Recent Progress in Metal-Free Direct Synthesis of Imidazo[1,2-a]pyridines. [PDF]
ACS Omega, 2021 This Mini-Review highlights the most effective protocols for metal-free direct synthesis of imidazo[1,2-a]pyridines, crucial target products and key intermediates, developed in the past decade.
Kurteva V.
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HPW-Catalyzed environmentally benign approach to imidazo[1,2-a]pyridines. [PDF]
Beilstein J Org ChemThe imidazo[1,2-a]pyridine moiety is present in drugs with several biological activities. The most direct way of obtaining this nucleus is the Groebke–Blackburn–Bienaymé three-component reaction (GBB-3CR) between aminopyridines, aldehydes, and ...
Martinho LA, Andrade CKZ.
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Microwave-Assisted One-Pot Telescoped Synthesis of 2-Amino-1,3-thiazoles, Selenazoles, Imidazo[1,2-<i>a</i>]pyridines, and Other Heterocycles from Alcohols. [PDF]
J Org ChemPrimary and secondary alcohols have been con-verted into 2-amino-1,3-thiazoles under microwave irradiation,employing trichloroisocyanuric acid (TCCA) as a dual oxidant andchlorine source, TEMPO as a co-oxidant, and thiourea. Secondaryalcohols underwent a
Macías-Benítez P +3 more
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Diversity-Oriented Synthesis of [2.2]Paracyclophane-derived Fused Imidazo[1,2-a]heterocycles by Groebke-Blackburn-Bienayme Reaction : Accessing Cyclophanyl Imidazole Ligands Library [PDF]
, 2021 This report describes the synthesis of a [2.2]paracyclophane-derived annulated 3-amino-imidazole ligand library through a Groebke-Blackburn-Bienayme three-component reaction (GBB-3CR) approach employing formyl-cyclophanes in combination with diverse ...
Brase, Stefan +6 more
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A Dual Read-Out Assay to Evaluate the Potency of Compounds Active against Mycobacterium tuberculosis [PDF]
, 2012 PMCID: PMC3617142This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
Alling, T +7 more
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Rapid, metal-free and aqueous synthesis of imidazo[1,2-a]pyridine under ambient conditions [PDF]
, 2016 A novel, rapid and efficient route to imidazo[1,2-a]pyridines under ambient, aqueous and metal-free conditions is reported. The NaOH-promoted cycloisomerisations of N-propargylpyridiniums give quantitative yield in a few minutes (10 g scale).
A. John Blacker +54 more
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Phosphorylated imidazo[1,2‐a]pyridines
Heteroatom Chemistry, 1995 AbstractThe reaction of phosphorus(III) halides with imidazo[1,2‐a]pyridines in the presence of bases leads to the formation of 3‐phosphorylated imidazo[1,2‐a]pyridines. The reaction proceeds in high yield and requires no catalysts.In the compounds obtained, in contrast to phosphorylated indolizines, the phosphorus–heterocycle bond is stable and not ...
Andrew A. Tolmachev +5 more
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Fluorination methods in drug discovery [PDF]
, 2016 Fluorination reactions of medicinal and biologically-active compounds will be discussed. Late stage fluorination strategies of medicinal targets have recently attracted considerable attention on account of the influence that the fluorine atom can impart ...
Bonesi, Sergio Mauricio +2 more
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An easy preparation of pyridinium N-heteroarylaminides [PDF]
, 2004 A synthesis of substituted pyridinium N-heteroarylaminides, e.g., I, is reported. Heteroaryl chlorides underwent nucleophilic substitution with N-aminopyridinium iodide to give the corresponding substituted pyridinium N-heteroarylaminides in good yields.
Burgos García, Carolina +3 more
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Novel Strategies for Fluorine‐18 Radiochemistry [PDF]
, 2012 Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90272/1/1106_ftp ...
Agard +23 more
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