Results 51 to 60 of about 303,026 (334)

Synthesis, chemical and biological properties of the new mono- and bis-derivatives of imidazoles

Aktualʹnì Pitannâ Farmacevtičnoï ì Medičnoï Nauki ta Praktiki, 2014
The aim of research. The problem of finding effective antitumour medical preparation with low toxicity is an important issue of medical and pharmaceutical chemistry. Knowledge of cancer cell features and its metabolism enables to predict the direction of
E. V. Welchinska
doaj   +1 more source

Synthesis and Characterization of Proton-Conducting Composites Prepared by Introducing Imidazole or 1,2,4-Triazole into AlPO-5 and SAPO-5 Molecular Sieves

Molecules, 2023
The present work concerns proton-conducting composites obtained by replacing the water molecules present in aluminophosphate and silicoaluminophosphate AFI-type molecular sieves (AlPO-5 and SAPO-5) with azole molecules (imidazole or 1,2,4-triazole). Both
Adam Ostrowski, Aldona Jankowska, Agata Tabero, Ewa Janiszewska, Stanisław Kowalak   +4 more
doaj   +1 more source

Modeling solid state stability for speciation: a ten-year long study [PDF]

, 2019
Speciation studies are based on fundamental models that relate the properties of biomimetic coordination compounds to the stability of the complexes. In addition to the classic approach based on solution studies, solid state properties have been recently
Buiarelli, Francesca, Carcassi, Elena, Gullifa, Giuseppina, Materazzi, Stefano, Risoluti, Roberta, Wo, Li W.   +5 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Synthesis and Biological Evaluation of Novel Imidazole Derivatives as Antimicrobial Agents

Biomolecules
Imidazole derivatives are considered potential chemical compounds that could be therapeutically effective against several harmful pathogenic microbes.
Huda A. Al-Ghamdi, Fahad A. Almughem, Manal A. Alshabibi, Abrar A. Bakr, Abdullah A. Alshehri, Alhassan H. Aodah, Nourah A. Al Zahrani, Essam A. Tawfik, Laila A. Damiati   +8 more
doaj   +1 more source

Second generation silver(I)-mediated imidazole base pairs

Beilstein Journal of Organic Chemistry, 2014
The imidazole–Ag(I)–imidazole base pair is one of the best-investigated artificial metal-mediated base pairs. We show here that its stability can be further improved by formally replacing the imidazole moiety by a 2-methylimidazole or 4-methylimidazole ...
Susanne Hensel, Nicole Megger, Kristina Schweizer, Jens Müller   +3 more
doaj   +1 more source

Imidazole aldoximes effective in assisting butyrylcholinesterase catalysis of organophosphate detoxification. [PDF]

, 2014
Intoxication by organophosphate (OP) nerve agents and pesticides should be addressed by efficient, quickly deployable countermeasures such as antidotes reactivating acetylcholinesterase or scavenging the parent OP.
Amitai, Gabriel, Fokin, Valery V, Radić, Zoran, Sharpless, K Barry, Sit, Rakesh K, Taylor, Palmer   +5 more
core  

A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms

FEBS Open Bio, EarlyView.
We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley   +1 more source

[(1,2,5,6-η)-Cycloocta-1,5-diene](1-ethyl-3-isopropyl-1,3-imidazol-2-ylidene-κC2)(triphenylphosphane-κP)iridium(I) tetrafluoridoborate

IUCrData, 2017
In the title compound, [Ir(C8H12)(C8H14N2)(C18H15P)]BF4, the cationic complex has the anticipated square-planar geometry. The asymmetric unit comprises the iridium complex and one tetrafluoridoborate anion.
Karam B. Idrees, William J. Rutledge, Sue A. Roberts, Edward Rajaseelan   +3 more
doaj   +1 more source

In Vitro and In Silico Screening of 2,4,5-Trisubstituted Imidazole Derivatives as Potential Xanthine Oxidase and Acetylcholinesterase Inhibitors, Antioxidant, and Antiproliferative Agents

Applied Sciences, 2020
The employment of privileged scaffolds in medicinal chemistry supplies scientists with a solid start in the search for new and improved therapeutic molecules.
Eduardo Noriega-Iribe, Laura Díaz-Rubio, Arturo Estolano-Cobián, Victor Wagner Barajas-Carrillo, José M. Padrón, Ricardo Salazar-Aranda, Raúl Díaz-Molina, Victor García-González, Rocio Alejandra Chávez-Santoscoy, Daniel Chávez, Iván Córdova-Guerrero   +10 more
doaj   +1 more source