Results 221 to 230 of about 2,266,569 (385)

Strawberry Notch 1 Acts as a Transcriptional Regulator Driving Oncogenic Programs in Liver Carcinogenesis

Advanced Science, EarlyView.
This study reports that SBNO1 protein is upregulated in several cancer entities. SBNO1 protein interacts with the basal transcription factor TFIID via TAF4, enabling its recruitment to transcription start sites and the modulation of target gene expression.
Sarah Fritzsche, Raisatun Nisa Sugiyanto, Kira Gür, Alina Krumme, Maxime Le Marois, Angelika Fraas, Aslihan Inal, Mario Huerta, Vanessa Henriques, Eva Eiteneuer, Thomas Albrecht, Alphonse Charbel, Michael T. Dill, Carsten Sticht, Carolina De La Torre, Stefan Pusch, Arianeb Mehrabi, Kai Breuhahn, Junfang Ji, Peter Schirmacher, Benjamin Goeppert, Stephanie Roessler   +21 more
wiley   +1 more source

Epstein‐Barr Virus Expressed Long Non‐Coding RNA (lncBARTs) Regulate EBV Latent Genome Replication

Advanced Science, EarlyView.
EBV produces abundant level of lncBARTs, which are essential for maintaining viral genome replication in EBV‐associated cancers. LncBARTs interact with a complex comprising BRD4, CTCF and viral protein EBNA1 at EBV oriP region. This interaction tethers oriP to host chromosomes, facilitating EBV episome replication.
Jiayan Liu, Dittman Lai‐Shun Chung, Larry Ka‐Yue Chow, Shuo Han, Wenkai Yi, Conor J. Cremin, Yingyin Liao, Pui Wang, Bobo Wing‐Yee Mok, Mingfang Ji, Jian Yan, Wei Dai, Honglin Chen   +12 more
wiley   +1 more source

120MO Inupadenant combined with chemotherapy in patients with non-squamous NSCLC progressing on or after immune checkpoint inhibitor therapy: Results from dose-finding part of the A2A-005 trial

Kristof Cuppens, G. Lo Russo, Óscar Juan, E. Felip, Ma Carmen Areses Manrique, Alberto Chiappori, E. Govaerts, P.K. Cheema, L. Greillier, L. Toschi, Eric Schaefer, M. Clouseau, C. Martinoli, Hussein Shehade, Natalie Byrne, M. Fox, M. Rossetti, Olivier De Henau, S. Ross, S. Peters   +19 more
openalex   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Proteostasis of immune checkpoint receptors. [PDF]

Biochem J
Tey PY, Urbé S, Clague MJ.
europepmc   +1 more source

Table S14 from Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma

Chao Liu, Haoyi Zou, Yuli Ruan, Lin Fang, Bojun Wang, Luying Cui, Tong Wu, Zhuo Chen, Tianjiao Dang, Ya Lan, Wenyuan Zhao, Chunhui Zhang, Hongxue Meng, Yanqiao Zhang   +13 more
openalex   +1 more source

Effect of Liver Metastases on Survival in Microsatellite-Stable Metastatic Colorectal Cancer Treated with Immune Checkpoint Inhibitors [PDF]

Nussara Pakvisal, Leontios Pappas, Bennett Adam Caughey, Kuldeep Kumar, Noelia Tarazona, Kruti B. Vora, Ben Ouyang, Aditya Pandey, Bryan L. Peacker, Joie Sun, Leyre Zubiri, Kerry L. Reynolds, Ryan Dp, Motaz Qadan, Ryan B. Corcoran, Bruce Giantonio, Jill N. Allen, Elizabeth P. Walsh, Jefferey W. Clark, David Ting, Aparna R. Parikh   +20 more
openalex   +1 more source

Immune Checkpoint Inhibitor [PDF]

, 2020
openaire   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

Advanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen, Zichen Liu, Mengyi Wei, Qian Li, Liang Wu, Kunyuan Yu, Yanhong Xu, Dainan Yu, Wenwu Ma, Hongmei Wang, Ng Shyh‐Chang, Jinglei Zhai   +11 more
wiley   +1 more source

Breaking Barriers: Immune Checkpoint Inhibitors in Breast Cancer. [PDF]

Pharmaceutics
Dmuchowski B, Hryniewicz WW, Barczak I, Fręśko K, Szarzyńska Z, Węclewski H, Ślężak JK, Dobosz P, Gryczka H.   +8 more
europepmc   +1 more source