novel therapeutic approaches ...
Lei Zhang, Futian Xu, Liyan Hou
doaj +1 more source