Results 11 to 20 of about 81,893,885 (284)
Journal of Inflammation Research, 2021 Joanna Kamińska,1 Violetta Dymicka-Piekarska,1 Robert Chrzanowski,2 Karol Sawicki,2 Anna J Milewska,3 Justyna Zińczuk,1 Marzena Tylicka,4 Marek Jadeszko,2 Zenon Mariak,2 Ewa M Kratz,5 Joanna Matowicka-Karna,1 Johannes Kornhuber,6 Piotr ...
Kamińska J +13 more
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IL-6 Trans-Signaling via the Soluble IL-6 Receptor: Importance for the Pro-Inflammatory Activities of IL-6 [PDF]
International Journal of Biological Sciences, 2012 Interleukin-6 (IL-6) is a cytokine with many activities. It has functions in the regulation of the immune system and the nervous system. Furthermore, IL-6 is involved in liver regeneration and in the metabolic control of the body.
Stefan Rose-John
doaj +3 more sources
The role of IL-6 and IL-6 blockade in COVID-19 [PDF]
Expert Review of Clinical Immunology, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) induces a dysregulated hyperinflammatory response.Authors review evidence on IL-6 and IL-6 blockade in coronavirus disease 2019 (COVID-19) and discuss the pathophysiological and prognostic roles of this cytokine and the clinical impact of pharmacological blockade of IL-6 .
Nicola Potere +7 more
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The effects of anti-IL-6 therapy in advanced ovarian cancer [PDF]
, 2010 PhDIL-6 is a pleiotropic cytokine that has a significant role in inflammatory processes. In relation to ovarian cancer biology there is emerging evidence that it mediates processes relating to tumour growth, invasion, angiogenesis and chemo-resistance ...
Coward, Jermaine
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Immunity, Inflammation and Disease, 2020 Introduction The aim of this study was to give quantitative insight into the number of cytokine molecules needed to activate a target cell and relate this to the physiological consequences of the amounts of cytokines typically detectable in humans.
Morten B. Hansen
doaj +1 more source
The immune and metabolic treatment approach of using testosterone on mice models of liver injury
Frontiers in Pharmacology, 2023 Background: Natural killer (NK) cells showed an anti-fibrotic effect; however, their function is thought to be impaired in advanced liver injury. In the current study, we aimed to assess the immune and metabolic impact of testosterone on mice models of ...
Johnny Amer +3 more
doaj +1 more source
IL-6 controls susceptibility to helminth infection by impeding Th2 responsiveness and altering the Treg phenotype in vivo [PDF]
, 2014 IL-6 plays a pivotal role in favoring T-cell commitment toward a Th17 cell rather than Treg-cell phenotype, as established through in vitro model systems.
Maizels, Rick M. +5 more
core +1 more source
Immunological studies of chronic ocular toxoplasmosis : up-regulation of major histocompatibility complex class I and transforming growth factor beta and a protective role for interleukin-6 [PDF]
, 2001 A murine model was used to characterize the local immune and inflammatory response during ocular toxoplasmosis. Major histocompatibility complex (MHC) class I, normally expressed at low levels in immune-privileged sites such as the eye, was up-regulated ...
Byrne, N. +6 more
core +3 more sources
Molecules, 2021 The contemporary theory of the inflammatory-immunological pathomechanism of atherosclerosis includes the participation of interleukin-1β (Il), Il-6, Il-10, Il-12, RANTES, and homocysteine in this process.
Magdalena Borowska +5 more
doaj +1 more source
Interleukin-6 (IL-6) Production by Astrocytes: Autocrine Regulation by IL-6 and the Soluble IL-6 Receptor [PDF]
The Journal of Neuroscience, 1999 In the CNS, astrocytes are a major inducible source of interleukin-6 (IL-6). Although IL-6 has beneficial effects in the CNS because of its neurotrophic properties, its overexpression is generally detrimental, adding to the pathophysiology associated with CNS disorders.
N J, Van Wagoner +3 more
openaire +2 more sources