Results 11 to 20 of about 334,731 (408)
Evolutionary convergence in the biosyntheses of the imidazole moieties of histidine and purines. [PDF]
PLoS ONE, 2018 The imidazole group is an ubiquitous chemical motif present in several key types of biomolecules. It is a structural moiety of purines, and plays a central role in biological catalysis as part of the side-chain of histidine, the amino acid most ...
Alberto Vázquez-Salazar +2 more
doaj +2 more sources
Comprehensive Insights into Medicinal Research on Imidazole-Based Supramolecular Complexes
Pharmaceutics, 2023 The electron-rich five-membered aromatic aza-heterocyclic imidazole, which contains two nitrogen atoms, is an important functional fragment widely present in a large number of biomolecules and medicinal drugs; its unique structure is beneficial to easily
Shu-Rui Li +3 more
semanticscholar +1 more source
Synthesis and therapeutic potential of imidazole containing compounds
BMC Chemistry, 2021 Imidazole is a five-membered heterocyclic moiety that possesses three carbon, two nitrogen, four hydrogen atoms, and two double bonds. It is also known as 1, 3-diazole.
Ankit Siwach, P. Verma
semanticscholar +1 more source
Imidazole as a Promising Medicinal Scaffold: Current Status and Future Direction
Drug Design, Development and Therapy, 2021 Various imidazole-containing compounds have been tested for their medical usefulness in clinical trials for several disease conditions. The rapid expansion of imidazole-based medicinal chemistry suggests the promising and potential therapeutic values of ...
S. Alghamdi +4 more
semanticscholar +1 more source
Mechanism of imidazole inhibition of a GH1 β‐glucosidase
FEBS Open Bio, 2023 Imidazole is largely employed in recombinant protein purification, including GH1 β‐glucosidases, but its effect on the enzyme activity is rarely taken into consideration.
Rafael S. Chagas +4 more
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Cholinesterase-like organocatalysis by imidazole and imidazole-bearing molecules [PDF]
Scientific Reports, 2017 AbstractOrganocatalysis, which is mostly explored for its new potential industrial applications, also represents a chemical event involved in endogenous processes. In the present study, we provide the first evidence that imidazole and imidazole derivatives have cholinesterase-like properties since they can accelerate the hydrolysis of acetylthiocholine
NIERI, PAOLA +5 more
openaire +4 more sources
Chemistry Proceedings, 2021 2,4,5-Trisubstituted imidazole derivatives with heteroaromatic groups are versatile heterocyclic compounds exhibiting a wide range of biological activities, as well as very interesting thermal, optical, electronic, and redox properties.
Odília M. P. F. Luís +3 more
doaj +1 more source
Nature Communications, 2020 Microbiota-host-diet interactions contribute to the development of metabolic diseases. Imidazole propionate is a novel microbially produced metabolite from histidine, which impairs glucose metabolism.
A. Molinaro +110 more
semanticscholar +1 more source
Acta Crystallographica Section E: Crystallographic Communications, 2021 The asymmetric unit of the title coordination polymer, [Co(C9H4N2O4)(C2H4N4)]n or [Co(L1)(L2)]n, consists of one crystallographically independent Co2+ centre, one L12− ligand and one L2 ligand (L1 = 1H-benzimidazole-5,6-dicarboxylic acid, L2 = 3-amino-1 ...
Chen Zhao +5 more
doaj +1 more source
Adsorption of imidazole on Au(111) surface: Dispersion corrected density functional study [PDF]
, 2016 We use density functional theory in the generalized gradient approximation to study the adsorption of imidazole on the Au(111) surface and account for dispersion effect using Grimme's empirical dispersion correction technique.
Abou El Makarim, Hassna +4 more
core +1 more source