Evolutionary convergence in the biosyntheses of the imidazole moieties of histidine and purines. [PDF]
PLoS ONE, 2018 The imidazole group is an ubiquitous chemical motif present in several key types of biomolecules. It is a structural moiety of purines, and plays a central role in biological catalysis as part of the side-chain of histidine, the amino acid most ...
Alberto Vázquez-Salazar +2 more
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Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes
Pharmaceutics, 2023 The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily
Shu-Rui Li +3 more
semanticscholar +1 more source
Synthesis and therapeutic potential of imidazole containing compounds
BMC Chemistry, 2021 Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. It is also known as 1, 3-diazole.
Ankit Siwach, P. Verma
semanticscholar +1 more source
Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction
Drug Design, Development and Therapy, 2021 Various imidazole-containing compounds have been tested for their medical usefulness in clinical trials for several disease conditions. The rapid expansion of imidazole-based medicinal chemistry suggests the promising and potential therapeutic values of ...
S. Alghamdi +4 more
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Chemistry Proceedings, 2021 2,4,5-Trisubstituted imidazole derivatives with heteroaromatic groups are versatile heterocyclic compounds exhibiting a wide range of biological activities, as well as very interesting thermal, optical, electronic, and redox properties.
Odília M. P. F. Luís +3 more
doaj +1 more source
Nature Communications, 2020 Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism.
A. Molinaro +110 more
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Adsorption of imidazole on Au(111) surface: Dispersion corrected density functional study [PDF]
, 2016 We use density functional theory in the generalized gradient approximation to study the adsorption of imidazole on the Au(111) surface and account for dispersion effect using Grimme's empirical dispersion correction technique.
Abou El Makarim, Hassna +4 more
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In vivo imaging of pyrrole-imidazole polyamides with positron emission tomography [PDF]
, 2008 The biodistribution profiles in mice of two pyrrole-imidazole polyamides were determined by PET. Pyrrole-imidazole polyamides are a class of small molecules that can be programmed to bind a broad repertoire of DNA sequences, disrupt transcription factor ...
Bergstr m +26 more
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Synthesis of Imidazole-Based Medicinal Molecules Utilizing the van Leusen Imidazole Synthesis
Pharmaceuticals, 2020 Imidazole and its derivatives are one of the most vital and universal heterocycles in medicinal chemistry. Owing to their special structural features, these compounds exhibit a widespread spectrum of significant pharmacological or biological activities ...
Xunan Zheng, Zhengning Ma, Dawei Zhang
semanticscholar +1 more source
Thiacalix[4]arene derivatives bearing imidazole units : a ditopic hard/soft receptor for Na⁺ and K⁺/Ag⁺ with an allosteric effect and a reusable extractant for dichromate anions [PDF]
, 2016 © 2016 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim Two novel receptors 5,11,17,23-tetra-tert-butyl-25,27-bis[(ethoxycarbonyl)methoxy]-26,28-bis-[1-methyl-(imidazole)meth-oxy] -2,8,14,20-tetra-thiacalix[4]arene (L1) and 5,11,17,23-tetra-tert-butyl-25,27 ...
Akgemci +40 more
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