Results 21 to 30 of about 593,447 (356)

A Pathogenic Role for FcγRI in the Immune Response against Chlamydial Respiratory Infection

Microorganisms, 2022
FcγRI is an important cell surface receptor reported to be involved in multiple immune responses, although it has not yet been extensively studied in intracellular bacterial infections. Here, using a mouse model of C.
Jiajia Zeng, Shuaini Yang, Ruoyuan Sun, Yuqing Tuo, Lu Tan, Hong Zhang, Yongci Zhang, Xuchun Che, Tingsha Lu, Xuejun Zhang, Hong Bai   +10 more
doaj   +1 more source

Research progress of MDSCs-targeted immunotherapy for pancreatic cancer

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Pancreatic cancer (PC) is a highly malignant digestive system tumor with a poor survival rate and prognosis. Most patients with pancreatic cancer have no obvious clinical manifestations in the early stage of the disease, and are found to be in the middle
QIN Yahan, ZHANG Ke, ZHANG Mengyu, SHEN Jie, PENG Meiyu   +4 more
doaj   +1 more source

Identification of novel immune subtypes and potential hub genes of patients with psoriasis

Journal of Translational Medicine, 2023
Background Psoriasis is a common, chronic and relapsing immune-related inflammatory dermal disease. Patients with psoriasis suffering from the recurrences is mainly caused by immune response disorder.
Yingxi Li, Lin Li, Yao Tian, Jing Luo, Junkai Huang, Litao Zhang, Junling Zhang, Xiaoxia Li, Lizhi Hu   +8 more
doaj   +1 more source

Interactions of Bacterial Toxin CNF1 and Host JAK1/2 Driven by Liquid-Liquid Phase Separation Enhance Macrophage Polarization

mBio, 2022
Urinary tract infections (UTIs) are a global public health concern, which is mainly caused by uropathogenic Escherichia coli (UPEC). Cytotoxic necrotizing factor 1 (CNF1) is a key UPEC toxin and regulates multiple host cellular processes through ...
Xuan Sun, Jianming Yang, Xueqin Deng, Yuting Wei, Changying Wang, Yaxiu Guo, Huan Yang, Liu Yang, Chunhui Miao, Junqiang Lv, Yawen Xiao, Hong Zhang, Zhi Yao, Quan Wang   +13 more
doaj   +1 more source

Tumor immune microenvironment (TIME) to enhance antitumor immunity

European Journal of Medical Research, 2023
AbstractThe tumor microenvironment is a result of dynamic interaction between different cellular and non-cellular components. In its essence it is not a solo performer, but an ensemble of performers that includes cancer cells, fibroblasts, myo-fibroblasts, endothelial cells and immune cells.
Sajin Rajbhandary, Hari Dhakal, Sudip Shrestha   +2 more
openaire   +3 more sources

The Immune Microenvironment of Myeloma [PDF]

Cancer Microenvironment, 2011
The bone marrow (BM) is the site of disease in myeloma and possesses unique immune characteristics involved in the pathobiology of the disease. Interactions of plasma cells with stromal cells, osteoclasts, osteoblasts, myeloid and lymphoid cells make up the unique bone marrow milieu that mediates myeloma disease progression.
Kimberly, Noonan, Ivan, Borrello
openaire   +2 more sources

Vascular Microenvironment, Tumor Immunity and Immunotherapy [PDF]

Frontiers in Immunology, 2021
Immunotherapy holds great promise for treating cancer. Nonetheless, T cell-based immunotherapy of solid tumors has remained challenging, largely due to the lack of universal tumor-specific antigens and an immunosuppressive tumor microenvironment (TME) that inhibits lymphocyte infiltration and activation.
Zachary Lamplugh, Yi Fan
openaire   +3 more sources

Pin1 Promotes NLRP3 Inflammasome Activation by Phosphorylation of p38 MAPK Pathway in Septic Shock

Frontiers in Immunology, 2021
Pin1 is the only known peptidyl-prolyl cis-trans isomerase (PPIase) that can specifically recognize and isomerize the phosphorylated Serine/Threonine-Proline (pSer/Thr-Pro) motif, change the conformation of proteins through protein phosphorylation, thus ...
Ruijie Dong, Zhenyi Xue, Guangyue Fan, Na Zhang, Chengzhi Wang, Guangliang Li, Yurong Da   +6 more
doaj   +1 more source

HEV-associated dendritic cells are observed in metastatic tumor-draining lymph nodes of cutaneous melanoma patients with longer distant metastasis-free survival after adjuvant immunotherapy

Frontiers in Immunology, 2023
IntroductionTissue biomarkers that aid in identifying cutaneous melanoma (CM) patients who will benefit from adjuvant immunotherapy are of crucial interest. Metastatic tumor-draining lymph nodes (mTDLN) are the first encounter site between the metastatic
Alicia Inés Bravo, Alicia Inés Bravo, Mariana Aris, Marylou Panouillot, Marylou Panouillot, Marylou Panouillot, Martina Porto, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Marie-Caroline Dieu-Nosjean, Jean-Luc Teillaud, Jean-Luc Teillaud, Jean-Luc Teillaud, María Marcela Barrio, José Mordoh, José Mordoh   +15 more
doaj   +1 more source

Pyroptosis, metabolism, and tumor immune microenvironment [PDF]

Clinical and Translational Medicine, 2021
AbstractIn response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic ...
Tiantian Du, Jie Gao, Peilong Li, Yunshan Wang, Qiuchen Qi, Xiaoyan Liu, Juan Li, Chuanxin Wang, Lutao Du   +8 more
openaire   +3 more sources