Results 151 to 160 of about 5,255,854 (171)

Semi-automated background removal limits data loss and normalizes imaging mass cytometry data [PDF]

Cytometry Part A: the Journal of the International Society for Analytical Cytology, 2021
Imaging mass cytometry (IMC) allows the detection of multiple antigens (approximately 40 markers) combined with spatial information, making it a unique tool for the evaluation of complex biological systems. Due to its widespread availability and retained
Noel De Miranda, Boudewijn Lelieveldt, Marieke E Ijsselsteijn   +2 more
exaly   +2 more sources

DNA-Conjugated Gold Nanoparticles as High-Mass Probes in Imaging Mass Cytometry

ACS Applied Bio Materials, 2019
We employ imaging mass cytometry (IMC) to investigate in vitro uptake and cellular distribution of DNA-functionalized gold nanoparticles (AuNPs). IMC enables the multiparametric imaging of cell components and allows for the detection of AuNPs in cells ...
Derek J Wilson, Chun Peng, Jennifer I L Chen   +2 more
exaly   +2 more sources

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Abstract 3588: Multiplex proteomics profiling with the imaging mass cytometry (IMC) identifies immune cell phenotypes associated with high NOS2/COX2 expression in ER- negative and TNBC patients

Cancer Research, 2023
Abstract Elevated expression of Inducible Nitric oxide Synthase-2 (NOS2) occurs during acute and chronic inflammation and wound healing processes however, it is also a predictor of bad prognosis in aggressive ER-negative tumors. Overexpression of NOS2 correlates with other prognostic biomarkers making it a unique multifunctional ...
Milind Pore, Lisa Ridnour, Paul Mallory, Ashley Cardamone, Stephen Lockett, William Bocik, David Wink   +6 more
openaire   +1 more source

Abstract 232: Qualitative Single-cell Assessment By Imaging Mass Cytometry (imc) Analysis Reveals Senescence-associated Stemness (sas) Induced By Erk5 S496 Phosphorylation In Atherosclerotic Plaque

Arteriosclerosis, Thrombosis, and Vascular Biology, 2022
The central role of ERK5 S496 phosphorylation in promoting senescence has been reported. Recently the conventional model of senescence as an event of cell cycle arrest has been challenged, given that senescence induced by various stresses reprograms cancer cells to acquire senescence-associated stemness (SAS), which allows them to escape ...
Sivareddy Kotla, Masaki Imanishi, Shengyu Li, Kyung Ae Ko, Venkatasubrahman K Samanthapudi, Hannah Savage, Keri Schadler, Ying H Shen, Anita M Deswal, Steven Lin, Cielito Reyes-Gibby, Sai-Ching Yeung, Henry J Pownall, Keigi Fujiwara, Jared K Burks, Nhat-Tu Le, Guangyu Wang, Jun-ichi Abe   +17 more
openaire   +1 more source

Research Techniques Made Simple: Use of Imaging Mass Cytometry for Dermatological Research and Clinical Applications [PDF]

Journal of Investigative Dermatology, 2021
Traditional immunohistochemistry (IHC) is inherently limited by its ability to analyze only several markers within a histological tissue section at a given time, which hinders in-depth characterization and phenotyping of tissues.
David M Ozog, Qing-Sheng Mi, Jesse Veenstra   +2 more
exaly   +2 more sources

Abstract 1144: Development of imaging mass cytometry (IMC) as a tool to characterize circulating tumor cells (CTCs) in pre-clinical mouse models

Cancer Research
Abstract Metastasis is in part due to circulating tumor cells (CTCs), especially CTC clusters, which are associated with poor prognosis and treatment resistance. CTCs increase in numbers after biopsy, surgery, and during neo-adjuvant treatment.
Milind Pore, Balamurugan Kuppusamy, Devynn Breen, Paul Mallory, Abigail Atkinson, Ashley Cardamone, Christine Newkirk, Lois McKennett, Shikha Sharan, William Bocik, Esta Sterneck   +10 more
openaire   +1 more source

Abstract 7124: Imaging mass cytometry (IMC) reveals distinct intratumoral B and T regulatory cell populations in responder versus non-responder soft tissue sarcoma (STS) patients before treatment with immune checkpoint blockade (ICB)

Cancer Research
Abstract Background: STS are poorly understood cancers for which systemic therapy options are limited. Recent evidence suggests that some patients with two types of STS (undifferentiated pleomorphic sarcoma, UPS; dedifferentiated liposarcoma, DDLPS) benefit from ICB.
Laurence P. Diggs, Elise Nassif Haddad, Susmita Kumari, Varshini Arunkumar, Sammy Ferri-Borgogno, Samuel Mok, Duncan Mak, Angelique Lin, Madeline McAllister, Akshay Basi, Manoj Chelvanambi, Javier Gomez, Jared Burks, Davis Ingram, Khalida Wani, Natalie Duarte, Trevor McKee, Alexander Lazar, Jennifer Wargo, Christina Roland, Emily Keung   +20 more
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(1265) Exploration of Intragraft T Cell Phenotypes in Minimal Acute Cellular Rejection (ACR) Using Imaging Mass Cytometry (IMC)

The Journal of Heart and Lung Transplantation, 2023
S. Beber, S. Moshkelgosha, M. Cheung, D. Hedley, L. Levy, J. Samuels, B. Renaud-Picard, D. Hwang, T. Martinu, S. Juvet   +9 more
openaire   +1 more source

Insights into highly multiplexed tissue images: A primer for Mass Cytometry Imaging data analysis

TrAC - Trends in Analytical Chemistry, 2022
Yaquan Liu
exaly  

Research Techniques Made Simple: Experimental Methodology for Imaging Mass Cytometry

Journal of Investigative Dermatology, 2021
Vincent Piguet, Lihi Eder, Saeed Khalili
exaly