Results 51 to 60 of about 1,989,151 (330)
Immune Checkpoints Pathways in Head and Neck Squamous Cell Carcinoma
Cancers, 2021 Simple Summary During the last decades, scientific advances in immuno-oncology and a better understanding of tumors’ immune profile led to the development of novel immunotherapeutic strategies, especially immune checkpoint inhibitors.
Florencia Veigas +5 more
semanticscholar +1 more source
Unraveling the Role of Immune Checkpoints in Leishmaniasis
Frontiers in Immunology, 2021 Leishmaniasis are Neglected Tropical Diseases affecting millions of people every year in at least 98 countries and is one of the major unsolved world health issues. Leishmania is a parasitic protozoa which are transmitted by infected sandflies and in the
Rafael de Freitas e Silva, E. von Stebut
semanticscholar +1 more source
Soluble immune checkpoints in cancer: production, function and biological significance
Journal for ImmunoTherapy of Cancer, 2018 Immune checkpoints play important roles in immune regulation, and blocking immune checkpoints on the cell membrane is a promising strategy in the treatment of cancer.
Daqian Gu +4 more
doaj +1 more source
Single-cell immune checkpoint landscape of PBMCs stimulated with Candida albicans
Emerging Microbes and Infections, 2021 Immune checkpoints play various important roles in tumour immunity, which usually contribute to T cells’ exhaustion, leading to immunosuppression in the tumour microenvironment.
Weiwei Deng +11 more
doaj +1 more source
Immune checkpoint inhibitors in renal cell carcinoma [PDF]
, 2017 The immune system has long been known to play a critical role in the body's defence against cancer, and there have been multiple attempts to harness it for therapeutic gain.
Jones, Robert J., Ross, Kirsty
core +1 more source
CANCER IMMUNOTHERAPY BASED ON THE BLOCKADE OF IMMUNE CHECKPOINTS
Медицинская иммунология, 2015 Immune checkpoints represent the system of inhibitory mechanisms regulating the activation of the immune response, preventing the autoimmune processes and modulating the immune response by decreasing the immune cell-mediated damage of tissues and organs.
A. V. Bogolyubova +3 more
doaj +1 more source
Clinical Insights Into Novel Immune Checkpoint Inhibitors
Frontiers in Pharmacology, 2021 The success of immune checkpoint inhibitors (ICIs), notably anti-cytotoxic T lymphocyte associated antigen-4 (CTLA-4) as well as inhibitors of CTLA-4, programmed death 1 (PD-1), and programmed death ligand-1 (PD-L1), has revolutionized treatment options ...
Jii Bum Lee +3 more
doaj +1 more source
SnapShot: Immune Checkpoint Inhibitors
Cancer Cell, 2017 Immunotherapy has changed the landscape of cancer treatment. Checkpoint blockade therapies unleash breaks in the immune system and induce long-lasting responses. However, a significant number of patients do not respond (innate resistance), and a subset progress after responding (acquired resistance).
Abril-Rodriguez, Gabriel, Ribas, Antoni
openaire +4 more sources
Immune Checkpoints in Solid Organ Transplantation
Biology, 2023 Allogenic graft acceptance is only achieved by life-long immunosuppression, which comes at the cost of significant toxicity. Clinicians face the challenge of adapting the patients’ treatments over long periods to lower the risks associated with these ...
Arnaud Del Bello, Emmanuel Treiner
doaj +1 more source
LKB1 is essential for the proliferation of T-cell progenitors and mature peripheral T cells [PDF]
, 2010 The serine/threonine kinase LKB1 has a conserved role in Drosophila and nematodes to co-ordinate cell metabolism. During T lymphocyte development in the thymus, progenitors need to synchronize increased metabolism with the onset of proliferation and ...
Aifantis +50 more
core +5 more sources