Results 71 to 80 of about 1,217,623 (290)

Immune Priming: Mothering Males Modulate Immunity [PDF]

Current Biology, 2013
The transfer of immunity from mother to offspring is widespread in animals. The father's contribution to this is usually negligible. However, in a sex-role reversed pipefish where fathers do the mothering, fathers make an important immune priming contribution, too.
Keightley, M. Cristina, Wong, Bob B.M., Lieschke, Graham J.   +2 more
openaire   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Novel antiviral approaches for Marburg: a promising therapeutics in the pipeline

Frontiers in Microbiology
Marburg virus disease (MVD) presents a significant global health threat, lacking effective antivirals and with current supportive care offering limited therapeutic options.
Shriyansh Srivastava, Shriyansh Srivastava, Sachin Kumar, Sumel Ashique, Sathvik Belagodu Sridhar, Javedh Shareef, Sabin Thomas   +6 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Immune modulation and modulators in Heligmosomoides polygyrus infection [PDF]

Experimental Parasitology, 2012
The intestinal nematode parasite Heligmosomoides polygyrus bakeri exerts widespread immunomodulatory effects on both the innate and adaptive immune system of the host. Infected mice adopt an immunoregulated phenotype, with abated allergic and autoimmune reactions. At the cellular level, infection is accompanied by expanded regulatory T cell populations,
Maizels, Rick M., Hewitson, James P., Murray, Janice, Harcus, Yvonne M., Dayer, Blaise, Filbey, Kara J., Grainger, John R.; id_orcid 0000-0002-4052-5923, McSorley, Henry J., Reynolds, Lisa A., Smith, Katherine A.   +9 more
openaire   +2 more sources

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Schistosoma excretory/secretory products: an untapped library of tolerogenic immunotherapeutics against food allergy

Clinical & Translational Immunology
Food allergy (FA) is considered the ‘second wave’ of the allergy epidemic in developed countries after asthma and allergic rhinitis with a steadily growing burden of 40%.
Madeleine Rogers, Sandip Kamath, Donald McManus, Malcolm Jones, Catherine Gordon, Severine Navarro   +5 more
doaj   +1 more source

Modulation of Autophagy for Controlling Immunity [PDF]

Cells, 2019
Autophagy is an essential process that maintains physiological homeostasis by promoting the transfer of cytoplasmic constituents to autophagolysosomes for degradation. In immune cells, the autophagy pathway plays an additional role in facilitating proper immunological functions.
Young Jin Jang, Jae Hwan Kim, Sanguine Byun   +2 more
openaire   +3 more sources

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

SOME ASPECTS OF NON-SPECIFIC PROPHYLAXIS AND THERAPY OF ESPECIALLY DANGEROUS INFECTIONS

Журнал микробиологии, эпидемиологии и иммунобиологии, 2015
Recently, due to spread of dangerous and especially dangerous infections, much attention is given to development of complex approaches to their prophylaxis and therapy. Data on use of immune modulators, cytokines, probiotics, preparations of plant origin
A. V Filippenko, N. D Omelchenko, I. A Ivanova, I. A Bespalova, E. P Doroshenko, A. L Galicheva   +5 more
doaj