Hybrid of Indolizine and Merocyanine-A New Class of Organelle-Specific Dyes. [PDF]
Angew Chem Int Ed EnglThe new merocyanines and cyanines possessing an indolizine scaffold were synthesized via tandem Friedel–Crafts alkylation followed by nucleophilic aromatic substitution, by leveraging the special reactivity of 2,3,5,6‐tetrafluoro‐4‐hydroxybenzaldehyde.
Badaro JSA +9 more
europepmc +3 more sources
A Novel Solvent-free Approach to Imidazole containing Nitrogen-Bridgehead Heterocycles [PDF]
, 2013 A very simple domino reaction under solvent free conditions of various piridine-like heterocycles with 1,2-diaza-1,3-dienes produces in good yields imidazo[1,2-a]pyridines, imidazo[1,2-a]quinolines and imidazo[2,1-a]isoquinolines.
ATTANASI, ORAZIO ANTONIO +5 more
core +1 more source
Silica-ZnCl 2 : An Efficient Catalyst for the Synthesis of 4-Methylcoumarins [PDF]
, 2013 Silica-ZnCl2 has been found to be an efficient and eco-friendly catalyst for the synthesis of substituted 4-methylcoumarins from ethyl acetoacetate and substituted phenols under “neat” conditions in an oil bath at 80°C.
Bandita Datta, . +2 more
core +1 more source
Synthesis and applications of fused N- and O-heterocyclic systems from nitrodienic building-blocks [PDF]
, 2022 N-containing and O-containing heterocycles are widely distributed in natural products essential for life and are often responsible for the pharmaceutical activity of a lot of drugs and lead-compounds. Exploiting the electrophilic nature of functionalized
Benzi, Alice
core +1 more source
Short synthesis and anti-rhinoviral activity of imidazo[1,2-a]pyridines: the effect of acyl groups at 3-position [PDF]
, 1999 Various 2-amino-3-acyl-6-[(E)-1-phenyl-2-N-methylcarbamoylvinyl]-imidazo[1,2-a]pyridines, structurally related to Enviroxime were prepared to determine the effect of acyl groups on the antirhinoviral activity.
Ezquerra, Jesús +5 more
core +2 more sources
Mycobacterial Interspersed Repetitive Unit Can Predict Drug Resistance of Mycobacterium tuberculosis in China [PDF]
, 2016 BackgroundRecently, Mycobacterial Interspersed Repetitive Unit (MIRU) was supposed to be associated with drug resistance in M.tuberculosis (MTB). However, whether the MIRU was related to drug resistance actually was still unknown.
Chao Jiang +7 more
core +2 more sources
PREPARATION OF NEW NITROGEN-BRIDGED HETEROCYCLES. 63. UNEXPECTED FORMATION OF THIENO[3 ',4 ':4,5]IMIDAZO[1,2-a]-PYRIDINES [PDF]
, 2008 The alkaline treatment and dehydrogenation of pyridinium salts, obtainable from the S-alkylation of 3,5-dimethylpyridinium 2-alkylthio-1-cyano2-thioxoethylides with some phenacyl bromides, afforded unexpected heterocycles, 3-alkylthio-1-arylcarbonyl-6,8 ...
Abe, T +3 more
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Synthetic and theoretical studies of novel ring closure and ring opening reactions [PDF]
, 2006 Ring closure and ring opening reactions are in many cases useful synthetic procedures in organic chemistry. They allow the preparation of complex molecules with high stereoselectivity and good yields. Mechanistic and theoretical studies have been carried
González Rosende, Mª Eugenia +1 more
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Imidazo[1,2-a]pyridine-based peptidomimetics as inhibitors of Akt [PDF]
Bioorganic & Medicinal Chemistry Letters, 2014 We report the design, synthesis, and biological evaluation of imidazopyridine-based peptidomimetics based on the substrate consensus sequence of Akt, an AGC family serine/threonine kinase hyperactivated in over 50% of human tumors. Our ligand-based approach led to the identification of novel substrate mimetic inhibitors of Akt1 featuring an unnatural ...
Young B, Kim +5 more
openaire +2 more sources
Oxidative Cross-Coupling of sp\u3csup\u3e3\u3c/sup\u3e- and sp\u3csup\u3e2\u3c/sup\u3e-Hybridized C–H Bonds: Vanadium-Catalyzed Aminomethylation of Imidazo[1,2-\u3ci\u3ea\u3c/i\u3e]pyridines [PDF]
, 2015 The vanadium-catalyzed oxidative coupling of substituted 2-arylimidiazo[1,2-a]pyridines to N-methylmorpholine oxide, which acts as both a coupling partner and an oxidant, has been achieved.
DeBoef, Brenton +6 more
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