Minimal Interleukin 6 (IL-6) Receptor Stalk Composition for IL-6 Receptor Shedding and IL-6 Classic Signaling [PDF]
Journal of Biological Chemistry, 2013 Signaling of the pleiotropic cytokine Interleukin-6 (IL-6) is coordinated by membrane-bound and soluble forms of the IL-6 receptor (IL-6R) in processes called classic and trans-signaling, respectively. The soluble IL-6R is mainly generated by ADAM10- and ADAM17-mediated ectodomain shedding.
Paul, Baran +4 more
openaire +2 more sources
Phenotypic and Functional Heterogeneity of Low-Density and High-Density Human Lung Macrophages
Biomedicines, 2021 Background: Pulmonary macrophages are a highly heterogeneous cell population distributed in different lung compartments. Methods: We separated two subpopulations of macrophages from human lung parenchyma according to flotation over density gradients ...
Barbara Balestrieri +8 more
doaj +1 more source
Trust as a mediator in the relationship between childhood sexual abuse and IL-6 level in adulthood [PDF]
, 2020 Childhood sexual abuse (CSA) has been shown to predict the coupling of depression and inflammation in adulthood. Trust within intimate relationships, a core element in marital relations, has been shown to predict positive physical and mental health ...
Chan, Cecilia L. W. +14 more
core +1 more source
Relationship between levels of inflammatory cytokines in the genital tract and CD4+ cell counts in women with acute HIV-1 infection. [PDF]
, 2008 Inflammatory responses at mucosal surfaces after human immunodeficiency virus type 1 (HIV-1) transmission may influence disease outcome. We evaluated levels of interleukin (IL)-1beta, IL-6, tumor necrosis factor-alpha, IL-8, IL-10, and IL-12 in genital ...
Bebell, Lisa M +7 more
core +1 more source
Carvacrol alleviates the proconvulsive effects of lipopolysaccharide (LPS) and reduces the gene expression of proinflammatory cytokines interleukin-1 and tumor necrosis factor-α [PDF]
Avicenna Journal of PhytomedicineObjective: Carvacrol has anti-inflammatory effects. According to the links between inflammatory processes and seizures, this study was designed to investigate the potential effect of carvacrol in reducing seizure severity and involvement of hippocampal ...
Hesamodin Bagheripoor +2 more
doaj +1 more source
Heliyon, 2022 Interleukins are assumed to be closely related to the occurrence and development of human malignant tumors, while a few of them were commonly used as diagnostic markers in clinical cancer, including lung cancer.
Xi Yan +5 more
doaj +1 more source
High blood levels of IL-6 nicely correlate with animal survival in trained C26 bearing mice [PDF]
, 2015 Exercise is a beneficial adjunct therapy to maintain or enhance quality of life in cancer patients. Recently, few studies demonstrated a correlation between high concentrations of IL-6 and a poor survival.
Adamo, Sergio +9 more
core +2 more sources
Decitabine, a DNA-demethylating agent, promotes differentiation via NOTCH1 signaling and alters immune-related pathways in muscle-invasive bladder cancer [PDF]
, 2017 Aberrant DNA methylation observed in cancer can provide survival benefits to cells by silencing genes essential for anti-tumor activity. DNA-demethylating agents such as Decitabine (DAC)/Azacitidine (AZA) activate otherwise silenced tumor suppressor ...
Attwood, Kristopher +16 more
core +3 more sources
Frontiers in Immunology, 2017 Paracoccidioidomycosis (PCM), a chronic granulomatous disease caused by the thermally dimorphic fungus Paracoccidioides brasiliensis and Paracoccidioides lutzii, has the highest mortality rate among systemic mycosis.
Fabrine Sales Massafera Tristão +6 more
doaj +1 more source
IL-6 and diabetic kidney disease
Frontiers in ImmunologyDiabetic kidney disease (DKD) is a severe microvascular complication of diabetes associated with high mortality and disability rates. Inflammation has emerged as a key pathological mechanism in DKD, prompting interest in novel therapeutic approaches ...
Lei Zhang, Futian Xu, Liyan Hou
doaj +1 more source