Results 151 to 160 of about 2,073 (211)

Comprehensive review of recent advances in Pompe disease: pathogenesis, management, and future directions. [PDF]

Front Neurol
Li G.
europepmc   +1 more source

Editorial: Fighting microbial biofilms: novel therapeutics and antibiofilm strategies. [PDF]

Front Cell Infect Microbiol
Paraje MG, Morató J, Gomes de Souza F.
europepmc   +1 more source

Pathological Protein Targets in Parkinson's Disease: Progress Towards the Development of Disease-Modifying Therapies. [PDF]

CNS Drugs
Dzamko N.
europepmc   +1 more source

Synthesis and chelation study of a fluoroionophore and a glycopeptide based on an aza crown iminosugar structure

Carbohydrate Research, 2021
Capitalizing on a recently reported iminosugar-based aza-crown (ISAC) accessed by a double Staudinger azaWittig coupling reaction, we have expanded the structural diversity of this new family of sweet cyclam analogs.
Ana Poveda, Jesús Jiménez-Barbero, Juan Xie   +2 more
exaly   +2 more sources

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Iminosugars as glycosyltransferase inhibitors

Organic & Biomolecular Chemistry, 2021
The review describes the syntheses and inhibition properties of pyrrolidine, piperidine, azepane, pyrrolizidine and indolizidine iminosugars, as well as iminosugar nucleotides and iminodi- and -oligosaccharides.
Irene Conforti, Alberto Marra
openaire   +2 more sources

Iminosugar thioglycosides as glycosyl donors: a route to disaccharides with an iminosugar moiety

Tetrahedron Letters, 2008
The iminosugar thioglycosides are used as glycosyl donors in glycosidation reactions. Thereby, iminosugar glycosides and disaccharide analogues with an iminosugar moiety are prepared. The yields are high and the method is stereoselective.
Manuel Angulo, Consolacion Gasch, José Fuentes   +2 more
exaly   +2 more sources

Synthesis and biological evaluation of ether bridged bicyclic iminosugar derivatives

Carbohydrate Research, 2009
Bicyclic iminosugar derivatives with an ether bridge bearing different substituents on C-2 and the nitrogen atom have been synthesized from a C-glycoside bearing an isopropylidene acetal.
An-Tai Wu, Wei Zou, Jiun-Ly Chir
exaly   +2 more sources

Enzyme inhibition by iminosugars: Analysis and insight into the glycosidase–iminosugar dependency of pH

Bioorganic & Medicinal Chemistry, 2013
Imino- and azasugar glycosidase inhibitors display pH dependant inhibition reflecting that both the inhibitor and the enzyme active site have groups that change protonation state with pH. With the enzyme having two acidic groups and the inhibitor one basic group, enzyme-inhibitor complexes with three (EH3I), two (EH2I), one (EHI), or no protons (EI ...
López, Óscar, Qing, Feng-Ling, Pedersen, Christian Marcus, Bols, Mikael   +3 more
openaire   +3 more sources

Iminosugar C-Nitromethyl Glycosides and Divergent Synthesis of Bicyclic Iminosugars

Organic Letters, 2017
An efficient one-pot method for the stereoselective synthesis of novel iminosugar C-nitromethyl glycosides is described. This new class of iminosugar glycosides has versatile nitromethyl functionality whose utility was further demonstrated in the single-step synthesis of bicyclic iminosugars.
Sure Siva Prasad, Soundararasu Senthilkumar, Akriti Srivastava, Sundarababu Baskaran   +3 more
openaire   +2 more sources

General Methods for Iminosugar Synthesis

Current Topics in Medicinal Chemistry, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
CIPOLLA, LAURA FRANCESCA, LA FERLA, BARBARA, NICOTRA, FRANCESCO   +2 more
openaire   +2 more sources