Results 31 to 40 of about 7,247 (206)

Synthesis of 3,5-Disubstituted Isoxazoles and Isoxazolines in Deep Eutectic Solvents [PDF]

, 2015
The synthesis of different 3,5-disubstituted isoxazoles and related isoxazolines using choline chloride:urea as deep eutectic solvent (DES) in a one-pot three step reaction has been accomplished successfully. The use of highly nucleophilic functionalized
Pérez Galera, Juana María, Ramón, Diego J.   +1 more
core   +3 more sources

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

Chemistry – A European Journal, Volume 31, Issue 67, December 1, 2025.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju, Davide Benedetto Tiz, Adrian Iles, Janez Košmrlj, Ross D. Jansen‐van Vuuren   +4 more
wiley   +1 more source

Recent Synthetic Advances in C–H/N–H Functionalization of 1H‐Pyrazoles: Diverse Strategies Across Variously Substituted Scaffolds

The Chemical Record, Volume 25, Issue 12, December 2025.
Systematic overview of pyrazole functionalization reactions from C‐5 to N−H. It covers different strategies, from traditional cross‐coupling of prefunctionalized pyrazoles to more efficient direct functionalizations. This review briefly and systematically overviews C–H and N–H functionalization reactions of pyrazoles, aimed at creating new CC and C ...
Karolina Dzedulionytė Müldür, Asta Žukauskaitė, Algirdas Šačkus, Eglė Arbačiauskienė   +3 more
wiley   +1 more source

Pyridine-3-carboxamide-6-yl-ureas as novel inhibitors of bacterial DNA gyrase: Structure based design, synthesis, SAR and antimicrobial activity [PDF]

, 2014
The development of antibacterial drugs based on novel chemotypes is essential to the future management of serious drug resistant infections. We herein report the design, synthesis and SAR of a novel series of N-ethylurea inhibitors based on a pyridine-3 ...
Czaplewski, LG, Davies, DT, Fishwick, CWG, Narramore, SK, Pommier, S, Yule, IA   +5 more
core   +1 more source

Synthesis of Poly‐Substituted Imidazo[1,2‐a]Pyridines via a Double Annulation Strategy

Asian Journal of Organic Chemistry, Volume 14, Issue 11, November 2025.
Herein, we report a novel and efficient synthetic strategy for the construction of poly‐substituted imidazo[1,2‐a]pyridines from the reaction of enaminonitriles with propargylamines via a domino conjugate substitution–nucleophilic addition‐cycloisomerization process.
Myungho Jung, Sunhee Lee, Dohui Ku, Dageum Kang, Ikyon Kim   +4 more
wiley   +1 more source

The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion [PDF]

, 2016
Citation: Miyazaki, H., Wangemann, P., & Marcus, D. C. (2016). The gastric H,K-ATPase in stria vascularis contributes to pH regulation of cochlear endolymph but not to K secretion. BMC Physiology, 17(1), 1.
Marcus, Daniel C., Miyazaki, Hiromitsu, Wangemann, Antje Philine   +2 more
core   +1 more source

Gas Chromatography‐Mass Spectrometry Analysis, Genoprotective, and Antioxidant Potential of Curio radicans (L. f.) P.V. Heath

ChemistryOpen, Volume 14, Issue 11, November 2025.
The ethyl acetate extract of Curio radicans is found to contain a higher proportion of bioactive compounds (55% vs 30% in the ethanolic extract) by gas chromatography‐mass spectrometry, and it exhibits stronger antioxidant activity in the DPPH assay (75% vs 65% inhibition) as well as clear genoprotective effects against H2O2‐induced DNA damage ...
Muhammad Naseer, Muhammad Adil, Sarir Ahmad, Mikhlid H. Almutairi, Abdulwahed Fahad Alrefaei, Sajid Ali, Fayaz Asad   +6 more
wiley   +1 more source

Efficient Synthesis of 1‐Chloroimidazo[1,2‐a:4,5‐c']dipyridines, Versatile Synthons for Position‐1 Functionalisation with Various Reagents

ChemistryOpen, Volume 14, Issue 11, November 2025.
Imidazo[1,2‐a:4,5‐c']dipyridines are remarkable skeletons in the field of medicinal chemistry. This article presents the synthesis of 1‐chloroimidazo[1,2‐a:4,5‐c']dipyridines, versatile synthons to functionalize at position‐1. Several examples of further reactions are presented, including Suzuki–Miyaura and Sonogashira cross‐couplings, nucleophilic ...
Romain Dussart, Mélanie Pénichon, Pierre‐Olivier Delaye, Cécile Enguehard‐Gueiffier   +3 more
wiley   +1 more source

Tandem Flavin-Iodine-Catalyzed Aerobic Oxidative Sulfenylation of Imidazo[1,2- a]Pyridines with Thiols.

Journal of Organic Chemistry, 2018
A green, aerobic sulfenylation of imidazo[1,2- a]pyridines was performed using thiols, a flavin-and-iodine dual catalytic system, and environmentally benign molecular oxygen as the only sacrificial reagent.
Hiroki Iida, Ryuta Demizu, Ryoma Ohkado
semanticscholar   +1 more source

Nongenotoxic 3-Nitroimidazo[1,2-a]pyridines Are NTR1 Substrates That Display Potent in Vitro Antileishmanial Activity [PDF]

, 2019
Twenty nine original 3-nitroimidazo[1,2-a]pyridine derivatives, bearing a phenylthio (or benzylthio) moiety at position 8 of the scaffold, were synthesized.
Azas, Nadine, Basmaciyan, Louise, Belle Mbou, Valère, Boudot, Clotilde, Bourgeade-Delmas, Sandra, Boutet-Robinet, Élisa, Casanova, Magali, Castera-Ducros, Caroline, Cohen, Anita, Courtioux, Bertrand, Fairlamb, Alan H., Fersing, Cyril, Hutter, Sébastien, Laget, Michèle, Milne, Rachel, Pedron, Julien, Piednoel, Mélanie, Primas, Nicolas, Rathelot, Pascal, Since, Marc, Sournia-Saquet, Alix, Valentin, Alexis, Vanelle, Patrice, Verhaeghe, Pierre, Wyllie, Susan   +24 more
core   +4 more sources