Results 271 to 280 of about 95,350 (343)
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Polycyclic aromatic compounds (Print), 2020
This research reports a green and efficient protocol for the one-pot synthesis of dihydro-1H-indeno[1,2-b]pyridines and polysubstituted imidazoles using a recyclable acidic ionic liquid [H-NP]HSO4 (H-NPBS). Non-corrosiveness, safe, low waste, generality,
H. Alinezhad +3 more
semanticscholar +1 more source
This research reports a green and efficient protocol for the one-pot synthesis of dihydro-1H-indeno[1,2-b]pyridines and polysubstituted imidazoles using a recyclable acidic ionic liquid [H-NP]HSO4 (H-NPBS). Non-corrosiveness, safe, low waste, generality,
H. Alinezhad +3 more
semanticscholar +1 more source
Journal of Organic Chemistry, 2020
The first 1,3-dipolar cycloaddition of 2H-azirines with nitrones, a straightforward approach towards the regioselective synthesis of 1,2,4,5-tetrasubstituted imidazoles, is reported.
A. Angyal +4 more
semanticscholar +1 more source
The first 1,3-dipolar cycloaddition of 2H-azirines with nitrones, a straightforward approach towards the regioselective synthesis of 1,2,4,5-tetrasubstituted imidazoles, is reported.
A. Angyal +4 more
semanticscholar +1 more source
Journal of Medicinal Chemistry, 1975
A series of analogs of N-benzylimidazole was prepared and tested for hypolipidemic activity. Both plasma cholesterol and triglyceride-lowering activity were found in several members of the series. The most active compounds were N-3-methoxy-, N-4-methoxy-, and N-4-methylbenzylimidazole. Structure-activity relationships are discussed.
K H, Baggaley +5 more
openaire +2 more sources
A series of analogs of N-benzylimidazole was prepared and tested for hypolipidemic activity. Both plasma cholesterol and triglyceride-lowering activity were found in several members of the series. The most active compounds were N-3-methoxy-, N-4-methoxy-, and N-4-methylbenzylimidazole. Structure-activity relationships are discussed.
K H, Baggaley +5 more
openaire +2 more sources
American Pharmacy, 1991
Vaginal candidiasis is a common infection in women for which several effective therapeutic agents are currently available. Clotrimazole and miconazole were introduced in 1975, and both recently became available over the counter. These imidazole agents have largely replaced nystatin as primary therapy because of greater antifungal activity and shorter ...
C R, Lee, C A, McKenzie, A, Nobles
openaire +2 more sources
Vaginal candidiasis is a common infection in women for which several effective therapeutic agents are currently available. Clotrimazole and miconazole were introduced in 1975, and both recently became available over the counter. These imidazole agents have largely replaced nystatin as primary therapy because of greater antifungal activity and shorter ...
C R, Lee, C A, McKenzie, A, Nobles
openaire +2 more sources
Nanoparticle-Promoted Synthesis of Trisubstituted Imidazoles in a Green Medium
, 2020The imidazole ring system is one of the most important heterocyclic substructures and has been found in a large number of pharmacologically active compounds, including the fungicide ketoconazole, the proton pump inhibitor omeprazole, the antiulcerative ...
R. Khalifeh, Anahita Niknam
semanticscholar +1 more source
OH-Initiated Oxidation of Imidazoles in Tropospheric Aqueous-Phase Chemistry.
Journal of Physical Chemistry A, 2019Imidazoles formed via the reaction of dicarbonyls with nitrogen containing compounds in the atmospheric particle phase can be expected to initiate secondary organic aerosol (SOA) growth due to their potential to act as photosensitizers.
Tamara Felber, T. Schaefer, H. Herrmann
semanticscholar +1 more source
Journal of Agricultural and Food Chemistry, 2018
A molecular design approach was used in our laboratory to guide the development of imidazole-based fungicides. Based on homology modeling and molecular docking studies targeting the cytochrome P450-dependent sterol 14α-demethylase, 3,4 ...
Lai Chen +6 more
semanticscholar +1 more source
A molecular design approach was used in our laboratory to guide the development of imidazole-based fungicides. Based on homology modeling and molecular docking studies targeting the cytochrome P450-dependent sterol 14α-demethylase, 3,4 ...
Lai Chen +6 more
semanticscholar +1 more source
Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry, 2018
The low-melting mixture urea–ZnCl2 was evaluated as a novel reaction medium for the synthesis of imidazoles. The reaction between a dicarbonyl compound, ammonium acetate, and an aromatic aldehyde is efficiently catalyzed by the eutectic solvent, yielding
Natalia López Higuera +2 more
semanticscholar +1 more source
The low-melting mixture urea–ZnCl2 was evaluated as a novel reaction medium for the synthesis of imidazoles. The reaction between a dicarbonyl compound, ammonium acetate, and an aromatic aldehyde is efficiently catalyzed by the eutectic solvent, yielding
Natalia López Higuera +2 more
semanticscholar +1 more source
Imidazole: Fungitoxic Derivatives
Science, 1967Study of several new types of fungitoxic derivatives of imidazole reveals that imidazoles substituted on the imine nitrogen atom are likely to be active if the substituent is electron-attracting, and if the atom connecting it to the imidazolyl moiety has tetrahedral geometry.
H, Tolkmith +3 more
openaire +2 more sources
Synthesis of difluoromethylthio imidazole from methylthio imidazole
Journal of Fluorine Chemistry, 1996Abstract Demethylation of methylthio imidazole 1 via a Pummerer rearrangement onto the corresponding sulfoxide 2 afforded imidazole thiol 4 which was then difluoromethylated with the sodium chlorodifluoroacetate/NaI system in 71% overall yield.
Pierre Deprez, Jean-Paul Vevert
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