Results 161 to 170 of about 2,073 (211)

A Concise Enantioselective Synthesis of Iminosugar Derivatives.

ChemInform, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Wei-Wei, Liao, Ismail, Ibrahem, Armando, Córdova   +2 more
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An Expeditious Synthesis of Iminosugars

Australian Journal of Chemistry, 2010
A short and expedient synthesis of the potent glycosidase inhibitors, 1-deoxynojirimycin, miglitol, miglustat, 1-deoxymannojirimycin, and 1-deoxygalactonojirimycin is presented.
Michael N. Gandy, Matthew J. Piggott, Keith A. Stubbs   +2 more
openaire   +1 more source

Iminosugar-Producing Thai Medicinal Plants

Journal of Natural Products, 2005
Alpha-1-C-hydroxymethylfagomine (7), 3-O-beta-D-glucopyranosyl-DMDP (12), and 2,5-dideoxy-2,5-imino-D-glucitol (13) were isolated from the Thai traditional crude drug "Non tai yak" (Stemona tuberosa), which also contains a high concentration level of alpha-homonojirimycin (0.1% dry weight).
Naoki, Asano, Taku, Yamauchi, Koichi, Kagamifuchi, Naoko, Shimizu, Sachiko, Takahashi, Hitoshi, Takatsuka, Kyoko, Ikeda, Haruhisa, Kizu, Wongsatit, Chuakul, Aikkarach, Kettawan, Tadashi, Okamoto   +10 more
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Synthetic Access to the First Spirocyclopropyl Iminosugar

Synlett, 2006
AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
Christophe Laroche, Richard Plantier‐Royon, Jan Szymoniak, Philippe Bertus, Jean‐Bernard Behr   +4 more
openaire   +1 more source

Iminosugar C-Nitromethyl Glycoside: Stereoselective Synthesis of Isoxazoline and Isoxazole-Fused Bicyclic Iminosugars

The Journal of Organic Chemistry, 2018
A simple and efficient method for the stereoselective synthesis of isoxazoline/isoxazole-fused iminosugar derivatives has been developed using intramolecular nitrile oxide cycloaddition (INOC) as a key step. Iminosugar C-nitromethyl glycosides, derived from simple carbohydrates, served as excellent nitrile oxide precursors in 1,3-dipolar cycloaddition ...
Sure Siva Prasad, Sundarababu Baskaran
openaire   +2 more sources

Iminosugars as a new class of cholinesterase inhibitors

Bioorganic & Medicinal Chemistry Letters, 2015
To further extend the scope of iminosugar biological activity, a systematic structure-activity relationship investigation has been performed by synthesizing and evaluating as cholinesterase inhibitors a library of twenty-three iminoalditols with different substitutions and stereochemistry patterns.
Decroocq, Camille, Stauffert, Fabien, Pamlard, Olivier, Oulaïdi, Farah, Gallienne, Estelle, Martin, Olivier, Guillou, Catherine, Compain, Philippe   +7 more
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General Strategies for the Synthesis of Iminosugars and New Approaches Towards Iminosugar Libraries

2007
This chapter will provide an up-to-date review of synthetic methods for the preparation of iminosugars and related compounds. Iminosugars are still the object of intense synthetic investigations, both for the improvement of the synthetic methods and for the preparation of novel structures. Strategies from both sugars and non-carbohydrate precursors can
Barbara La Ferla, Francesco Nicotra, Laura Cipolla   +2 more
exaly   +2 more sources

Synthesis of multivalent iminosugars

2012
comunicazione ...
CARDONA, FRANCESCA, D'ADAMIO, GIAMPIERO, MATASSINI, CAMILLA, GOTI, ANDREA   +3 more
openaire   +1 more source

Iminosugars past, present and future: medicines for tomorrow

Drug Discovery Today, 2011
Iminosugars comprise the most attractive class of carbohydrate mimetics reported to date and are ideally positioned to take advantage of our increasing understanding of glycobiology in the search for new medicines. First-generation iminosugar drugs suffered from lack of adequate selectivity, resulting in considerable side-effects in the clinic. Current
Graeme, Horne, Francis X, Wilson, Jon, Tinsley, David H, Williams, Richard, Storer   +4 more
openaire   +2 more sources

gem-Diamine 1-N-Iminosugars and Related Iminosugars, Candidate of Therapeutic Agents for Tumor Metastasis

Current Topics in Medicinal Chemistry, 2003
Cancer metastasis is one of the major challenges in cancer research. Inhibitors of tumor metastasis are rapidly emerging as important new drug candidates for cancer therapy. Tumor metastasis formation occurs via a complex multistage process which involves a crucial step of tumor invasion through the basement membrane.
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