Results 61 to 70 of about 1,217,623 (290)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
The therapeutic potential of sialylated Fc domains of human IgG
mAbs, 2021 Pathogens frequently use multivalent binding to sialic acid to infect cells or to modulate immunity through interactions with human sialic acid-binding immunoglobulin-type lectins (Siglecs).
Richard J. Pleass
doaj +1 more source
A Fractal Immune Network [PDF]
, 2004 Proteins are the driving force in development (embryogenesis) and the immune system. Here we describe how a model of proteins designed for evolutionary development in computers can be combined with a model of immune systems.
Peter J. Bentley +3 more
core +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
, 2010 High-performance micro-electro-mechanical systems (MEMS) sensors can be implemented by incorporating a micro-machined capacitive sensing element in a Sigma-Delta-Modulators force-feedback loop, forming an electro-mechanical Sigma-Delta Modulator (EM-SDM).
Kraft, Michael +2 more
core +1 more source
, 2021 International audienceSphingosine-1-phosphate modulators are approved for the treatment of multiple sclerosis and are under development for other immune-mediated conditions; however, safety concerns have arisen.PROSPERO ...
Olivera, Pablo +4 more
core +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Current Options in the Treatment of COVID-19: A Review
Risk Management and Healthcare Policy, 2020 Azadeh Teimury, Elahe Mahmoodi Khaledi Department of Cell and Molecular Biology, Faculty of Chemistry, University of Kashan, Kashan, IranCorrespondence: Elahe Mahmoodi KhalediDepartment of Cell and Molecular Biology, Faculty of Chemistry, University of ...
Teimury A, Mahmoodi Khaledi E
doaj
Bacteriophages as Pathogens and Immune Modulators?
mBio, 2013 While Shiga toxins (Stx) are key determinants of enterohemorrhagic Escherichia coli (EHEC) pathophysiology in humans, their dissemination to target organs following gastrointestinal EHEC infection is still poorly understood.
A. Lengeling, A. Mahajan, D. L. Gally
doaj +1 more source
Hormonal Modulation of Plant Immunity
Annual Review of Cell and Developmental Biology, 2012 Plant hormones have pivotal roles in the regulation of plant growth, development, and reproduction. Additionally, they emerged as cellular signal molecules with key functions in the regulation of immune responses to microbial pathogens, insect herbivores, and beneficial microbes.
Pieterse +8 more
openaire +6 more sources