Results 151 to 160 of about 119,167 (289)

Author Correction: Mechanically active integrins target lytic secretion at the immune synapse to facilitate cellular cytotoxicity. [PDF]

Nat Commun, 2023
Wang MS, Hu Y, Sanchez EE, Xie X, Roy NH, de Jesus M, Winer BY, Zale EA, Jin W, Sachar C, Lee JH, Hong Y, Kim M, Kam LC, Salaita K, Huse M.   +15 more
europepmc   +1 more source

CLinNET: An Interpretable and Uncertainty‐Aware Deep Learning Framework for Multi‐Modal Clinical Genomics

Advanced Science, EarlyView.
Identifying disease‐causing genes in neurocognitive disorders remains challenging due to variants of uncertain significance. CLinNET employs dual‐branch neural networks integrating Reactome pathways and Gene Ontology terms to provide pathway‐level interpretability of genomic alterations.
Ivan Bakhshayeshi, Mohammad Mahdi Hosseini, Ahmadreza Argha, Roxana Zahedi, Nigel H. Lovell, Hamid Alinejad‐Rokny   +5 more
wiley   +1 more source

Nanoscale CAR Organization at the Immune Synapse Correlates with CAR-T Effector Functions. [PDF]

Cells, 2023
Sajman J, Yakovian O, Unger Deshet N, Almog S, Horn G, Waks T, Globerson Levin A, Sherman E.   +7 more
europepmc   +1 more source

The cytotoxic T lymphocyte immune synapse at a glance [PDF]

, 2016
Nele M. G. Dieckmann, Gordon L. Frazer, Yukako Asano, Jane C. Stinchcombe, Gillian M. Griffiths   +4 more
openalex   +1 more source

Targeting the Notch1‐YY1‐ICAM1 Signaling Axis Enhances the Efficacy of Immunotherapy in HCC by Activating CD8+ T‐Cell‐Driven Cancer Cell Pyroptosis

Advanced Science, EarlyView.
In hepatocellular carcinoma (HCC), aberrantly activated Notch1 signaling induces its target gene YY1, which impairs immunotherapy efficacy by suppressing tumor cell‐ICAM1‐driven T cell activation and the mediated pyroptosis of T cells against tumor cells.
Ke Zhu, Fa‐Peng Zhang, Chao Qin, Zhi‐Xiao Song, Cai‐Ni Yang, Shu‐Sheng Lin, Xian‐Huan Yu, Wen‐Rui Wu, Chao‐Qun Liu, Chao Liu, Lei‐Bo Xu   +10 more
wiley   +1 more source

Ectocytosis renders T cell receptor signaling self-limiting at the immune synapse. [PDF]

Science, 2023
Stinchcombe JC, Asano Y, Kaufman CJG, Böhlig K, Peddie CJ, Collinson LM, Nadler A, Griffiths GM.   +7 more
europepmc   +1 more source

Analysis of Microtubules and Microtubule-Organizing Center at the Immune Synapse

, 2017
Noelia Blas‐Rus, Eugenio Bustos‐Morán, Francisco Sánchez‐Madrid, Noa B. Martín‐Cófreces   +3 more
openalex   +1 more source

Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses [PDF]

, 2009
Dongfang Liu, Yenan T. Bryceson, Tobias Meckel, Gaia Vasiliver-Shamis, Michael L. Dustin, Eric O. Long   +5 more
openalex   +1 more source

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

Vesicular traffic-mediated cell-to-cell signaling at the immune synapse in Ankylosing Spondylitis. [PDF]

Front Immunol, 2022
Tavasolian F, Pastrello C, Ahmed Z, Jurisica I, Inman RD.   +4 more
europepmc   +1 more source