Results 181 to 190 of about 52,674 (356)

Targeting Cystine Metabolism in the Lung Cancer Environment Enhances the Efficacy of Immune Checkpoint Inhibition

Advanced Science, EarlyView.
The tumor‐associated macrophages (TAMs) in lung cancer tissues exhibit active cystine metabolism. Restricting cystine concentration in macrophages induces M1 phenotypic polarization and upregulation of PD‐L1 expression through the GSH‐NF‐κB signaling pathway.
Yun Xu, Shumin Li, Jiaji Wu, Shumin Xu, Mo Shen, Chenyang Wang, Lundqvist Andreas, Jianghao Yu, Zhiyong Xu, Yueli Shi, Nana Liu, Yunke Yang, Jiangnan Zhao, Ying Yang, Pingli Wang, Peng Yi, Jin Cheng, Junhui Sun, Mengshu Li, Peng Xiao, Kai Wang   +20 more
wiley   +1 more source

Photo-induced decarboxylative radical cascade cyclization of unactivated alkenes: access to CF- and CF₂-substituted ring-fused imidazoles. [PDF]

RSC Adv
Wang H, Lin S, Hong H, Hu Z, Huang Y, Zhang X, Lin SN, Yang BM.   +7 more
europepmc   +1 more source

Rapid and Quantitative Chemical Exchange Saturation Transfer (CEST) Imaging with Magnetic Resonance Fingerprinting (MRF)

, 2017
Purpose: To develop a fast magnetic resonance fingerprinting (MRF) method for quantitative chemical exchange saturation transfer (CEST) imaging. Methods: We implemented a CEST-MRF method to quantify the chemical exchange rate and volume fraction of the
Cohen, Ouri, Farrar, Christian T., Huang, Shuning, McMahon, Michael T., Rosen, Matthew S.   +4 more
core  

SYNTHESIS OF IMIDAZOLE

A simple approach was used to prepare concentrated nitric acid supported on nano silica (HNO3@nanoSiO2). The synthetic powder was used as an efficient catalytic system for the synthesis of different 2,4,5-trisubstituted imidazoles in good to outstanding yields under solvent-free conditions at 100 C. Furthermore, 1,2,4,5-tetrasubstituted imidazoles have
openaire   +1 more source

Engineering Electron Transfer Flux between Cytochrome P450 Enzyme and P450 Reductase to Enhance Serotonin Production in Escherichia Coli

Advanced Science, EarlyView.
The electron transfer flux in CPR‐P450 catalytic system is systematically engineered through: i) enhancing electron transfer rate by redesigning the putative electron transfer pathway of CPR; ii) improving electron‐receiving rate by evolving the heme domain of tryptophan‐5‐hydroxylase (T5H); iii) enlarging electron supply by fine‐tuning NADPH synthesis.
Wenzhao Xu, Pengling Wei, Lirong Chen, Ling Gao, Xiaole Xia   +4 more
wiley   +1 more source

Green synthesis of imidazole derivatives in a ternary deep eutectic solvent system. [PDF]

Sci Rep
Mohammad F, Azizi N, Mirjafari Z, Mokhtari J.   +3 more
europepmc   +1 more source

Energietransport in Lösungen: Szintillation arylsubstituierter Imidazole¹ [PDF]

, 1965
Manfred Wilk, Karl-Heinz Peters
openalex   +1 more source

Natural Allelic Variations in IbCHYR1–IbZnFR Complex Regulate Fusarium Root Rot Resistance in Sweet Potato

Advanced Science, EarlyView.
FfRlpA2, a conserved Fusarium effector, functions as a protease inhibitor by hijacking the E3 ubiquitin ligase IbCHYR1 to degrade the resistance factor IbZnFR, thereby promoting Fusarium pathogenicity. Conversely, the high dosage Pro::IbZnFRHap2 allele was associated with resistance to root rot disease.
Huan Zhang, Zhuoru Dai, Xiaochen Zhang, Meiqi Shang, Xiaoru Gao, Ruiqi Ma, Limeng Zhao, Xiaoli Zhang, Qingchang Liu, Hong Zhai, Shaopei Gao, Ning Zhao, Qinghe Cao, Qiang Li, Shaozhen He   +14 more
wiley   +1 more source

Visible-light-promoted radical cyclisation of unactivated alkenes in benzimidazoles: synthesis of difluoromethyl- and aryldifluoromethyl-substituted polycyclic imidazoles. [PDF]

Beilstein J Org Chem
Pang Y, Yan J, Al-Maharik N, Zhang Q, Fang Z, Li D.   +5 more
europepmc   +1 more source

Studies on Acetylenic Compounds. XXII. Ring Closure. (4). New Synthesis of Thiazoles and Imidazole.

, 1962
Yasuo Yura
openalex   +2 more sources