Results 161 to 170 of about 95,350 (343)

Mutual Exclusion Analysis Shows that DUSP9 Negatively Regulates PD‐L1 Expression and Acts as a Target to Enhance Anti‐PD‐1 Efficacy

Advanced Science, EarlyView.
A mutually exclusive screening system is established to identify negative regulators of highly plastic genes. Dual specificity phosphatase (DUSP9) is a novel negative regulatory molecule of PD‐L1 by dephosphorylating STAT3, and acts as a target molecule in combination with PD‐1 antibody for tumor immunotherapy and a new clinical biomarker for ...
Yuzhe Hu, Ling Tang, Zheng Kuang, Danyi Huang, Ting Li, Gaofei Yin, Yingyu Chen, Wei Guo, Wenling Han, Pingzhang Wang   +9 more
wiley   +1 more source

Indole-Imidazole Hybrids as Emerging Therapeutic Scaffolds: Synthetic Advances and Biomedical Applications. [PDF]

Molecules
Bawazir WA, Ain Q.
europepmc   +1 more source

Forsythoside E Alleviates Liver Injury by Targeting PKM2 Tetramerization to Promote Macrophage M2 Polarization

Advanced Science, EarlyView.
Here, the study shows for the first time that Forsythoside E (FE) can promote PKM2 tetramerization by binding to its K311 site. Furthermore, it induces metabolic reprogramming of macrophages and inhibits NLRP3 expression. Finally, it can alleviate sepsis‐induced liver injury by promoting M2 anti‐inflammatory polarization.
Bingxin Wu, Xuechun Yu, Yanling Li, Lin An, Rongrong Zhang, Rong Zhang, Fan Zhang, Zhongqiu Liu, Caiyan Wang   +8 more
wiley   +1 more source

Dynamic Polymer Cross-linking Limits the Homogeneity of Compact Quantum Dots for Single-Particle Tracking. [PDF]

ACS Appl Mater Interfaces
Arogundade OH, Kuo CW, Cui Y, Sarkar S, Feng Y, Kolossov VL, James S, Lee W, Smith AM.   +8 more
europepmc   +1 more source

Synthesis, Characterization And Biological Evaluation Of 1H-Substituted 2, 4, 5- Triphenyl Imidazole Derivatives

, 2018
E Ajila
openalex   +1 more source

Synthesis, thermal properties, conductivity and lifetime of proton conductors based on nanocrystalline cellulose surface-functionalized with triazole and imidazole

, 2020
Jadwiga Tritt‐Goc, Łukasz Lindner, Michał Bielejewski, Ewa Markiewicz, Radosław Pankiewicz   +4 more
openalex   +1 more source

Metal Complexes with Mixed Ligands. 22. Complex Formation between Cobalt(II) -- Imidazoles and Chloride Ions. A Potentiometric Study in Mixed 3.0 M (Na)ClO4,Cl Media. [PDF]

, 1981
Willis Forsling, Inger Granberg, Staffan Sjöberg, Lars Nordenskiöld, Olof Wahlberg   +4 more
openalex   +1 more source

Amodiaquine Enhances Anti‐Melanoma Efficacy of Attenuated Salmonella via Targeting Glutathione Reductase in Neutrophils

Advanced Science, EarlyView.
This study shows that Salmonella VNP20009 recruits pro‐tumor neutrophils that reduce its anticancer efficacy. Combining VNP with amodiaquine selectively eliminates these neutrophils by targeting glutathione reductase. A GR‐shRNA‐loaded VNP strain was further developed, demonstrating an innovative strategy integrating drug repurposing with synthetic ...
Wanfa Dong, Chunyuan Zhao, Chengxi Li, Lin Weng, Zehan Ji, Peiqi Li, Jiqiang Lu, Danni Liu, Anni Yu, Tianyi Jiang, Shaokai Huang, Heng Liu, Xiao Chen, Zichun Hua   +13 more
wiley   +1 more source

Benzo[<i>d</i>]imidazole-Naphthalen-Arylmethanone Regioisomers as CB₁ Ligands: Evaluation of Agonism via an Indirect Cytotoxicity-Based Approach. [PDF]

Int J Mol Sci
Hwa Cho AY, Burgos Ravanal R, Zuñiga Salazar V, Mellado M, Lorca M, Pessoa-Mahana D, Mella J, Günther Sapunar G, Romero-Parra J.   +8 more
europepmc   +1 more source

Novel bis-imidazole palladium catalysts. A study of their catalytic activity

, 1999
KJ Cavell, J.M. Rackham, Brian F. Yates, Michael J. Kilner   +3 more
openalex