Results 61 to 70 of about 13,521,848 (335)

Correlation of Early Outcomes and Intradiscal Interleukin-6 Expression in Lumbar Fusion Patients. [PDF]

, 2020
OBJECTIVE: To determine if there is correlation between intradiscal levels of interleukin-6 (IL-6) and early outcome measures in patients undergoing lumbar fusion for painful disc degeneration.
Anderson, D Greg, Antonacci, Christopher L, Kepler, Chris K, Koerner, John D, Markova, Dessislava Z, Mendelis, Joseph, Schroeder, Greg D, Vaccaro, Alexander R   +7 more
core   +1 more source

HIV induces expression of complement component C3 in astrocytes by NF-κB-dependent activation of interleukin-6 synthesis [PDF]

, 2017
Background Abnormal activation of the complement system contributes to some central nervous system diseases but the role of complement in HIV-associated neurocognitive disorder (HAND) is unclear.
Borjabad, Alejandra, Chao, Wei, Emdad, Luni, Fisher, Paul B., Morgello, Susan, Murray, Jacinta, Nitkiewicz, Jadwiga, Potash, Mary Jane, Volsky, David J.   +8 more
core   +2 more sources

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source

IL-6 trans-signaling induces plasminogen activator inhibitor-1 from vascular endothelial cells in cytokine release syndrome

Proceedings of the National Academy of Sciences of the United States of America, 2020
Significance Cytokine release syndrome (CRS) is a life-threatening complication induced by hyperinflammatory responses. However, no specific immunotherapies are available for its treatment.
Sujin Kang, Toshio Tanaka, H. Inoue, C. Ono, S. Hashimoto, Y. Kioi, Hisatake Matsumoto, H. Matsuura, Tsunehiro Matsubara, Kentarou Shimizu, H. Ogura, Y. Matsuura, T. Kishimoto   +12 more
semanticscholar   +1 more source

Environmental Circadian Disruption Elevates the IL-6 Response to Lipopolysaccharide in Blood [PDF]

, 2013
The immune system is regulated by circadian clocks within the brain and immune cells. Environmental circadian disruption (ECD), consisting of a 6-h phase advance of the light:dark cycle once a week for 4 weeks, elevates the inflammatory response to ...
Adams, Kandis L., Castanon-Cervantes, Oscar, Davidson, Alec J., Evans, Jennifer A.   +3 more
core   +2 more sources

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Producción de citoquinas proinflamatorias durante los estadios tempranos de la infección experimental por Paracoccidioides brasiliensis

Iatreia, 2001
La paracoccidioidomicosis (PCM) es una micosis sistémica restringida a América Latina y producida por la inhalación de las conidias del hongo dimórfico Paracoccidioides brasilienis (Pb) (1).
Luz Elena Cano, Angela Restrepo, Blanca Ortiz, Jorge Sahaza, Angel González   +4 more
doaj  

Correlation Between Interleukin IL-6/IL-6 Receptor Polymorphisms (IL6–174C>G and IL6R 1073A>C) and RAS/BRAF Mutations in Patients with Colorectal Cancer

Gastroenterology Insights
Background: Chronic inflammation is an important factor in the development and progression of colorectal cancer (CRC). One of the key participants of chronic inflammation is interleukin-6 (IL-6), which enhances tumor malignancy.
Ekaterina Smagina, Dar’ya Polit’ko, Vadim Kumeiko, Lyudmila Gurina, Anna Stenkova   +4 more
doaj   +1 more source

The Role of gp130 Cytokines in Tuberculosis

Cells, 2020
Protective immune responses to Mycobacterium tuberculosis (Mtb) infection substantially depend on a delicate balance within cytokine networks. Thus, immunosuppressive therapy by cytokine blockers, as successfully used in the management of various chronic
Kristina Ritter, Jasmin Rousseau, Christoph Hölscher   +2 more
doaj   +1 more source

IL-6: Relevance for immunopathology of SARS-CoV-2

Cytokine & growth factor reviews, 2020
Highlights • COVID-19 severe outcomes is associated with the respiratory failure and cytokine release syndrome with elevated IL-6 as a predicting parameter.• Chronic inflammation, associated with elevated inflammatory serum cytokines, including IL-6, may
E. Gubernatorova, E. Gubernatorova, E. Gorshkova, A. Polinova, M. Drutskaya   +4 more
semanticscholar   +1 more source