Results 81 to 90 of about 1,217,623 (290)
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Медицинский совет, 2015 The problem of inflammatory diseases of the throat in children with a history of allergy is becoming more urgent each year. The number of children living in large cities and having an allergic disease is steadily increasing.
N. L. Kunelskaya +5 more
doaj +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Trace minerals and the immune system: Impacts on the use of immune modulators and vaccine response
, 2018 The functions of trace mineral-dependent enzymes impact every aspect of the complex immune response. This includes, but is not limited to, the chemical components (interferon and interleukin), the innate cellular functionality (neutrophil and macrophage)
Havenga, Lourens J.
core +1 more source
Allosteric Modulators of Adenosine Receptors
, 2023 Allosterism occurs when a ligand binds to a receptor on a binding site distinct from the orthosteric one to which endogenous ligand normally binds. Among the G protein-coupled receptors (GPCRs), the adenosine receptors (ARs), classified as A1, A2A, A2B ...
Da Settimo, Federico +5 more
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Human Vaccines & Immunotherapeutics, 2018 Although the success of vaccination to date has been unprecedented, our inadequate understanding of the details of the human immune response to immunization has resulted in several recent vaccine failures and significant delays in the development of high-
Stacey L. Wooden, Wayne C. Koff
doaj +1 more source
Журнал микробиологии, эпидемиологии и иммунобиологии, 2017 Aim. Study immunologic phenotype of lymphocytes in the process of therapy of topic form of recombinant interferon-a2b during respiratory infections in pregnant. Materials aih. methods.
M. P. Kostinov +7 more
doaj +1 more source
Artificial Immune Recognition System (AIRS): AN Immune Inspired Supervised Machine Learning Algorithm [PDF]
, 2004 This paper presents the inception and subsequent revisions of an immune-inspired supervised learning algorithm, Artificial Immune Recognition System (AIRS).
Timmis, Jon +5 more
core +1 more source