Results 51 to 60 of about 1,217,623 (290)
Trained immunity modulators: A new frontier in immunoregulation and disease intervention
Journal of Advanced ResearchBackground: Immunotherapy has emerged as one of the most revolutionary approaches in disease treatments. However, most current and emerging immunotherapeutic strategies primarily target the adaptive immune system.
Jiao Chen +8 more
doaj +1 more source
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The plce of immunomodulators in the treatment of ENT organs
Медицинский совет, 2016 Acute and chronic diseases of the upper respiratory tract account for a significant proportion of diseases both in adults and children. For example, in the United States, sinusitis is now the most widespread disease the incidence of which is higher than ...
A. I. Kryukov +3 more
doaj +1 more source
Structurally similar allosteric modulators of α7 nicotinic acetylcholine receptors exhibit five distinct pharmacological effects. [PDF]
, 2015 Activation of nicotinic acetylcholine receptors (nAChRs) is associated with the binding of agonists such as acetylcholine to an extracellular site that is located at the interface between two adjacent receptor subunits.
Dhankher, P +4 more
core
FEBS Letters, EarlyView.Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani +3 more
wiley +1 more source
Secondary immune deficiency. Do we always need immunomodulators?
Медицинский совет, 2014 Respiratory infectious diseases represent one of the most common pathologies in outpatient care. Use of immunomodulators in multimodal treatment of infectious and inflammatory diseases has been widely discussed recently.
L. V. Luss, A. A. Martynov-radushinskiy
doaj +1 more source
An Overview of Artificial Immune Systems [PDF]
, 2004 The immune system is highly distributed, highly adaptive, self-organising in nature, maintains a memory of past encounters and has the ability to continually learn about new encounters.
E. Hart +7 more
core +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Prevention of infections by vaccines and immune modulators [PDF]
, 2017 Откриването и внедряването на ваксините и имуномодулаторите в медицинската практика е огромна крачка напред в предотвратяване на инфекциозните заболявания, някои от които са завършвали фатално при миналите векове.
Ivanova, Viktoria; Medical College `Y. Filaretova`, Medical University - Sofia +3 more
core +1 more source