Results 41 to 50 of about 1,880,528 (243)

The Effect of Heparin and Other Exogenous Glycosaminoglycans (GAGs) in Reducing IL-1β-Induced Pro-Inflammatory Cytokine IL-8 and IL-6 mRNA Expression and the Potential Role for Reducing Inflammation

Pharmaceuticals
Glycosaminoglycans (GAGs) are long linear polysaccharides found in every mammalian tissue. Previously thought only to be involved in cellular structure or hydration, GAGs are now known to be involved in cell signaling and protein modulation in cellular ...
Murtaza Jafri, Lin Li, Binhua Liang, Ma Luo   +3 more
doaj   +1 more source

Clinical value of blood markers to assess the severity of coronavirus disease 2019

BMC Infectious Diseases, 2021
Background Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) is threatening the world with the symptoms of seasonal influenza. This study was conducted to investigate the patient characteristics and clinical value of blood markers to ...
Liu-Niu Xiao, Xiao Ran, Yan-Xia Zhong, Shu-Sheng Li   +3 more
doaj   +1 more source

Genetic variation of TLR4 influences immunoendocrine stress response: an observational study in cardiac surgical patients [PDF]

, 2011
Introduction: Systemic inflammation (e.g. following surgery) involves Toll-like receptor (TLR) signaling and leads to an endocrine stress response. This study aims to investigate a possible influence of TLR2 and TLR4 single nucleotide polymorphisms (SNPs)
Koch, Alexander, Hamann, Lutz, Schott, Matthias, Boehm, Olaf, Grotemeyer, Dirk, Kurt, Muhammed, Schwenke, Carsten, Schumann, Ralf R., Bornstein, Stefan R., Zacharowski, Kai   +9 more
core   +1 more source

Real‐World Pediatric Blinatumomab Administration: Access to Outpatient Care Delivery and Impact of a Hospital‐Dispensed Model

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Blinatumomab has been shown to be highly effective for patients with pediatric B‐ALL and has recently become standard of care therapy. Due to its past use in the clinical trial setting, there is limited information available about real‐world administration.
Katelyn Oranges, Kelly A. Duffy, Sara McDonough, Evelyn Kurpiewski, R. Jennifer Randall, Allison Barz Leahy, Haley M. Newman, Joyce P. Lee, Stephen P. Hunger, Anne F. Reilly, David T. Teachey, Susan R. Rheingold, Daniel J. Zheng   +12 more
wiley   +1 more source

Study regarding the use of salivary 8-hydroxideoxyguanosine and Interleukin-1 gene polymorphism - as potential biomarkers in the diagnosis of aggressive periodontitis

Romanian Journal of Laboratory Medicine, 2013
Scopul acestui studiu este de a explora posibilitatea de a folosi 8-hidroxideoxiguanozina salivara (8-OHdG) şi polimorfismul genei interleukinei-1 (IL-1) salivare în diagnosticul pacienţilor cu boală parodontală agresivă.
Badea Victoria, Grigorian Mircea, Nucă Cristina, Amariei Comeliu, Martinescu Alina, Voineagu Lavinia   +5 more
doaj   +1 more source

Endothelial preconditioning by transient oxidative stress reduces inflammatory responses of cultured endothelial cells to TNF-α [PDF]

, 2000
Brief episodes of ischemia can render an organ resistant to subsequent severe ischemia. This ‘ischemic preconditioning’ is ascribed to various mechanisms, including oxidative stress. We investigated whether preconditioning exists on an endothelial level.
Akimitsu T., BERNHARD F. BECKER, CHRISTIAN KUPATT, DeFily D. V., Hearse D. J., Hoshida S., Jerome S. N., Schreck R., Schulz R., Siegfried M. R., STEFAN ZAHLER, Yao Z.   +11 more
core   +1 more source

Clinical Insights Into Hypercalcemia of Malignancy in Childhood

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Hypercalcemia of malignancy (HCM) is a rare but life‐threatening metabolic emergency in children that occurs in less than 1% of pediatric cancer cases, with a reported incidence ranging from 0.4% to 1.0% across different studies. While it is observed in 10%–20% of adult malignancies, pediatric HCM remains relatively uncommon.
Hüseyin Anıl Korkmaz
wiley   +1 more source

Levels of interleukins 6 and 8 in Psoriatic patients serum

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2017
  Recent progress in the understanding of psoriasis has shown that the regulation of local and systemic cytokines plays an important role in its pathogenesis.
M. N. Iqbal
doaj  

Interleukin-8 is not a predictive biomarker for the development of the acute promyelocytic leukemia differentiation syndrome

BMC Cancer, 2020
Background Differentiation syndrome (DS) is the main life-threatening adverse event that occurs in acute promyelocytic leukemia (APL) patients treated with all-trans retinoic acid (ATRA).
Luciana Yamamoto de Almeida, Diego Antonio Pereira-Martins, Ana Sílvia Gouvêa Lima, Márcia Sueli Baggio, Luisa Corrêa de Araujo Koury, Ana Paula Lange, Sarah Cristina Bassi, Priscila Santos Scheucher, Eduardo Magalhães Rego   +8 more
doaj   +1 more source

Relationship and predictive role of the dual expression of FGFR and IL-8 in metastatic renal cell carcinoma treated with targeted agents [PDF]

, 2018
Background/Aim: The expression of IL-8 and FGFR has been related to prognosis and pathological features in renal cell carcinoma. We investigated the relationship between IL-8 and FGFR and the outcome in metastatic renal cell carcinoma (mRCC) patients ...
Carella, Consiglia, Ciardi, Antonio, Cortesi, Enrico, De Tursi, Michele, Iacovelli, Roberto, Mosillo, Claudia, Naso, Giuseppe, Natoli, Clara   +7 more
core   +1 more source