Results 51 to 60 of about 593,447 (356)

In the eye of the storm: T cell behavior in the inflammatory microenvironment. [PDF]

, 2013
Coordinated unfolding of innate and adaptive immunity is key to the development of protective immune responses. This functional integration occurs within the inflamed tissue, a microenvironment enriched with factors released by innate and subsequently ...
Haas, R, Marelli-Berg, F, Mauro, C
core   +1 more source

Microenvironment Cell Contribution to Lymphoma Immunity [PDF]

Frontiers in Oncology, 2018
Lymphoma microenvironment is a complex system composed of stromal cells, blood vessels, immune cells as well as extracellular matrix, cytokines, exosomes, and chemokines. In this review, we describe the function, localization, and interactions between various cellular components.
Deepika Kumar, Mina L. Xu
openaire   +3 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Research progress in the role of β-arrestin 1 in the regulation of inflammatory response

Shanghai Jiaotong Daxue xuebao. Yixue ban
The inflammatory response is a systemic process produced by the body in response to stimulation such as infection or injury. The inflammatory response is closely related to the pathogenesis of various diseases, and plays an important role in the ...
YI Wenjing, FAN Yixuan, QIU Jiatai, FU Xiaoyan, LIU Meifang   +4 more
doaj   +1 more source

CD24 blunts the sensitivity of retinoblastoma to vincristine by modulating autophagy

Molecular Oncology, 2020
Retinoblastoma (RB) is the most common childhood malignant intraocular tumor. The clinical efficacy of vincristine (VCR) in the treatment of RB is severely limited by drug resistance. Here, we found that CD24, a GPI‐anchored protein, was overexpressed in
Jie Sun, Dongju Feng, Huiyu Xi, Jiajing Luo, Zewei Zhou, Qinghuai Liu, Yun Chen, Qing Shao   +7 more
doaj   +1 more source

Tumour invasiveness, the local and systemic environment and the basis of staging systems in colorectal cancer [PDF]

, 2017
background: The present study aimed to examine the relationship between tumour invasiveness (T stage), the local and systemic environment and cancer-specific survival (CSS) of patients with primary operable colorectal cancer.
A Chrysanthopoulou, A Huijbers, AJ Munro, B Mlecnik, C Guastadisegni, C S D Roxburgh, CE Dukes, CH Richards, D C McMillan, D Church, D Hanahan, DC McMillan, F Pages, F Pages, FA Sinicrope, G Bindea, GJ Guthrie, H Ueno, H Ueno, H van Wyk, HC van Wyk, ID Nagtegaal, J Edwards, J Galon, J Guinney, J H Park, J Li, JB O'Connell, JH Park, JH Park, JH Park, JH Park, K Birkenkamp-Demtroder, K Klintrup, L De Smedt, LL Gunderson, LS Rozek, MJ Pollheimer, P G Horgan, P Quirke, R Salazar, S Ogino, SA Vayrynen, SS McAllister, T Kantola, VH Koelzer, W De Roock, WE Mesker   +47 more
core   +1 more source

The immune microenvironment of uterine adenosarcomas [PDF]

Clinical Sarcoma Research, 2020
Abstract Background Uterine adenosarcoma (UA) is an extremely rare sarcoma subtype. There has been limited evaluation of the immune microenvironment in these tumors. The objective of this study is to examine and describe the immune infiltrate and PD-1/PD-L1 expression in UA and to correlate these changes in the tumor ...
Ali, Ali Mohammed Refaat, Tsai, Jen-Wei, Leung, Cheuk Hong, Lin, Heather, Ravi, Vinod, Conley, Anthony P., Lazar, Alexander J., Wang, Wei-Lien, Nathenson, Michael J.   +8 more
openaire   +2 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Deficiency of NF‐Erythroid 2‐Related Factor 2 Exacerbates the Scar Through ERK Signaling Pathway

Immunity, Inflammation and Disease
Background Scar, primarily composed of poorly structured and disordered collagen, is mainly characterized by excessive fibroblast activation and abnormal collagen deposition.
Xueyuan Hao, Mengke Sun, Ruotong Wang, Hong Chen, Junkai Huang, Jing Luo, Haoyue Yu, Yingxi Li, Weibin Xing, Xiaoxia Li, Lizhi Hu   +10 more
doaj   +1 more source

Comparison of the prognostic value of measures of the tumor inflammatory cell infiltrate and tumor-associated stroma in patients with primary operable colorectal cancer [PDF]

, 2016
The aim of the present study was to compare the clinical utility of two measures of the inflammatory cell infiltrate - a H&E-based assessment of the generalised inflammatory cell infiltrate (the Klintrup-Mäkinen (KM) grade), and an ...
Edwards, J., Horgan, P. G., McMillan, D. C., Park, J. H., Roxburgh, Campbell S.D.   +4 more
core   +1 more source